Sulfamidosulfonamide derivatives and herbicides

ABSTRACT

A sulfamidosulfonamide derivative of the formula (1) and an agriculturally suitable salt thereof: ##STR1## wherein Q is ##STR2## X is an oxygen atom or a sulfur atom; and G is ##STR3## which are useful as herbicide.

TECHNICAL FIELD

The present invention relates to novel sulfamidosulfonamide derivatives and agriculturally suitable salts thereof, and herbicides containing them as active ingredients.

BACKGROUND TECHNIQUE

It is indispensable to use herbicides to protect important crop plants such as rice, wheat, corn, soybean, cotton and sugar beet from weeds and thereby to increase the harvest. Especially in recent years, a selective herbicide is desired which is capable of selectively killing weeds without showing any phytotoxicity against crop plants when applied to the foliages of crop plants and weeds simultaneously in a field where such useful crop plants and weeds are coexistent. Further, with a view to avoiding environmental pollution and reducing the costs for transportation and application, researches and developments have been conducted for many years for compounds having high herbicidal effects at low doses. Some of the compounds having such properties are presently used as selective herbicides. However, there still exists a need for better compounds having such properties.

As the prior art showing a chemical structure similar to that of the compounds of the present invention, Japanese Unexamined Patent Publication No. 45473/1990 discloses substituted sulfonyldiamides, and Japanese Unexamined Patent Publication No. 122671/1988 discloses 1-carbamoyl-2-pyrazolines. However, sulfamidosulfonamide derivatives having a pyrazoline structure like the compounds of the present invention have not been known at all, and they are novel compounds.

DISCLOSURE OF THE INVENTION

The present inventors have conducted extensive researches over years to develop selective herbicides for important crop plants and have studied herbicidal properties of many compounds with an aim to find out compounds having higher herbicidal activities as well as selectivity. As a result, it has been found that sulfamidosulfonamide derivatives of the following formula (1) and agriculturally suitable salts thereof (hereinafter referred to as the compounds of the present invention) exhibit remarkably strong herbicidal activities against many weeds in soil treatment or in foliage treatment and at the same time have a high level of safety for important crop plants such as wheat, corn, cotton, soybean, sugar beet and rice. The present invention has been accomplished on the basis of this discovery. On the other hand, since the compounds of the present invention show high herbicidal activities at a very low dose as compared with conventional herbicides, they are also useful as herbicides for orchards or for non-agricultural fields.

Namely, the present invention provides a sulfamidosulfonamide derivative of the formula (1) and an agriculturally suitable salt thereof: ##STR4## wherein Q is ##STR5## wherein R¹¹ is a hydrogen atom, a C₁₋₆ alkyl group, a C₃₋₇ cycloalkyl group, a C₁₋₆ alkyl group substituted by a C₃₋₇ cycloalkyl group, a C₂₋₆ alkenyl group, a C₁₋₆ alkynyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ mono- or poly-halogenoalkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylthio group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylsulfonyl group, a C₁₋₆ mono- or poly-halogenoalkyl group, a C₁₋₆ alkyl group substituted by a cyano group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylcarbonyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a nitro group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group and a C₁₋₆ alkoxycarbonyl group);

R¹² is a hydrogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group and a C₁₋₆ alkoxycarbonyl group);

R¹³ is a hydrogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₁₋₆ alkynyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group and a nitro group);

or, R¹² and R¹³ form, together with the nitrogen atom to which they are bonded, a saturated 5-7 membered heterocyclic group;

or, R¹² and R¹³ form, together with the oxygen atom and the nitrogen atom to which they are bonded, a saturated 5-7 membered heterocyclic group;

R²¹ is a hydrogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ mono- or poly-halogenoalkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylthio group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylsulfonyl group, a C₁₋₆ mono- or poly-halogenoalkyl group, a C₁₋₆ alkyl group substituted by a cyano group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylcarbonyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group and a nitro group);

R²² is a hydrogen atom or a C₁₋₆ alkyl group;

R²³ is a hydrogen atom or a C₁₋₆ alkyl group;

R²⁴ is a hydrogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a halogen atom, a C₁₋₆ mono- or poly-halogenoalkyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxy group, a C₁₋₆ alkyl group substituted by a C₂₋₆ alkenyloxy group, a C₁₋₆ alkyl group substituted by a C₂₋₆ alkynyloxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ mono- or poly-halogenoalkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylthio group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylsulfonyl group, a C₁₋₆ alkyl group substituted by a cyano group, a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkylcarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylcarbonyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group and a nitro group);

R²⁵ is a hydrogen atom or a C₁₋₆ alkyl group;

R²⁶ is a hydrogen atom or a C₁₋₆ alkyl group;

R²⁷ is a hydrogen atom or a C₁₋₆ alkyl group;

R²⁸ is a hydrogen atom, a halogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₆ mono- or poly-halogenoalkyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxy group, a C₁₋₆ alkyl group substituted by a C₂₋₆ alkenyloxy group, a C₁₋₆ alkyl group substituted by a C₂₋₆ alkynyloxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylthio group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylsulfonyl group, a C₁₋₆ alkyl group substituted by a cyano group, a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkylcarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylcarbonyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group and a nitro group);

X is an oxygen atom or a sulfur atom;

G is ##STR6## wherein each of a, b, c and d, which are independent from one another, is a hydrogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₆ alkyl group mono- or poly-substituted by a halogen atom, a C₁₋₆ alkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylthio group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylsulfonyl group, a C₁₋₆ alkylthio group, a C₁₋₆ alkylcarbonyl group, a C₃₋₇ cycloalkyl group, a C₃₋₇ cycloalkenyl group, a cyano group, a nitro group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group and a nitro group , a 5- or 6-membered heterocyclic group (provided that such a heterocyclic group contains from 1 to 3 hetero atoms selected from the group consisting of nitrogen atoms, oxygen atoms and sulfur atoms in the ring, or contains a sulfonyl group, and such a heterocyclic group may be substituted by one or more substituents selected from the group consisting of a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a halogen atom, a trifluoromethyl group, a nitro group and a C₁₋₆ alkoxycarbonyl group), a naphthyl group, a benzene-condensed heterocyclic group (provided that such a benzene-condensed heterocyclic group contains 1 or 2 hetero atoms selected from the group consisting of nitrogen atoms, oxygen atoms and sulfur atoms, and such a benzene-condensed heterocyclic group may be substituted by one or more substituents selected from the group consisting of a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a halogen atom, a trifluoromethyl group, a nitro group and a C₁₋₆ alkoxycarbonyl group).

The present invention also provides a selective herbicide containing one or more compounds of the present invention as active ingredients.

Further, the present invention provides a herbicidal composition comprising a herbicidally effective amount of one or more compounds of the present invention and an agricultural adjuvant.

Now, the present invention will be described in detail with reference to the preferred embodiments.

The compounds of the formula (1) of the present invention can easily be prepared by any one of the following reaction schemes 1 to 5. ##STR7## In the above formulas, Q, G and X are as defined above.

Namely, the reaction of a sulfamidosulfonyliso(thio)cyanate derivative (2) with a pyrazoline derivative (3), is conducted by using the sulfamidosulfonyliso(thio)cyanate derivative (2) in an amount of from 0.5 to 3.0 mols per mol of the pyrazoline derivative (3). Preferably the amount is within a range of from 0.8 to 1.2 mols.

The reaction temperature can be selected optionally within a range of from -50° C. to 200° C. However, the temperature is preferably within a range of from -20° C. to 50° C.

This reaction usually proceeds readily to present the compound (1) of the present invention. If the reaction tends to hardly proceed, a suitable base, for example, an organic base such as triethylamine, triethylenediamine, pyridine or 1,8-diazabicyclo[5.4.0]-7-undecene (DBU), a metal alkoxide such as sodium methoxide or sodium ethoxide, a metal hydride such as sodium hydride, an alkyl metal such as n-butyl lithium, or an inorganic base such as potassium carbonate, potassium hydroxide or sodium hydroxide, may be added to facilitate the reaction. As the base, it is particularly preferred to employ an organic base or an inorganic base.

As a solvent suitable for this reaction, a solvent inert to this reaction, for example, an aromatic hydrocarbon such as benzene, toluene or xylene, a halogenated hydrocarbon such as dichloromethane, chloroform, carbon tetrachloride, an ether such as diethyl ether, isopropyl ether, dioxane or tetrahydrofuran, a nitrile such as acetonitrile or propionitrile, a hydrocarbon such as petroleum ether, petroleum benzin or n-hexane, a ketone such as acetone or methyl ethyl ketone, an ester such as ethyl acetate, or an amide such as dimethylformamide, dimethylacetamide or hexamethylphosphoric acid triamide, may be mentioned. These solvents may be used alone or in combination as a mixture.

After completion of the reaction, usual posttreatment is conducted to obtain the compound (1) of the present invention. The structure of the compound of the present invention was determined by e.g. IR, NMR or MASS. ##STR8## In the above formulas, Q, G and X are as defined above, and Y is a C₁₋₆ alkyl group, a phenyl group or a benzyl group (provided that such an alkyl group, a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a C₁₋₆ alkyl group, C₁₋₆ alkoxy group and a halogen atom).

Namely, the reaction of a sulfamidosulfonamide derivative (4) with chloro(thio)formic acid ester or thio)carbonic acid diester is conducted by using the chloro(thio)formic acid ester or the (thio)carbonic acid diester in an amount of from 0.5 to 3.0 mols per mol of the sulfamidosulfonamide derivative (4). The amount is preferably within a range of from 0.8 to 1.2 mols.

The reaction temperature can be selected optionally within a range of from -50° C. to 200° C. However, it is preferably within a range of from -20° C. to 100° C.

This reaction is conducted by using various bases. The base is used in an amount of from 0.5 to 5.0 mols per mol of the sulfamidosulfonamide derivative (4). As a suitable base, an organic base such as triethylamine, triethylenediamine, pyridine, 1,8-diazabicyclo[5.4.0]-7-undecene (DBU), a metal alkoxide such as sodium methoxide or sodium ethoxide, a metal hydride such as sodium hydride, an alkyl metal such as n-butyl lithium, or an inorganic base such as potassium carbonate, potassium hydroxide or sodium hydroxide, may, for example, be used. It is particularly preferred to employ an organic base or an inorganic base.

As a solvent suitable for this reaction, a solvent inert to this reaction, for example, an aromatic hydrocarbon such as benzene, toluene or xylene, a halogenated hydrocarbon such as dichloromethane, chloroform or carbon tetrachloride, an ether such as diethyl ether, isopropyl ether, dioxane or tetrahydrofuran, a nitrile such as acetonitrile or propionitrile, a hydrocarbon such as petroleum ether, petroleum benzin or n-hexane, a ketone such as acetone or methyl ethyl ketone, an ester such as ethyl acetate, or an amide such as dimethylformamide, dimethylacetamide or hexamethylphosphoric acid triamide, may be mentioned. These solvents may be used alone or in combination as a mixture.

After completion of the reaction, usual posttreatment is conducted to obtain an N-sulfamidosulfonyl(thio)carbamate derivative (5).

Then, the reaction of the N-sulfamidosulfonyl(thio)carbamate derivative (5) with a pyrazoline derivative (3) is conducted by using the pyrazoline derivative (3) in an amount of from 0.5 to 10.0 mols per mol of the N-sulfamidosulfonyl(thio)carbamate derivative (5). The amount is preferably within a range of from 0.5 to 3.0 mols.

The reaction temperature can be selected optionally within a range of from 0° C. to 250° C. However, it is preferably within a range of from 50° C. to 150° C.

This reaction usually proceeds readily to present the compound (1) of the present invention. However, if the reaction tends to hardly proceed, a suitable base, for example, an organic base such as triethylamine, triethylenediamine, pyridine or 1,8-diazabicyclo[5.4.0]-7-undecene (DBU), a metal alkoxide such as sodium methoxide or sodium ethoxide, a metal hydride such as sodium hydride, an alkyl metal such as n-butyl lithium, or an inorganic base such as potassium carbonate, potassium hydroxide or sodium hydroxide, may be added to facilitate the reaction. As the base, it is particularly preferred to employ an organic base or an inorganic base.

As a solvent suitable for this reaction, a solvent inert to this reaction, for example, an aromatic hydrocarbon such as benzene, toluene or xylene, a halogenated hydrocarbon such as dichloromethane, chloroform or carbon tetrachloride, an ether such as diethyl ether, isopropyl ether, dioxane or tetrahydrofuran, a nitrile such as acetonitrile or propionitrile, a hydrocarbon such as petroleum ether, petroleum benzin or n-hexane, a ketone such as acetone or methyl ethyl ketone, an ester such as ethyl acetate, or an amide such as dimethylformamide, dimethylacetamide or hexamethylphosphoric acid triamide, may be mentioned. These solvents may be used alone or in combination as a mixture.

After completion of the reaction, usual posttreatment is conducted to obtain the compound (1) of the present invention. The structure of the compound of the present invention was determined by e.g. IR, NMR or MASS. ##STR9## In the above formulas, Q, G and Y are as defined above.

Namely, the reaction of a sulfamide (7) with an N-chlorosulfonylcarbamate derivative (6) is conducted by using the N-chlorosulfonylcarbamate derivative (6) in an amount of from 0.5 to 3.0 mols per mol of the sulfamide (7) The amount is preferably within a range of from 0.9 to 1.2 mols.

The reaction temperature may be selected optionally within a range of from -50° C. to 100° C. However, it is preferably within a range of from -20° C. to 30° C.

This reaction can be conducted by using various bases. The base is used in an amount of from 0.5 to 4.0 mols per mol of the sulfamide (7). As a suitable base, a metal hydride such as sodium hydride, a metal alkoxide such as sodium methoxide or sodium ethoxide, an alkyl metal such as n-butyl lithium, an organic base such as triethylamine, triethylenediamine, pyridine or 1,8-diazabicyclo[5.4.0]-7-undecene (DBU), or an inorganic base such as potassium carbonate, potassium hydroxide or sodium hydroxide, may be employed. It is particularly preferred to employ a metal hydride, an organic base or an inorganic base.

As a solvent suitable for this reaction, a solvent inert to this reaction, for example, an aromatic hydrocarbon such as benzene, toluene or xylene, a halogenated hydrocarbon such as dichloromethane, chloroform or carbon tetrachloride, an ether such as diethyl ether, isopropyl ether, dioxane or tetrahydrofuran, a nitrile such as acetonitrile or propionitrile, a hydrocarbon such as petroleum ether, petroleum benzin or n-hexane, a ketone such as acetone or methyl ethyl ketone, an ester such as ethyl acetate, or an amide such as dimethylformamide, dimethylacetamide or hexamethylphosphoric acid triamide, may be mentioned. These solvents may be used alone or in combination as a mixture. It is particularly preferred to employ an ether or an amide.

After completion of the reaction, usual posttreatment is conducted to obtain an N-sulfamidosulfonylcarbamate derivative (5; X=0).

Then, the reaction of the N-sulfamidosulfonylcarbamate derivative (5; X=0) with a pyrazoline derivative (3) is conducted by using the pyrazoline derivative (3) in an amount of from 0.5 to 10.0 mols per mol of the N-sulfamidosulfonylcarbamate derivative (5; X=0). The amount is preferably within a range of from 0.5 to 3.0 mols.

The reaction temperature can be selected optionally within a range of from 0° C. to 250° C. However, it is preferably within a range of from 50° C. to 150° C.

This reaction usually proceeds readily to present the compound (1) of the present invention. However, if the reaction tends to hardly proceed, a suitable base, for example, an organic base such as triethylamine, triethylenediamine, pyridine or 1,8-diazabicyclo[5.4.0]-7-undecene (DBU), a metal alkoxide such as sodium methoxide or sodium ethoxide, metal hydride such as sodium hydride, an alkyl metal such as n-butyl lithium, or an inorganic base such as potassium carbonate, potassium hydroxide or sodium hydroxide, may be added to facilitate the reaction. As the base, it is particularly preferred to employ an organic base or an inorganic base.

As a solvent suitable for this reaction, a solvent inert to this reaction, for example, an aromatic hydrocarbon such as benzene, toluene or xylene, a halogenated hydrocarbon such as dichloromethane, chloroform or carbon tetrachloride, an ether such as diethyl ether, isopropyl ether, dioxane or tetrahydrofuran, a nitrile such as acetonitrile or propionitrile, a hydrocarbon such as petroleum ether, petroleum benzin or n-hexane, a ketone such as acetone or methyl ethyl ketone, an ester such as ethyl acetate, or an amide such as dimethylformamide, dimethylacetamide or hexamethylphosphoric acid triamide, may be mentioned. These solvents may be used alone or in combination as a mixture.

After completion of the reaction, usual posttreatment is conducted to obtain the compound (1; X=0) of the present invention. The structure of the compound of the present invention was determined by e.g. IR, NMR or MASS. ##STR10## In the above formulas, Q, G and Y are as defined above.

Namely, the reaction of a sulfamidosulfonamide derivative (4) with a pyrazolinylformic acid ester (8) is conducted by using the pyrazolinylformic acid ester (8) in an amount of from 0.5 to 3.0 mols per mol of the sulfamidosulfonamide derivative (4). The amount is preferably within a range of from 0.8 to 1.2 mols.

The reaction temperature can be selected optionally within a range of from -50° C. to 100° C.

This reaction can be conducted by using various bases. The base is used in an amount of from 0.5 to 4.0 mols per mol of the sulfamidosulfonamide derivative (4). As a suitable base, an organic base such as triethylamine, triethylenediamine, pyridine or 1,8-diazabicyclo[5.4.0]-7-undecene (DBU), an inorganic base such as potassium carbonate, potassium hydroxide or sodium hydroxide, an alkyl metal such as n-butyl lithium or trimethyl aluminum, a metal hydride such as sodium hydride, or a metal alkoxide such as sodium methoxide or sodium ethoxide, may be employed. It is particularly preferred to employ an organic base, an inorganic base or an alkyl metal.

As a solvent suitable for this reaction, a solvent inert to this reaction, for example, an aromatic hydrocarbon such as benzene, toluene or xylene, a halogenated hydrocarbon such as dichloromethane, chloroform or carbon tetrachloride, an ether such as diethyl ether, isopropyl ether, dioxane or tetrahydrofuran, a nitrile such as acetonitrile or propionitrile, a hydrocarbon such as petroleum ether, petroleum benzin or n-hexane, a ketone such as acetone or methyl ethyl ketone, an ester such as ethyl acetate, or an amide such as dimethylformamide, dimethylacetamide or hexamethylphosphoric acid triamide, may be mentioned. These solvents may be used alone or in combination as a mixture.

After completion of the reaction, usual posttreatment is conducted to obtain the compound (1; X=0) of the present invention. The structure of the compound of the present invention was determined by e.g. IR, NMR or MASS. ##STR11## In the above formulas, Q and G are as defined above.

Namely, the reaction of a pyrazoline derivative (3) with a chlorosulfonyl isocyanate is conducted by using the chlorosulfonyl isocyanate in an amount of from 0.5 to 3.0 mols per mol of the pyrazoline derivative (3). The amount is preferably within a range of from 0.8 to 1.2 mols.

The reaction temperature can be selected optionally within a range of from -50° C. to 100° C. However, it is preferably within a range of from -30° C. to 50° C.

As a solvent suitable for this reaction, a solvent inert to this reaction, for example, an aromatic hydrocarbon such as benzene, toluene or xylene, a halogenated hydrocarbon such as dichloromethane, chloroform or carbon tetrachloride, an ether such as diethyl ether, isopropyl ether, dioxane or tetrahydrofuran, a nitrile such as acetonitrile or propionitrile, a hydrocarbon such as petroleum ether, petroleum benzin or n-hexane, a ketone such as acetone or methyl ethyl ketone, an ester such as ethyl acetate, or an amide such as dimethylformamide, dimethylacetamide or hexamethylphosphoric acid triamide, may be mentioned. These solvents may be used alone or in combination as a mixture.

This reaction usually proceeds readily without using a base.

Then, a suitable base is added to the reaction system of the pyrazoline derivative (3) and the chlorosulfonyl isocyanate, and a sulfamide derivative (7) is reacted to obtain a compound of the present invention (1; X=0). The base is used in an amount of from 0.5 to 4.0 mols, preferably from 0.8 to 2.2 mols, per mol of the pyrazoline derivative (3). Further, the sulfamide derivative (7) is used in an amount of from 0.5 to 2.0 mols, preferably from 0.8 to 1.2 mols, per mol of the pyrazoline derivative (3).

As a suitable base, an organic base such as triethylamine, triethylenediamine, pyridine or 1,8-diazabicyclo[5.4.0]-7-undecene (DBU), an inorganic base such as potassium carbonate, potassium hydroxide or sodium hydroxide, an alkyl metal such as n-butyl lithium, a metal hydride such as sodium hydride, or a metal alkoxide such as sodium methoxide or sodium ethoxide, may be employed. It is particularly preferred to employ an organic base, an inorganic base or a metal hydride.

The reaction temperature can be selected optionally within a range of from -50° C. to 150° C. However, it is preferably within a range of from -30° C. to 60° C.

After completion of the reaction, usual posttreatment is conducted to obtain the compound (1; X=0) of the present invention. The structure of the compound of the present invention was determined by e.g. IR, NMR or MASS.

The sulfamidosulfonyliso(thio)cyanate derivative (2) to be used in the Reaction scheme 1, can be prepared from the sulfamide derivative (7) or the sulfamidosulfonamide derivative (4) in accordance with the method disclosed in e.g. Japanese Unexamined Patent Publications No. 45473/1990, No. 151577/1989, No. 31775/1984, No. 148879/1983, No. 13266/1980 and No. 81320/1974.

Further, the sulfamidosulfonamide derivative (4) can be prepared from the sulfamide derivative (7) in accordance with the following Reaction schemes 6 and 7. ##STR12## In the above formulas, Q is as defined above.

In the Reaction scheme 6, removal of the tert-butyl group is conducted by using trifluoroacetic acid.

The amount of trifluoroacetic acid can be selected optionally from an equimolar amount to excess amount. Further, trifluoroacetic acid may be used as a solvent without any problem.

The reaction temperature can be selected optionally within a range of from -50° C. to 80° C. It is preferably within a range of from -20° C. to 30° C.

In a case where a solvent is employed in this reaction, a solvent inert to the reaction, for example, an aromatic hydrocarbon such as benzene, toluene or xylene, a halogenated hydrocarbon such as dichloromethane, chloroform or carbon tetrachloride, an ether such as diethyl ether, isopropyl ether, dioxane or tetrahydrofuran, a nitrile such as acetonitrile or propionitrile, a hydrocarbon such as petroleum ether, petroleum benzin or n-hexane, a ketone such as acetone or methyl ethyl ketone, an ester such as ethyl acetate, or an amide such as dimethylformamide, dimethylacetamide or hexamethylphosphoric acid triamide, may be used. These solvents may be used alone or in combination as a mixture. ##STR13## In the above formulas, Q is as defined above.

In the Reaction scheme 7, the reaction of t-butanol with chlorosulfonyl isocyanate can be conducted by a method per se known, such as the one disclosed in Japanese Unexamined Patent Publication No. 101323/1975.

The reaction of sulfamide (7) with tert-butyl sulfamoyl chloride is conducted by using tert-butyl sulfamoyl chloride in an amount of from 0.5 to 3.0 mols per mol of the sulfamide (7).

The reaction temperature can be selected optionally within a range of from -50° C. to 100° C. However, it is preferably within a range of from -20° C. to 30° C.

This reaction can be conducted by using various bases. The base is used in an amount of from 0.5 to 4.0 mols per mol of the sulfamide (7). The amount is preferably within a range of from 0.8 to 2.2 mols. As a suitable base, a metal hydride such as sodium hydride, a metal alkoxide such as sodium ethoxide, an alkyl metal such as n-butyl lithium, an organic base such as triethylamine, pyridine or 1,8-diazabicyclo[5.4.0]-7-undecene, or an inorganic base such as potassium hydroxide, sodium hydroxide or potassium carbonate, may be employed.

As a solvent suitable for this reaction, a solvent inert to this reaction, for example, an aromatic hydrocarbon such as benzene, toluene or xylene, a halogenated hydrocarbon such as dichloromethane, chloroform or carbon tetrachloride, an ether such as diethyl ether, isopropyl ether, dioxane or tetrahydrofuran, a nitrile such as acetonitrile or propionitrile, a hydrocarbon such as petroleum ether, petroleum benzin or n-hexane, a ketone such as acetone or methyl ethyl ketone, an ester such as ethyl acetate, or an amide such as dimethylformamide, dimethylacetamide or hexamethylphosphoric acid triamide, may be mentioned. These solvents may be used alone or in combination as a mixture. It is particularly preferred to employ an ether or an amide.

In the Reaction scheme 3, the N-chlorosulfonylcarbamate derivative (6) can be prepared by a method per se known in accordance with e.g. Chemishe Berichte, vol. 96, p. 56 (1963).

The sulfamide (7) to be used as the starting material for the above reactions, can readily be prepared in accordance with e.g. Synthetic organic Chemistry, Japan, vol. 27 (No. 10), p. 980 (1969); U.S. Pat. No. 2,624,729; Chemishe Berichte, vol. 111, p. 1915 (1978); Japanese Unexamined Patent Publications No. 208289/1983, No. 79894/1978; Indian Journal of Chemistry, Section B, vol. 21B, p. 941 (1982); Journal of the American Chemical Society, vol. 66, p. 1242 (1944); U.S. Pat. No. 2,826,594.

As typical examples, syntheses of 2,4-dimethyl-1,2,5-thiadiazolidine-1,1-dioxide, 2-methoxy-1,2,5-thiadiazolidine-1,1-dioxide, N,N-dimethyl-N'-ethylsulfamide, N,N-dimethyl-N'-methoxysulfamide and N-methyl-N-methoxy-N'-ethylsulfamide, will be described by Reaction schemes 8 to 12: ##STR14##

The pyrazoline derivative (3) to be used as a starting material in the above reactions can readily be prepared in accordance with e.g. Japanese Unexamined Patent Publication No. 122671/1988; U.S. Pat. No. 3,322,831; Journal of the American Chemical Society, vol. 80, p. 1926 (1958); Chemishe Berichte, vol. 35, p. 968 (1902); Shin Jikken Kagaku Koza, vol. 14, p. 1423. Typical Examples will be described by Reaction Schemes 13 to 21: ##STR15##

Now, preparation of the compounds of the present invention will be described in further detail with reference to Reference Examples and Examples. However, it should be understood that the present invention is by no means restricted by such specific Examples.

REFERENCE EXAMPLE 1 Preparation of phenyl N-[(N-dimethylsulfamoyl-N-methyl amino)sulfonyl]carbamate ##STR16##

4.0 g (100 mmol) of 60% sodium hydride was washed with n-hexane and suspended in 100 ml of dry tetrahydrofuran (THF). Then, 6.9 g (50 mmol) of N,N,N'-trimethylsulfamide dissolved in 20 ml of dry THF was added thereto under cooling with ice, and the mixture was gradually heated and stirred at room temperature for 3 hours.

Then, 50 ml of a dry THF solution containing 13.0 g (55 mmol) of phenyl N-chlorosulfonylcarbamate was dropwise added thereto under cooling with ice, and the mixture was gradually heated to room temperature and then stirred at room temperature for 3 hours.

The reaction mixture was poured into 1000 ml of ice water containing 1.05 g of 35% hydrochloric acid and extracted with diethyl ether. The diethyl ether layer was washed sequentially with water and a saturated sodium chloride aqueous solution and then dried over anhydrous magnesium sulfate. Then, the solvent was distilled off under reduced pressure to obtain 16.0 g of phenyl N-[(N-dimethylsulfamoyl-N-methylamino)sulfonyl]carbamate as slightly yellow oil.

REFERENCE EXAMPLE 2 Preparation of phenyl N-[(N-dimethylsulfamoyl-N-methoxyamino)sulfonyl]carbamate ##STR17##

2.69 g (61.5 mmol) of 55% sodium hydride was washed with n-hexane and then suspended in 100 ml of dry THF. Then, 4.62 g (30 mmol) of N,N-dimethyl-N'-methoxysulfamide dissolved in 20 ml of THF was dropwise added thereto under cooling with ice. The mixture is heated to room temperature and then stirred at room temperature for one hour. Then, this reaction mixture was again cooled with ice, and 7.07 g (30 mmol) of phenyl N-chlorosulfonylcarbamate dissolved in 30 ml of dry THF was dropwise added thereto. The mixture was heated to room temperature and then stirred at room temperature for 30 minutes. The reaction mixture was poured into 500 ml of ice water containing 6.4 g of 35% hydrochloric acid and extracted three times with 80 ml of diethyl ether. The extract solution was washed three times with 100 ml of water and once with 100 ml of a saturated sodium chloride aqueous solution and then dried over anhydrous magnesium sulfate. Then, the solvent was distilled off under reduced pressure to obtain 10.1 g of phenyl N-[(N-dimethylsulfamoyl-N-methoxyamino)sulfonyl]carbamate as slightly yellow oil.

REFERENCE EXAMPLE 3 Preparation of phenyl N-[(N-(N-methyl-N-methoxyaminosulfonyl)-N-methylamino)sulfonyl]carbamate ##STR18##

A mixture comprising 7 g (63 mmol) of methylsulfamic acid, 13.2 g (63 mmol) of phosphorus pentachloride and 100 ml of dry benzene, was refluxed for one hour. The reaction mixture was left to cool, and the solvent was distilled off under reduced pressure to obtain 7.63 g of methylsulfamoyl chloride.

5.75 g (58.9 mmol) of N,O-dimethylhydroxylamine hydrochloride was suspended in 300 ml of dichloromethane, and 11.9 g (118 mmol) of triethylamine was added thereto. Then, the mixture was cooled with ice, and a dichloromethane solution of 7.63 g of methylsulfamoyl chloride was dropwise added, and the mixture was stirred at room temperature for 3 hours. The solvent was distilled off under reduced pressure. To the residue, 200 ml of benzene was added, and insoluble substance was filtered off. Then, the solvent was distilled off again under reduced pressure. By the distillation under reduced pressure, 4.4 g of N,N'-dimethyl-N'-methoxysulfamide was obtained (boiling point: 85°-88° C./1.9 mmHg).

1.15 g (28.8 mmol) of 60% sodium hydride was washed with n-hexane, and dry THF was added, and the mixture was cooled with ice. To this mixture, a THF solution containing 2 g (13 mmol) of N,N'-dimethyl-N'-methoxysulfamide was dropwise added. After stirring the mixture for 10 minutes, a dry THF solution containing 3.21 g (13.6 mmol) of phenyl N-chlorosulfonylcarbamate was dropwise added thereto. The mixture was stirred at room temperature for 7 hours. The reaction mixture was poured into 500 ml of ice water containing 3.5 g of 35% hydrochloric acid and extracted three times with diethyl ether. The diethyl ether layer was washed sequentially with water and a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 4.3 g of phenyl N-[(N-(N-methyl N-methoxyaminosulfonyl)-N-methylamino)sulfonyl]carbamate as slightly yellow oil.

REFERENCE EXAMPLE 4 Preparation of phenyl N-(2-methyl-tetrahydro-1,2,6-thiadiazine-1,1-dioxide-6-sulfonyl)carbamate ##STR19##

A mixture comprising 30 g (312 mmol) of sulfamide, 27.5 g (312 mmol) of N-methyl-1,3-propanediamine and 300 ml of dry pyridine was refluxed overnight at 130° C. The mixture was left to cool, and then pyridine was distilled off under reduced pressure. To the residue, 200 ml of chloroform was added and insoluble substance was filtered off. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (CHCl₃) and then subjected to distillation under reduced pressure to obtain 36.2 g of 2-methyl-tetrahydro-1,2,6-thiadiazine-1,1-dioxide (boiling point: 130°-133° C./0.23 mmHg).

Then, 5.87 g (147 mmol) of 60% sodium hydride was washed twice with 30 ml of n-hexane, and then 30 ml of dry THF was added thereto, and the mixture was cooled with ice. To this mixture, a dry THF solution containing 10.0 g (66.7 mmol) of 2-methyl-tetrahydro-1,2,6-thiadiazine-1,1-dioxide was dropwise added, and the mixture was stirred at room temperature for 2.5 hours. The solution was cooled again with ice, and a dry THF solution containing 16.5 g (70 mmol) of phenyl N-chlorosulfonylcarbamate, was dropwise added thereto. The mixture was stirred at room temperature for 2 hours, and then poured into 1500 ml of ice water containing 17.4 g of 35% hydrochloric acid and extracted twice with diethyl ether. The diethyl ether layer was washed twice with water and once with a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 20.0 g of the desired phenyl N-(2-methyltetrahydro-1,2,6-thiadiazine-1,1-dioxide-6-sulfonyl)carbamate. Melting point: 144°-145° C.

The structures and physical properties or characteristics of the compounds prepared in the same manner as in the above Reference Examples 1 to 4 are shown below:

    ______________________________________                                          ##STR20##                 Slightly yellow oil                                  ##STR21##                 Slightly yellow oil                                  ##STR22##                 Slightly yellow oil                                  ##STR23##                 Slightly yellow oil                                  ##STR24##                 m.p. 96-97° C.                                ##STR25##                 Slightly yellow oil                                  ##STR26##                 Slightly yellow oil                                  ##STR27##                 Slightly yellow oil                                  ##STR28##                 Slightly yellow oil                                  ##STR29##                 Slightly yellow oil                                  ##STR30##                 Slightly yellow oil                                  ##STR31##                 Slightly yellow oil                                  ##STR32##                 Slightly yellow oil                                  ##STR33##                 Slightly yellow oil                                  ##STR34##                 Slightly yellow oil                                  ##STR35##                 Slightly yellow oil                                  ##STR36##                 Slightly yellow oil                                  ##STR37##                 Slightly yellow oil                                  ##STR38##                 Slightly yellow oil                                  ##STR39##                 Slightly yellow oil                                  ##STR40##                 Slightly yellow oil                                  ##STR41##                 Slightly yellow oil                                  ##STR42##                 Slightly yellow oil                                  ##STR43##                 Slightly yellow oil                                  ##STR44##                 Slightly yellow oil                                  ##STR45##                 Slightly yellow oil                                  ##STR46##                 Slightly yellow oil                                  ##STR47##                 m.p. 137˜ 139° C.                       ##STR48##                 Slightly yellow oil                                  ##STR49##                 Slightly yellow oil                                  ##STR50##                 Slightly yellow oil                                  ##STR51##                 Slightly yellow oil                                  ##STR52##                 Slightly yellow oil                                  ##STR53##                 Slightly yellow oil                                  ##STR54##                 Slightly yellow oil                                  ##STR55##                 Slightly yellow oil                                  ##STR56##                 Slightly yellow oil                                  ##STR57##                 Slightly yellow oil                                  ##STR58##                 Slightly yellow oil                                  ##STR59##                 Slightly yellow oil                                  ##STR60##                 Slightly yellow oil                                  ##STR61##                 Slightly yellow oil                                  ##STR62##                 Slightly yellow oil                                  ##STR63##                 Slightly yellow oil                                  ##STR64##                 Slightly yellow oil                                  ##STR65##                 Slightly yellow oil                                  ##STR66##                 Slightly yellow oil                                  ##STR67##                 Slightly yellow oil                                  ##STR68##                 Slightly yellow oil                                  ##STR69##                 Slightly yellow oil                                  ##STR70##                 Slightly yellow oil                                  ##STR71##                 Slightly yellow oil                                  ##STR72##                 Slightly yellow oil                                  ##STR73##                 Slightly yellow oil                                  ##STR74##                 Slightly yellow oil                                  ##STR75##                 Slightly yellow oil                                  ##STR76##                 Slightly yellow oil                                  ##STR77##                 Slightly yellow oil                                  ##STR78##                 Slightly yellow oil                                  ##STR79##                 m.p. 139˜ 140° C.                       ##STR80##                 Slightly yellow oil                                  ##STR81##                 Slightly yellow oil                                  ##STR82##                 m.p. 144˜ 145° C.                       ##STR83##                 m.p. 142˜ 143° C.                       ##STR84##                 Slightly yellow oil                                  ##STR85##                 Slightly yellow oil                                  ##STR86##                 m.p. 160˜ 161° C.                       ##STR87##                 Slightly yellow oil                                 ______________________________________                                          m.p.: melting point                                                      

REFERENCE EXAMPLE 5 Preparation of 3-methyl-5-phenyl-2-pyrazoline ##STR88##

17.1 g (342 mmol) of hydrazine monohydrate was dissolved in 500 ml of methanol. Then, 50 g (342 mmol) of trans-4-phenyl-3-buten-2-one dissolved in 100 ml of methanol was gradually dropwise added thereto under stirring within a range of from 5° C. to 15° C. Then, the mixture was stirred at room temperature for 30 hours, and methanol was distilled off under reduced pressure. The residue was distilled under reduced pressure to obtain 41.0 g of the desired 3-methyl-5-phenyl-2-pyrazoline.

Boiling point: 113°-115° C./0.2 mmHg.

The structural formulas and the physical properties or characteristics of the pyrazoline derivatives (3) prepared in the same manner as in Reference Example 5 are shown below:

    ______________________________________                                          ##STR89##                                                                      ##STR90##                                                                      ##STR91##                                                                      ##STR92##                                                                      ##STR93##                                                                      ##STR94##                                                                      ##STR95##                                                                      ##STR96##                                                                      ##STR97##                                                                      ##STR98##                                                                      ##STR99##                                                                      ##STR100##                                                                     ##STR101##                                                                     ##STR102##                                                                     ##STR103##                                                                     ##STR104##                                                                     ##STR105##                                                                     ##STR106##                                                                     ##STR107##                                                                     ##STR108##                                                                     ##STR109##                                                                     ##STR110##                                                                     ##STR111##                                                                     ##STR112##                                                                     ##STR113##                                                                     ##STR114##                                                                     ##STR115##                                                                     ##STR116##                                                                     ##STR117##                                                                     ##STR118##                                                                     ##STR119##                                                                     ##STR120##                                                                     ##STR121##                                                                     ##STR122##                                                                     ##STR123##                                                                     ##STR124##                                                                     ##STR125##                                                                     ##STR126##                                                                     ##STR127##                                                                     ##STR128##                                                                     ##STR129##                                                                     ##STR130##                                                                     ##STR131##                                                                     ##STR132##                                                                     ##STR133##                                                                     ##STR134##                                                                     ##STR135##                                                                     ##STR136##                                                                    ______________________________________                                          b.p.: boiling point                                                      

EXAMPLE 1 Preparation of 1-[(N-dimethylsulfamoyl-N-ethylamino)sulfonylcarbamoyl]-3-methyl-5-phenyl-2-pyrazoline ##STR137##

A mixture comprising 3.3 g (9.4 mmol) of phenyl N-(N-dimethylsulfamoyl-N-ethylamino)sulfonyl]carbamate, 3.76 g (23.5 mmol) of 3-methyl-5-phenyl-2-pyrazoline and 30 ml of dry benzene was refluxed for 5 minutes. The mixture was left to cool, and then 50 ml of benzene was added thereto. The benzene layer was washed twice with dilute hydrochloric acid and then twice with water. Then, it was dried over anhydrous sodium sulfate. Thereafter, the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (CHCl₃) and then washed sequentially with n-hexane and diethyl ether to obtain 2 g of the desired 1-[(N-dimethylsulfamoyl-N-ethylamino)sulfonylcarbamoyl]-3-methyl-5-phenyl-2-pyrazoline.

Melting point: 138°-139° C.

EXAMPLE 2 Preparation of 1-[(N-dimethylsulfamoyl-N-methylamino)sulfonylcarbamoyl]-3-methyl-5-(2-thienyl)-2-pyrazoline ##STR138##

A mixture comprising 1.69 g (5.0 mmol) of phenyl N-[(N-dimethylsulfamoyl-N-methylamino)sulfonyl]carbamate, 0.58 g (3.5 mmol) of 3-methyl-5-(2-thienyl)-2-pyrazoline and 10 ml of dry benzene, was refluxed for 10 minutes. The mixture was left to cool, and then benzene was distilled off under reduced pressure. The obtained residue was washed with n-hexane. Then, the residue was stirred together with diethyl ether. The precipitated crystalline product was isolated by suction filtration and then washed with diethyl ether to obtain 1.1 g of the desired 1-[(N-dimethylsulfamoyl-N-methylamino)sulfonylcarbamoyl]-3-methyl-5-(2-thienyl)-2-pyrazoline.

Melting point: 112°-113° C.

EXAMPLE 3 Preparation of 1-[(N-dimethylsulfamoyl-N-methoxyamino)sulfonylcarbamoyl]-3-methyl-5-phenyl-2-pyrazoline ##STR139##

4.24 g (12 mmol) of phenyl N-[(N-dimethylsulfamoyl-N-methoxyamino)sulfonyl]carbamate was dissolved in 30 ml of dry benzene, and 1.6 g (10 mmol) of 3-methyl-5-phenyl-2-pyrazoline was added thereto. The mixture was refluxed for 5 minutes. The mixture was left to cool, and the solvent was distilled off under reduced pressure. The residue was purified by reverse phase column chromatography (CH₃ CN: H₂ O=7:3) to obtain 1.0 g of the desired 1-[(N-dimethylsulfamoyl-N-methoxyamino)sulfonylcarbamoyl]-3-methyl-5-phenyl-2-pyrazoline.

Melting point: 104°-105° C.

EXAMPLE 4 Preparation of 1-[(N-(N-methyl-N-methoxyaminosulfonyl)-N-methylamino)sulfonylcarbamoyl]-3-methyl-5-phenyl-2-pyrazoline ##STR140##

A mixture comprising 1 g (2.83 mmol) of phenyl N-[(N-(N-methyl-N-methoxyaminosulfonyl)-N-methylamino)sulfonyl]-carbamate, 0.45 g (2.81 mmol) of 3-methyl-5-phenyl-2-pyrazoline and 30 ml of dry benzene was heated at 80° C. for 5 minutes. The mixture was left to cool, and then the solvent was distilled off under reduced pressure. The residue was purified by reverse phase column chromatography (CH₃ CN: H₂ O=7:3) to obtain 0.5 g of the desired 1-[(N-(N-methyl-N-methoxyaminosulfonyl)-N-methyl-amino)sulfonylcarbamoyl]-3-methyl-5-phenyl-2-pyrazoline as glassy substance.

EXAMPLE 5 Preparation of 1-(2-methyl-tetrahydro-1,2,6-thiadiazine-1,1-dioxide-6-sulfonylcarbamoyl)-3-methyl-5-phenyl-2-pyrazoline ##STR141##

A mixture comprising 0.70 g (2 mmol) of phenyl N-(2-methyl-tetrahydro-1,2,6-thiadiazine-1,1-dioxide-6-sulfonyl)carbamate, 0.80 g (5 mmol) of 3-methyl-5-phenyl-2-pyrazoline and 30 ml of dry benzene, was refluxed for 5 minutes. The mixture was left to cool, and then 50 ml of benzene was added thereto. The benzene layer was washed three times with dilute hydrochloric acid and twice with water. Then, it was dried over anhydrous sodium sulfate, and then solvent was distilled off under reduced pressure. The obtained residue was washed sequentially with n-hexane and diethyl ether to obtain 0.7 g of the desired 1-(2-methyl-tetrahydro-1,2,6-thiadiazine-1,1- dioxide-6-sulfonylcarbamoyl)-3-methyl-5-phenyl-2-pyrazoline.

Melting point: 147°-148° C.

EXAMPLE 6 Preparation of 1-(2-methyl-tetrahydro-1,2,6-thiadiazine- 1,1-dioxide-6-sulfonylcarbamoyl)-3,5-dimethyl-5-phenyl-2-pyrazoline ##STR142##

A mixture comprising 8 g (22.9 mmol) of phenyl N-(2-methyl-tetrahydro-1,2,6-thiadiazine-1,1-dioxide-6-sulfonyl)carbamate, 5.1 g (29.3 mmol) of 3,5-dimethyl-5-phenyl-2-pyrazoline and 200 ml of dry benzene, was heated at 80° C. for 5 minutes. The mixture was left to cool, and then solvent was distilled off under reduced pressure. The residue was washed with diethyl ether to obtain 6.2 g of the desired 1-(2-methyl-tetrahydro-1,2,6-thiadiazine-1,1-dioxide-6-sulfonylcarbamoyl)-3,5-dimethyl-5-phenyl-2-pyrazoline.

Melting point: 151°-154° C.

The structural formulas and the physical properties or characteristics of the compounds prepared in the same manner as in Examples 1 to 6 are shown below: ##STR143##

Examples of compounds covered by the present invention including those prepared in the preceding Examples will be given in the following Tables 1 to 14 and Tables 1A to 14A. However, it should be understood that the compounds of the present invention are not limited to such specific Examples.

The symbols in the Tables have the following meanings.

Me: methyl group, Et: ethyl group, Pr-n: n-propyl group, Pr-i: isopropyl group, cyc-Pr: cyclopropyl group, Bu-n: n-butyl group, Bu-i: isobutyl group, Bu-sec: secondary butyl group, Bu-t: tert-butyl group, cyc-Bu: cyclobutyl group, Pen-n: n-pentyl group, cyc-Hex: cyclohexyl group, Ph: phenyl group, Gn is the same as the above G, and Ga, Gb and Gc have the following meanings.

Ga=G1-G643 (i.e. it means any one of G1 to G643.)

Gb=G1 -G72 and G102-G136 (i.e. it means any one of G1 to G72 and G102 to G136 .)

Gc=G1 -G35 and G102 -G136 (i.e. it means any one of G1 to G35 and G102 to G136 .) ##STR144##

                  TABLE 1                                                          ______________________________________                                         R.sup.11    R.sup.12     R.sup.13    Gn                                        ______________________________________                                         H           Me           Me          Ga                                        H           Me           Et          Ga                                        H           Me           Ph          Ga                                        H           Me           PhCH.sub.2  Ga                                        H           Et           Et          Ga                                        H           Pr-n         Pr-n        Gb                                        H           (CH.sub.2).sub.4     Ga                                            H           (CH.sub.2).sub.5     Ga                                            Me          H            Me          Gc                                        Me          H            Et          Gc                                        Me          Me           Me          Ga                                        Me          Me           Et          Ga                                        Me          Me           Pr-n        Gb                                        Me          Me           Pr-i        Gb                                        Me          Me           Bu-n        Gb                                        Me          Me           Ph          Ga                                        Me          Me           Ph-2-Cl     Gb                                        Me          Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        Me          Me           Ph-2-OMe    Gb                                        Me          Me           Ph-2-CF.sub.3                                                                              Gb                                        Me          Me           Ph-2-NO.sub.2                                                                              Gb                                        Me          Me           Ph-2-Me     Gb                                        Me          Me           PhCH.sub.2  Ga                                        Me          Et           Et          Ga                                        Me          Pr-n         Pr-n        Gb                                        Me          (CH.sub.2).sub.4     Ga                                            Me          (CH.sub.2).sub.5     Ga                                            Et          H            Me          Gc                                        Et          H            Et          Gc                                        Et          Me           Me          Ga                                        Et          Me           Et          Ga                                        Et          Me           Pr-n        Gb                                        Et          Me           Pr-i        Gb                                        Et          Me           Bu-n        Gb                                        Et          Me           Ph          Ga                                        Et          Me           Ph-2-Cl     Gb                                        Et          Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        Et          Me           Ph-2-OMe    Gb                                        Et          Me           Ph-2-CF.sub.3                                                                              Gb                                        Et          Me           Ph-2-NO.sub.2                                                                              Gb                                        Et          Me           Ph-2-Me     Gb                                        Et          Me           PhCH.sub.2  Ga                                        Et          Et           Et          Ga                                        Et          Pr-n         Pr-n        Gb                                        Et          (CH.sub.2).sub.4     Ga                                            Et          (CH.sub.2).sub.5     Ga                                            Pr-n        H            Me          Gc                                        Pr-n        H            Et          Gc                                        Pr-n        Me           Me          Ga                                        Pr-n        Me           Et          Ga                                        Pr-n        Me           Pr-n        Gb                                        Pr-n        Me           Pr-i        Gb                                        Pr-n        Me           Bu-n        Gb                                        Pr-n        Me           Ph          Ga                                        Pr-n        Me           Ph-2-Cl     Gb                                        Pr-n        Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        Pr-n        Me           Ph-2-OMe    Gb                                        Pr-n        Me           Ph-2-CF.sub.3                                                                              Gb                                        Pr-n        Me           Ph-2-NO.sub.2                                                                              Gb                                        Pr-n        Me           Ph-2-Me     Gb                                        Pr-n        Me           PhCH.sub.2  Ga                                        Pr-n        Et           Et          Ga                                        Pr-n        Pr-n         Pr-n        Gb                                        Pr-n        (CH.sub.2).sub.4     Ga                                            Pr-n        (CH.sub.2).sub.5     Ga                                            Pr-i        H            Me          Gc                                        Pr-i        H            Et          Gc                                        Pr-i        Me           Me          Ga                                        Pr-i        Me           Et          Ga                                        Pr-i        Me           Pr-n        Gb                                        Pr-i        Me           Pr-i        Gb                                        Pr-i        Me           Bu-n        Gb                                        Pr-i        Me           Ph          Ga                                        Pr-i        Me           Ph-2-Cl     Gb                                        Pr-i        Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        Pr-i        Me           Ph-2-OMe    Gb                                        Pr-i        Me           Ph-2-CF.sub.3                                                                              Gb                                        Pr-i        Me           Ph-2-NO.sub.2                                                                              Gb                                        Pr-i        Me           Ph-2-Me     Gb                                        Pr-i        Me           PhCH.sub.2  Ga                                        Pr-i        Et           Et          Ga                                        Pr-i        Pr-n         Pr-n        Gb                                        Pr-i        (CH.sub.2).sub.4     Ga                                            Pr-i        (CH.sub.2).sub.5     Ga                                            cyc-Pr      Me           Me          Ga                                        cyc-Pr      Me           Et          Ga                                        cyc-Pr      Me           Ph          Ga                                        cyc-Pr      Me           PhCH.sub.2  Ga                                        cyc-Pr      Et           Et          Ga                                        cyc-Pr      Pr-n         Pr-n        Gb                                        cyc-Pr      (CH.sub.2).sub.4     Ga                                            cyc-Pr      (CH.sub.2).sub.5     Ga                                            cyc-PrCH.sub.2                                                                             Me           Me          Ga                                        cyc-PrCH.sub.2                                                                             Me           Et          Ga                                        cyc-PrCH.sub.2                                                                             Me           Ph          Ga                                        cyc-PrCH.sub.2                                                                             Me           PhCH.sub.2  Ga                                        cyc-PrCH.sub.2                                                                             Et           Et          Ga                                        cyc-PrCH.sub.2                                                                             Pr-n         Pr-n        Gb                                        cyc-PrCH.sub.2                                                                             (CH.sub.2).sub.4     Ga                                            cyc-PrCH.sub.2                                                                             (CH.sub.2).sub.5     Ga                                            Bu-n        H            Me           Gc                                       Bu-n        H            Et          Gc                                        Bu-n        Me           Me          Ga                                        Bu-n        Me           Et          Ga                                        Bu-n        Me           Pr-n        Gb                                        Bu-n        Me           Pr-i        Gb                                        Bu-n        Me           Bu-n        Gb                                        Bu-n        Me           Ph          Ga                                        Bu-n        Me           Ph-2-Cl     Gb                                        Bu-n        Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        Bu-n        Me           Ph-2-OMe    Gb                                        Bu-n        Me           Ph-2-CF.sub.3                                                                              Gb                                        Bu-n        Me           Ph-2-NO.sub.2                                                                              Gb                                        Bu-n        Me           Ph-2-Me     Gb                                        Bu-n        Me           PhCH.sub.2  Ga                                        Bu-n        Et           Et          Ga                                        Bu-n        Pr-n         Pr-n        Gb                                        Bu-n        (CH.sub.2).sub.4     Ga                                            Bu-n        (CH.sub.2).sub.5     Ga                                            Bu-sec      H            Me          Gc                                        Bu-sec      H            Et          Gc                                        Bu-sec      Me           Me          Ga                                        Bu-sec      Me           Et          Ga                                        Bu-sec      Me           Ph          Ga                                        Bu-sec      Me           PhCH.sub.2  Ga                                        Bu-sec      Et           Et          Ga                                        Bu-sec      Pr-n         Pr-n        Gb                                        Bu-sec      (CH.sub.2).sub.4     Ga                                            Bu-sec      (CH.sub.2).sub.5     Ga                                            Bu-t        H            Me          Gc                                        Bu-t        H            Et          Gc                                        Bu-t        Me           Me          Ga                                        Bu-t        Me           Et          Ga                                        Bu-t        Me           Ph          Ga                                        Bu-t        Me           PhCH.sub.2  Ga                                        Bu-t        Et           Et          Ga                                        Bu-t        Pr-n         Pr-n        Gb                                        Bu-t        (CH.sub.2).sub.4     Ga                                            Bu-t        (CH.sub.2 ).sub.5    Ga                                            CH.sub.2CHCH.sub.2                                                                         H            Me          Gc                                        CH.sub.2CHCH.sub.2                                                                         H            Et          Gc                                        CH.sub.2CHCH.sub.2                                                                         Me           Me          Ga                                        CH.sub.2CHCH.sub.2                                                                         Me           Et          Ga                                        CH.sub.2CHCH.sub.2                                                                         Me           Pr-n        Gb                                        CH.sub.2CHCH.sub.2                                                                         Me           Pr-i        Gb                                        CH.sub.2CHCH.sub.2                                                                         Me           Bu-n        Gb                                        CH.sub.2CHCH.sub.2                                                                         Me           Ph          Ga                                        CH.sub.2CHCH.sub.2                                                                         Me           Ph-2-Cl     Gb                                        CH.sub.2CHCH.sub.2                                                                         Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        CH.sub.2CHCH.sub.2                                                                         Me           Ph-2-OMe    Gb                                        CH.sub.2CHCH.sub.2                                                                         Me           Ph-2-CF.sub.3                                                                              Gb                                        CH.sub.2CHCH.sub.2                                                                         Me           Ph-2-NO.sub.2                                                                              Gb                                        CH.sub.2CHCH.sub.2                                                                         Me           Ph-2-Me     Gb                                        CH.sub.2CHCH.sub.2                                                                         Me           PhCH.sub.2  Ga                                        CH.sub.2CHCH.sub.2                                                                         Et           Et          Ga                                        CH.sub.2CHCH.sub.2                                                                         Pr-n         Pr-n        Gb                                        CH.sub.2CHCH.sub.2                                                                         (CH.sub.2).sub.4     Ga                                            CH.sub.2CHCH.sub.2                                                                         (CH.sub.2).sub.5     Ga                                            CH CCH.sub.2                                                                               H            Me          Gc                                        CH CCH.sub.2                                                                               H            Et          Gc                                        CH  CCH.sub.2                                                                              Me           Me          Ga                                        CH CCH.sub.2                                                                               Me           Et          Ga                                        CH CCH.sub.2                                                                               Me           Pr-n        Gb                                        CH CCH.sub.2                                                                               Me           Pr-i        Gb                                        CH CCH.sub.2                                                                               Me           Bu-n        Gb                                        CH CCH.sub.2                                                                               Me           Ph          Ga                                        CH CCH.sub.2                                                                               Me           Ph-2-Cl     Gb                                        CH CCH.sub.2                                                                               Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        CH CCH.sub.2                                                                               Me           Ph-2-OMe    Gb                                        CH CCH.sub.2                                                                               Me           Ph-2-CF.sub.3                                                                              Gb                                        CH CCH.sub.2                                                                               Me           Ph-2-NO.sub.2                                                                              Gb                                        CH CCH.sub.2                                                                               Me           Ph-2-Me     Gb                                        CH CCH.sub.2                                                                               Me           PhCH.sub.2  Ga                                        CH  CCH.sub.2                                                                              Et           Et          Ga                                        CH CCH.sub.2                                                                               Pr-n         Pr-n        Gb                                        CH CCH.sub.2                                                                               (CH.sub.2).sub.4     Ga                                            CH CCH.sub.2                                                                               (CH.sub.2).sub.5     Ga                                            MeOCH.sub.2 Me           Me          Ga                                        MeOCH.sub.2 Me           Et          Ga                                        MeOCH.sub.2 Me           Ph          Ga                                        MeOCH.sub.2 Me           PhCH.sub.2  Ga                                        MeOCH.sub.2 Et           Et          Ga                                        MeOCH.sub.2 Pr-n         Pr-n        Gb                                        MeOCH.sub.2 (CH.sub.2).sub.4     Ga                                            MeOCH.sub.2 (CH.sub.2).sub.5     Ga                                            EtOCH.sub.2 Me           Me          Ga                                        EtOCH.sub.2 Me           Et          Ga                                        EtOCH.sub.2 Me           Ph          Ga                                        EtOCH.sub.2 Me           PhCH.sub.2  Ga                                        EtOCH.sub.2 Et           Et          Ga                                        EtOCH.sub.2 Pr-n         Pr-n        Gb                                        EtOCH.sub.2 (CH.sub.2).sub.4     Ga                                            EtOCH.sub.2 (CH.sub.2).sub.5     Ga                                            MeOCH.sub.2 CH.sub.2                                                                       H            Me          Gc                                        MeOCH.sub.2 CH.sub.2                                                                       H            Et          Gc                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Me          Ga                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Et          Ga                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Pr-n        Gb                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Pr-i        Gb                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Bu-n        Gb                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Ph          Ga                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-Cl     Gb                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-OMe    Gb                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-CF.sub.3                                                                              Gb                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-NO.sub.2                                                                              Gb                                        MeOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-Me     Gb                                        MeOCH.sub.2 CH.sub.2                                                                       Me           PhCH.sub.2  Ga                                        MeOCH.sub.2 CH.sub.2                                                                       Et           Et          Ga                                        MeOCH.sub.2 CH.sub.2                                                                       Pr-n         Pr-n        Gb                                        MeOCH.sub.2 CH.sub.2                                                                       (CH.sub.2).sub.4     Ga                                            MeOCH.sub.2 CH.sub.2                                                                       (CH.sub.2).sub.5     Ga                                            EtOCH.sub.2 CH.sub.2                                                                       H            Me          Gc                                        EtOCH.sub.2 CH.sub.2                                                                       H            Et          Gc                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Me          Ga                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Et          Ga                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Pr-n        Gb                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Pr-i        Gb                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Bu-n        Gb                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Ph          Ga                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-Cl     Gb                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-OMe    Gb                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-CF.sub.3                                                                              Gb                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-NO.sub.2                                                                              Gb                                        EtOCH.sub.2 CH.sub.2                                                                       Me           Ph-2-Me     Gb                                        EtOCH.sub.2 CH.sub.2                                                                       Me           PhCH.sub.2  Ga                                        EtOCH.sub.2 CH.sub.2                                                                       Et           Et          Ga                                        EtOCH.sub.2 CH.sub.2                                                                       Pr-n         Pr-n        Gb                                        EtOCH.sub.2 CH.sub.2                                                                       (CH.sub.2).sub.4     Ga                                            EtOCH.sub.2 CH.sub.2                                                                       (CH.sub.2).sub.5     Ga                                            MeOCH.sub.2 (CH.sub.3)CH                                                                   H            Me          Gc                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   H            Et          Gc                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Me          Ga                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Et          Ga                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Pr-n        Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Pr-i        Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Bu-n        Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph          Ga                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-Cl     Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-OMe    Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-CF.sub.3                                                                              Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-NO.sub.2                                                                              Gb                                        MeOCH.sub.2 (CH.sub. 3)CH                                                                  Me           Ph-2-Me     Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Me           PhCH.sub.2  Ga                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Et           Et          Ga                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   Pr-n         Pr-n        Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                   (CH.sub.2).sub.4     Ga                                            MeOCH.sub.2 (CH.sub.3)CH                                                                   (CH.sub.2).sub.5     Ga                                            EtOCH.sub.2 (CH.sub.3)CH                                                                   H            Me          Gc                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   H            Et          Gc                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Me          Ga                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Et          Ga                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Pr-n        Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Pr-i        Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Bu-n        Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph          Ga                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-Cl     Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-OMe    Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-CF.sub.3                                                                              Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-NO.sub.2                                                                              Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           Ph-2-Me     Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Me           PhCH.sub.2  Ga                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   Et           Et          Ga                                        EtOCH.sub.2 (CH.sub.3 )CH                                                                  Pr-n         Pr-n        Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                   (CH.sub.2).sub.4     Ga                                            EtOCH.sub.2 (CH.sub.3)CH                                                                   (CH.sub.2).sub.5     Ga                                            CHF.sub.2 OCH.sub.2                                                                        H            Me          Gc                                        CHF.sub.2 OCH.sub.2                                                                        H            Et          Gc                                        CHF.sub.2 OCH.sub.2                                                                        Me           Me          Ga                                        CHF.sub.2 OCH.sub.2                                                                        Me           Et          Ga                                        CHF.sub.2 OCH.sub.2                                                                        Me           Pr-n        Gb                                        CHF.sub.2 OCH.sub.2                                                                        Me           Pr-i        Gb                                        CHF.sub.2 OCH.sub.2                                                                        Me           Bu-n        Gb                                        CHF.sub.2 OCH.sub.2                                                                        Me           Ph          Ga                                        CHF.sub.2 OCH.sub.2                                                                        Me           Ph-2-Cl     Gb                                        CHF.sub.2 OCH.sub.2                                                                        Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        CHF.sub.2 OCH.sub.2                                                                        Me           Ph-2-OMe    Gb                                        CHF.sub.2 OCH.sub.2                                                                        Me           Ph-2-CF.sub.3                                                                              Gb                                        CHF.sub.2 OCH.sub.2                                                                        Me           Ph-2-NO.sub.2                                                                              Gb                                        CHF.sub.2 OCH.sub.2                                                                        Me           Ph-2-Me     Gb                                        CHF.sub.2 OCH.sub.2                                                                        Me           PhCH.sub.2  Ga                                        CHF.sub.2 OCH.sub.2                                                                        Et           Et          Ga                                        CHF.sub.2 OCH.sub.2                                                                        Pr-n         Pr-n        Gb                                        CHF.sub.2 OCH.sub.2                                                                        (CH.sub.2).sub.4     Ga                                            CHF.sub.2 OCH.sub.2                                                                        (CH.sub.2).sub.5     Ga                                            MeSCH.sub.2 Me           Me          Ga                                        MeSCH.sub.2 Me           Et          Ga                                        MeSCH.sub. 2                                                                               Me           Ph          Ga                                        MeSCH.sub.2 Me           PhCH.sub.2  Ga                                        MeSCH.sub.2 Et           Et          Ga                                        MeSCH.sub.2 Pr-n         Pr-n        Gb                                        MeSCH.sub.2 (CH.sub.2).sub.4     Ga                                            MeSCH.sub.2 (CH.sub.2).sub.5     Ga                                            EtSCH.sub.2 Me           Me          Ga                                        EtSCH.sub.2 Me           Et          Ga                                        EtSCH.sub.2 Me           Ph          Ga                                        EtSCH.sub.2 Me           PhCH.sub.2  Ga                                        EtSCH.sub.2 Et           Et          Ga                                        EtSCH.sub.2 Pr-n         Pr-n        Gb                                        EtSCH.sub.2 (CH.sub.2).sub.4     Ga                                            EtSCH.sub.2 (CH.sub.2).sub.5     Ga                                            MeSCH.sub.2 CH.sub.2                                                                       H            Me          Gc                                        MeSCH.sub.2 CH.sub.2                                                                       H            Et          Gc                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Me          Ga                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Et          Ga                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Pr-n        Gb                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Pr-i        Gb                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Bu-n        Gb                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Ph          Ga                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-Cl     Gb                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-OMe    Gb                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-CF.sub.3                                                                              Gb                                        MeSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-NO.sub.2                                                                              Gb                                        MeSCH.sub.2 CH.sub. 2                                                                      Me           Ph-2-Me     Gb                                        MeSCH.sub.2 CH.sub.2                                                                       Me           PhCH.sub.2  Ga                                        MeSCH.sub.2 CH.sub.2                                                                       Et           Et          Ga                                        MeSCH.sub.2 CH.sub.2                                                                       Pr-n         Pr-n        Gb                                        MeSCH.sub.2 CH.sub.2                                                                       (CH.sub.2).sub.4     Ga                                            MeSCH.sub.2 CH.sub.2                                                                       (CH.sub.2).sub.5     Ga                                            EtSCH.sub.2 CH.sub.2                                                                       H            Me          Gc                                        EtSCH.sub.2 CH.sub.2                                                                       H            Et          Gc                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Me          Ga                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Et          Ga                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Pr-n        Gb                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Pr-i        Gb                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Bu-n        Gb                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Ph          Ga                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-Cl     Gb                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-OMe    Gb                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-CF.sub.3                                                                              Gb                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-NO.sub.2                                                                              Gb                                        EtSCH.sub.2 CH.sub.2                                                                       Me           Ph-2-Me     Gb                                        EtSCH.sub.2 CH.sub.2                                                                       Me           PhCH.sub.2  Ga                                        EtSCH.sub.2 CH.sub.2                                                                       Et           Et          Ga                                        EtSCH.sub.2 CH.sub.2                                                                       Pr-n         Pr-n        Gb                                        EtSCH.sub.2 CH.sub.2                                                                       (CH.sub.2).sub.4     Ga                                            EtSCH.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.5    Ga                                            MeSO.sub.2 CH.sub.2                                                                        Me           Me          Ga                                        MeSO.sub.2 CH.sub.2                                                                        Me           Et          Ga                                        MeSO.sub.2 CH.sub.2                                                                        Me           Ph          Ga                                        MeSO.sub.2 CH.sub.2                                                                        Me           PhCH.sub.2  Ga                                        MeSO.sub.2 CH.sub.2                                                                        Et           Et          Ga                                        MeSO.sub.2 CH.sub.2                                                                        Pr-n         Pr-n        Gb                                        MeSO.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.4     Ga                                            MeSO.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.5     Ga                                            EtSO.sub.2 CH.sub.2                                                                        Me           Me          Ga                                        EtSO.sub.2 CH.sub.2                                                                        Me           Et          Ga                                        EtSO.sub.2 CH.sub.2                                                                        Me           Ph          Ga                                        EtSO.sub.2 CH.sub.2                                                                        Me           PhCH.sub.2  Ga                                        EtSO.sub.2 CH.sub.2                                                                        Et           Et          Ga                                        EtSO.sub.2 CH.sub.2                                                                        Pr-n         Pr-n        Gb                                        EtSO.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.4     Ga                                            EtSO.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.5     Ga                                            MeSO.sub.2 CH.sub.2 CH.sub.2                                                               H            Me          Gc                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               H            Et          Gc                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Me          Ga                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Et          Ga                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Pr-n        Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Pr-i        Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Bu-n        Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph          Ga                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-Cl     Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-OMe    Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-CF.sub.3                                                                              Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-NO.sub.2                                                                              Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-Me     Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           PhCH.sub.2  Ga                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Et           Et          Ga                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               Pr-n         Pr-n        Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                               (CH.sub.2).sub.4     Ga                                            MeSO.sub.2 CH.sub.2 CH.sub.2                                                               (CH.sub.2).sub.5     Ga                                            EtSO.sub.2 CH.sub.2 CH.sub.2                                                               H            Me          Gc                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               H            Et          Gc                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Me          Ga                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Et          Ga                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Pr-n        Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Pr-i        Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Bu-n        Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph          Ga                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-Cl     Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-OMe    Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-CF.sub.3                                                                              Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-NO.sub.2                                                                              Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           Ph-2-Me     Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Me           PhCH.sub.2  Ga                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Et           Et          Ga                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               Pr-n         Pr-n        Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                               (CH.sub.2).sub.4     Ga                                            EtSO.sub.2 CH.sub.2 CH.sub.2                                                               (CH.sub.2).sub.5     Ga                                            FCH.sub.2   Me           Me          Ga                                        FCH.sub.2   Me           Et          Ga                                        FCH.sub.2   Me           Ph          Ga                                        FCH.sub.2   Me           PhCH.sub.2  Ga                                        FCH.sub.2   Et           Et          Ga                                        FCH.sub.2   Pr-n         Pr-n        Gb                                        FCH.sub.2   (CH.sub.2).sub.4     Ga                                            FCH.sub.2   (CH.sub.2).sub.5     Ga                                            ClCH.sub.2  Me           Me           Ga                                       ClCH.sub.2  Me           Et          Ga                                        ClCH.sub.2  Me           Ph          Ga                                        ClCH.sub.2  Me           PhCH.sub.2  Ga                                        ClCH.sub.2  Et           Et          Ga                                        ClCH.sub.2  Pr-n         Pr-n        Gb                                        ClCH.sub.2  (CH.sub.2).sub.4     Ga                                            ClCH.sub.2  (CH.sub.2).sub.5     Ga                                            BrCH.sub.2  Me           Me          Ga                                        BrCH.sub.2  Me           Et          Ga                                        BrCH.sub.2  Me           Ph          Ga                                        BrCH.sub.2  Me           PhCH.sub.2  Ga                                        BrCH.sub.2  Et           Et          Ga                                        BrCH.sub.2  Pr-n         Pr-n        Gb                                        BrCH.sub.2  (CH.sub.2).sub.4     Ga                                            BrCH.sub.2  (CH.sub.2).sub.5     Ga                                            ICH.sub.2   Me           Me          Ga                                        ICH.sub.2   Me           Et          Ga                                        ICH.sub.2   Me           Ph          Ga                                        ICH.sub.2   Me           PhCH.sub.2  Ga                                        ICH.sub.2   Et           Et          Ga                                        ICH.sub.2   Pr-n         Pr-n        Gb                                        ICH.sub.2   (CH.sub.2).sub.4     Ga                                            ICH.sub.2   (CH.sub.2).sub.5     Ga                                            FCH.sub.2 CH.sub.2                                                                         H            Me          Gc                                        FCH.sub.2 CH.sub.2                                                                         H            Et          Gc                                        FCH.sub.2 CH.sub.2                                                                         Me           Me          Ga                                        FCH.sub.2 CH.sub.2                                                                         Me           Et          Ga                                        FCH.sub.2 CH.sub.2                                                                         Me           Pr-n        Gb                                        FCH.sub.2 CH.sub.2                                                                         Me           Pr-i        Gb                                        FCH.sub.2 CH.sub.2                                                                         Me           Bu-n        Gb                                        FCH.sub.2 CH.sub.2                                                                         Me           Ph          Ga                                        FCH.sub.2 CH.sub.2                                                                         Me           Ph-2-Cl     Gb                                        FCH.sub.2 CH.sub.2                                                                         Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        FCH.sub.2 CH.sub.2                                                                         Me           Ph-2-OMe    Gb                                        FCH.sub.2 CH.sub.2                                                                         Me           Ph-2-CF.sub.3                                                                              Gb                                        FCH.sub.2 CH.sub.2                                                                         Me           Ph-2-NO.sub.2                                                                              Gb                                        FCH.sub.2 CH.sub.2                                                                         Me           Ph-2-Me     Gb                                        FCH.sub.2 CH.sub.2                                                                         Me           PhCH.sub.2  Ga                                        FCH.sub.2 CH.sub.2                                                                         Et           Et          Ga                                        FCH.sub.2 CH.sub.2                                                                         Pr-n         Pr-n        Gb                                        FCH.sub.2 CH.sub.2                                                                         (CH.sub.2).sub.4     Ga                                            FCH.sub.2 CH.sub.2                                                                         (CH.sub.2).sub.5     Ga                                            ClCH.sub.2 CH.sub.2                                                                        H            Me          Gc                                        ClCH.sub.2 CH.sub.2                                                                        H            Et          Gc                                        ClCH.sub.2 CH.sub.2                                                                        Me           Me          Ga                                        ClCH.sub.2 CH.sub.2                                                                        Me           Et          Ga                                        ClCH.sub.2 CH.sub.2                                                                        Me           Pr-n        Gb                                        ClCH.sub.2 CH.sub.2                                                                        Me           Pr-i        Gb                                        ClCH.sub.2 CH.sub.2                                                                        Me           Bu-n        Gb                                        ClCH.sub.2 CH.sub.2                                                                        Me           Ph          Ga                                        ClCH.sub.2 CH.sub.2                                                                        Me           Ph-2-Cl     Gb                                        ClCH.sub.2 CH.sub.2                                                                        Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        ClCH.sub.2 CH.sub.2                                                                        Me           Ph-2-OMe    Gb                                        ClCH.sub. 2 CH.sub.2                                                                       Me           Ph-2-CF.sub.3                                                                              Gb                                        ClCH.sub.2 CH.sub.2                                                                        Me           Ph-2-NO.sub.2                                                                              Gb                                        ClCH.sub.2 CH.sub.2                                                                        Me           Ph-2-Me     Gb                                        ClCH.sub.2 CH.sub.2                                                                        Me           PhCH.sub.2  Ga                                        ClCH.sub.2 CH.sub.2                                                                        Et           Et          Ga                                        ClCH.sub.2 CH.sub.2                                                                        Pr-n         Pr-n        Gb                                        ClCH.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.4     Ga                                            ClCH.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.5     Ga                                            BrCH.sub.2 CH.sub.2                                                                        H            Me          Gc                                        BrCH.sub.2 CH.sub.2                                                                        H            Et          Gc                                        BrCH.sub.2 CH.sub.2                                                                        Me           Me          Ga                                        BrCH.sub.2 CH.sub.2                                                                        Me           Et          Ga                                        BrCH.sub.2 CH.sub.2                                                                        Me           Pr-n        Gb                                        BrCH.sub.2 CH.sub.2                                                                        Me           Pr-i        Gb                                        BrCH.sub.2 CH.sub.2                                                                        Me           Bu-n        Gb                                        BrCH.sub.2 CH.sub.2                                                                        Me           Ph          Ga                                        BrCH.sub.2 CH.sub.2                                                                        Me           Ph-2-Cl     Gb                                        BrCH.sub.2 CH.sub.2                                                                        Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        BrCH.sub.2 CH.sub.2                                                                        Me           Ph-2-OMe    Gb                                        BrCH.sub.2 CH.sub.2                                                                        Me           Ph-2-CF.sub.3                                                                              Gb                                        BrCH.sub.2 CH.sub.2                                                                        Me           Ph-2-NO.sub.2                                                                              Gb                                        BrCH.sub.2 CH.sub.2                                                                        Me           Ph-2-Me     Gb                                        BrCH.sub.2 CH.sub.2                                                                        Me           PhCH.sub.2  Ga                                        BrCH.sub.2 CH.sub.2                                                                        Et           Et          Ga                                        BrCH.sub.2 CH.sub.2                                                                        Pr-n         Pr-n        Gb                                        BrCH.sub. 2 CH.sub.2                                                                       (CH.sub.2).sub.4     Ga                                            BrCH.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.5     Ga                                            ICH.sub.2 CH.sub.2                                                                         H            Me          Gc                                        ICH.sub.2 CH.sub.2                                                                         H            Et          Gc                                        ICH.sub.2 CH.sub.2                                                                         Me           Me          Ga                                        ICH.sub.2 CH.sub.2                                                                         Me           Et          Ga                                        ICH.sub.2 CH.sub.2                                                                         Me           Pr-n        Gb                                        ICH.sub.2 CH.sub.2                                                                         Me           Pr-i        Gb                                        ICH.sub.2 CH.sub.2                                                                         Me           Bu-n        Gb                                        ICH.sub.2 CH.sub.2                                                                         Me           Ph          Ga                                        ICH.sub.2 CH.sub.2                                                                         Me           Ph-2-Cl     Gb                                        ICH.sub.2 CH.sub.2                                                                         Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        ICH.sub.2 CH.sub.2                                                                         Me           Ph-2-OMe    Gb                                        ICH.sub.2 CH.sub.2                                                                         Me           Ph-2-CF.sub.3                                                                              Gb                                        ICH.sub.2 CH.sub.2                                                                         Me           Ph-2-NO.sub.2                                                                              Gb                                        ICH.sub.2 CH.sub.2                                                                         Me           Ph-2-Me     Gb                                        ICH.sub.2 CH.sub.2                                                                         Me           PhCH.sub.2  Ga                                        ICH.sub.2 CH.sub.2                                                                         Et           Et          Ga                                        ICH.sub.2 CH.sub.2                                                                         Pr-n         Pr-n        Gb                                        ICH.sub.2 CH.sub.2                                                                         (CH.sub.2).sub.4     Ga                                            ICH.sub.2 CH.sub.2                                                                         (CH.sub.2).sub.5     Ga                                            FCH.sub.2 (CH.sub.3)CH                                                                     Me           Me          Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                     Me           Et          Ga                                        FCH.sub.2 (CH.sub. 3)CH                                                                    Me           Ph          Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                     Me           PhCH.sub.2  Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                     Et           Et          Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                     Pr-n         Pr-n        Gb                                        FCH.sub.2 (CH.sub.3)CH                                                                     (CH.sub.2).sub.4     Ga                                            FCH.sub.2 (CH.sub.3)CH                                                                     (CH.sub.2).sub.5     Ga                                            ClCH.sub.2 (CH.sub.3)CH                                                                    Me           Me          Ga                                        ClCH.sub.2 (CH.sub.3)CH                                                                    Me           Et          Ga                                        ClCH.sub.2 (CH.sub.3)CH                                                                    Me           Ph          Ga                                        ClCH.sub.2 (CH.sub.3)CH                                                                    Me           PhCH.sub.2  Ga                                        ClCH.sub.2 (CH.sub.3)CH                                                                    Et           Et          Ga                                        ClCH.sub.2 (CH.sub.3)CH                                                                    Pr-n         Pr-n        Gb                                        ClCH.sub.2 (CH.sub.3)CH                                                                    (CH.sub.2).sub.4     Ga                                            ClCH.sub.2 (CH.sub.3)CH                                                                    (CH.sub.2).sub.5     Ga                                            BrCH.sub.2 (CH.sub.3)CH                                                                    Me           Me          Ga                                        BrCH.sub.2 (CH.sub.3)CH                                                                    Me           Et          Ga                                        BrCH.sub.2 (CH.sub.3)CH                                                                    Me           Ph          Ga                                        BrCH.sub.2 (CH.sub.3)CH                                                                    Me           PhCH.sub.2  Ga                                        BrCH.sub.2 (CH.sub.3)CH                                                                    Et           Et          Ga                                        BrCH.sub.2 (CH.sub.3)CH                                                                    Pr-n         Pr-n        Gb                                        BrCH.sub.2 (CH.sub.3)CH                                                                     (CH.sub.2).sub.4    Ga                                            BrCH.sub.2 (CH.sub.3)CH                                                                    (CH.sub.2).sub.5     Ga                                            ICH.sub.2 (CH.sub.3)CH                                                                     Me           Me          Ga                                        ICH.sub.2 (CH.sub.3)CH                                                                     Me           Et          Ga                                        ICH.sub.2 (CH.sub.3)CH                                                                     Me           Ph          Ga                                        ICH.sub.2 (CH.sub.3)CH                                                                     Me           PhCH.sub.2  Ga                                        ICH.sub.2 (CH.sub.3)CH                                                                     Et           Et          Ga                                        ICH.sub.2 (CH.sub.3)CH                                                                     Pr-n         Pr-n        Gb                                        ICH.sub.2 (CH.sub.3)CH                                                                     (CH.sub.2).sub.4     Ga                                            ICH.sub.2 (CH.sub.3)CH                                                                     (CH.sub.2).sub.5     Ga                                            CF.sub.3 CH.sub.2                                                                          H            Me          Gc                                        CF.sub.3 CH.sub.2                                                                          H            Et          Gc                                        CF.sub.3 CH.sub.2                                                                          Me           Me          Ga                                        CF.sub.3 CH.sub.2                                                                          Me           Et          Ga                                        CF.sub.3 CH.sub.2                                                                          Me           Pr-n        Gb                                        CF.sub.3 CH.sub.2                                                                          Me           Pr-i        Gb                                        CF.sub.3 CH.sub.2                                                                          Me           Bu-n        Gb                                        CF.sub.3 CH.sub.2                                                                          Me           Ph          Ga                                        CF.sub.3 CH.sub.2                                                                          Me           Ph-2-Cl     Gb                                        CF.sub.3 CH.sub.2                                                                          Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        CF.sub.3 CH.sub.2                                                                          Me           Ph-2-OMe    Gb                                        CF.sub.3 CH.sub.2                                                                          Me           Ph-2-CF.sub.3                                                                              Gb                                        CF.sub.3 CH.sub.2                                                                          Me           Ph-2-NO.sub.2                                                                              Gb                                        CF.sub.3 CH.sub.2                                                                          Me           Ph-2-Me     Gb                                        CF.sub.3 CH.sub.2                                                                          Me           PhCH.sub.2  Ga                                        CF.sub.3 CH.sub.2                                                                          Et           Et          Ga                                        CF.sub.3 CH.sub.2                                                                          Pr-n         Pr-n        Gb                                        CF.sub.3 CH.sub.2                                                                          (CH.sub.2).sub.4     Ga                                            CF.sub.3 CH.sub.2                                                                          (CH.sub.2).sub.5     Ga                                            NCCH.sub.2  H            Me          Gc                                        NCCH.sub.2  H            Et          Gc                                        NCCH.sub.2  Me           Me          Ga                                        NCCH.sub.2  Me           Et          Ga                                        NCCH.sub.2  Me           Pr-n        Gb                                        NCCH.sub.2  Me           Pr-i        Gb                                        NCCH.sub.2  Me           Bu-n        Gb                                        NCCH.sub.2  Me           Ph          Ga                                        NCCH.sub.2  Me           Ph-2-Cl     Gb                                        NCCH.sub.2  Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        NCCH.sub.2  Me           Ph-2-OMe    Gb                                        NCCH.sub.2  Me           Ph-2-CF.sub.3                                                                              Gb                                        NCCH.sub.2  Me           Ph-2-NO.sub.2                                                                              Gb                                        NCCH.sub.2  Me           Ph-2-Me     Gb                                        NCCH.sub.2  Me           PhCH.sub.2  Ga                                        NCCH.sub.2  Et           Et          Ga                                        NCCH.sub.2  Pr-n         Pr-n        Gb                                        NCCH.sub.2  (CH.sub.2).sub.4     Ga                                            NCCH.sub.2  (CH.sub.2).sub.5     Ga                                            NCCH.sub.2 CH.sub.2                                                                        H            Me          Gc                                        NCCH.sub.2 CH.sub.2                                                                        H            Et          Gc                                        NCCH.sub.2 CH.sub.2                                                                        Me           Me          Ga                                        NCCH.sub.2 CH.sub.2                                                                        Me           Et          Ga                                        NCCH.sub.2 CH.sub.2                                                                        Me           Pr-n        Gb                                        NCCH.sub.2 CH.sub.2                                                                        Me           Pr-i        Gb                                        NCCH.sub.2 CH.sub.2                                                                        Me           Bu-n        Gb                                        NCCH.sub.2 CH.sub.2                                                                        Me           Ph          Ga                                        NCCH.sub.2 CH.sub.2                                                                        Me           Ph-2-Cl     Gb                                        NCCH.sub.2 CH.sub.2                                                                        Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        NCCH.sub.2 CH.sub.2                                                                        Me           Ph-2-OMe    Gb                                        NCCH.sub.2 CH.sub.2                                                                        Me           Ph-2-CF.sub.3                                                                              Gb                                        NCCH.sub.2 CH.sub.2                                                                        Me           Ph-2-NO.sub.2                                                                              Gb                                        NCCH.sub.2 CH.sub.2                                                                        Me           Ph-2-Me     Gb                                        NCCH.sub.2 CH.sub.2                                                                        Me           PhCH.sub.2  Ga                                        NCCH.sub.2 CH.sub.2                                                                        Et           Et          Ga                                        NCCH.sub.2 CH.sub.2                                                                        Pr-n         Pr-n        Gb                                        NCCH.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.4     Ga                                            NCCH.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.5     Ga                                            MeO.sub.2 CCH.sub.2                                                                        H            Me          Gc                                        MeO.sub.2 CCH.sub.2                                                                        H            Et          Gc                                        MeO.sub.2 CCH.sub.2                                                                        Me           Me          Ga                                        MeO.sub.2 CCH.sub.2                                                                        Me           Et          Ga                                        MeO.sub.2 CCH.sub.2                                                                        Me           Pr-n        Gb                                        MeO.sub.2 CCH.sub.2                                                                        Me           Pr-i        Gb                                        MeO.sub.2 CCH.sub.2                                                                        Me           Bu-n        Gb                                        MeO.sub.2 CCH.sub.2                                                                        Me           Ph          Ga                                        MeO.sub.2 CCH.sub.2                                                                        Me           Ph-2-Cl     Gb                                        MeO.sub.2 CCH.sub.2                                                                        Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        MeO.sub.2 CCH.sub.2                                                                        Me           Ph-2-OMe    Gb                                        MeO.sub.2 CCH.sub.2                                                                        Me           Ph-2-CF.sub.3                                                                              Gb                                        MeO.sub.2 CCH.sub.2                                                                        Me           Ph-2-NO.sub.2                                                                              Gb                                        MeO.sub.2 CCH.sub.2                                                                        Me           Ph-2-Me     Gb                                        MeO.sub.2 CCH.sub.2                                                                        Me           PhCH.sub.2  Ga                                        MeO.sub.2 CCH.sub.2                                                                        Et           Et          Ga                                        MeO.sub.2 CCH.sub.2                                                                        Pr-n         Pr-n        Gb                                        MeO.sub.2 CCH.sub.2                                                                        (CH.sub.2).sub.4     Ga                                            MeO.sub.2 CCH.sub.2                                                                        (CH.sub.2).sub.5     Ga                                            EtO.sub.2 CCH.sub.2                                                                        H            Me          Gc                                        EtO.sub.2 CCH.sub.2                                                                        H            Et          Gc                                        EtO.sub.2 CCH.sub.2                                                                        Me           Me          Ga                                        EtO.sub.2 CCH.sub.2                                                                        Me           Et          Ga                                        EtO.sub.2 CCH.sub.2                                                                        Me           Pr-n        Gb                                        EtO.sub.2 CCH.sub.2                                                                        Me           Pr-i        Gb                                        EtO.sub.2 CCH.sub.2                                                                        Me           Bu-n        Gb                                        EtO.sub.2 CCH.sub.2                                                                        Me           Ph          Ga                                        EtO.sub.2 CCH.sub.2                                                                        Me           Ph-2-Cl     Gb                                        EtO.sub.2 CCH.sub.2                                                                        Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        EtO.sub.2 CCH.sub.2                                                                        Me           Ph-2-OMe    Gb                                        EtO.sub.2 CCH.sub.2                                                                        Me           Ph-2-CF.sub.3                                                                              Gb                                        EtO.sub.2 CCH.sub.2                                                                        Me           Ph-2-NO.sub.2                                                                              Gb                                        EtO.sub.2 CCH.sub.2                                                                        Me           Ph-2-Me     Gb                                        EtO.sub.2 CCH.sub.2                                                                        Me           PhCH.sub.2  Ga                                        EtO.sub.2 CCH.sub.2                                                                        Et           Et          Ga                                        EtO.sub.2 CCH.sub.2                                                                        Pr-n         Pr-n        Gb                                        EtO.sub.2 CCH.sub.2                                                                        (CH.sub.2).sub.4     Ga                                            EtO.sub.2 CCH.sub.2                                                                        (CH.sub.2).sub.5     Ga                                            Pr-nO.sub.2 CCH.sub.2                                                                      Me           Me          Ga                                        Pr-nO.sub.2 CCH.sub.2                                                                      Me           Et          Ga                                        Pr-nO.sub.2 CCH.sub.2                                                                      Me           Ph          Ga                                        Pr-nO.sub.2 CCH.sub.2                                                                      Me           PhCH.sub.2  Ga                                        Pr-nO.sub.2 CCH.sub.2                                                                      Et           Et          Ga                                        Pr-nO.sub.2 CCH.sub.2                                                                      Pr-n         Pr-n        Gb                                        Pr-nO.sub.2 CCH.sub.2                                                                      (CH.sub.2).sub.4     Ga                                            Pr-nO.sub.2 CCH.sub.2                                                                      (CH.sub.2).sub.5     Ga                                            MeO.sub.2 CCH.sub.2 CH.sub.2                                                               H            Me          Gc                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               H            Et          Gc                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Me          Ga                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Et          Ga                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Pr-n        Gb                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Pr-i        Gb                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Bu-n        Gb                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph          Ga                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-Cl     Gb                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-OMe    Gb                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-CF.sub.3                                                                              Gb                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-NO.sub.2                                                                              Gb                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-Me     Gb                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           PhCH.sub.2  Ga                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Et           Et          Ga                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               Pr-n         Pr-n        Gb                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                               (CH.sub.2).sub.4     Ga                                            MeO.sub.2 CCH.sub.2 CH.sub.2                                                               (CH.sub.2).sub.5     Ga                                            EtO.sub.2 CCH.sub.2 CH.sub.2                                                               H            Me          Gc                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               H            Et          Gc                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Me          Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Et          Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Pr-n        Gb                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Pr-i        Gb                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Bu-n        Gb                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph          Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-Cl     Gb                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-OMe    Gb                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-CF.sub.3                                                                              Gb                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-NO.sub.2                                                                              Gb                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           Ph-2-Me     Gb                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Me           PhCH.sub.2  Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Et           Et          Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               Pr-n         Pr-n        Gb                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                               (CH.sub.2).sub.4     Ga                                            EtO.sub.2 CCH.sub.2 CH.sub.2                                                               (CH.sub.2).sub.5     Ga                                            Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                             Me           Me          Ga                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                             Me           Et          Ga                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                             Me           Ph          Ga                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                             Me           PhCH.sub.2  Ga                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                             Et           Et          Ga                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                             Pr-n         Pr-n        Gb                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                             (CH.sub.2).sub.4     Ga                                            Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                             (CH.sub.2).sub.5     Ga                                            MeCOCH.sub.2                                                                               Me           Me          Ga                                        MeCOCH.sub.2                                                                               Me           Et          Ga                                        MeCOCH.sub.2                                                                               Me           Ph          Ga                                        MeCOCH.sub.2                                                                               Me           PhCH.sub.2  Ga                                        MeCOCH.sub.2                                                                               Et           Et          Ga                                        MeCOCH.sub.2                                                                               Pr-n         Pr-n        Gb                                        MeCOCH.sub.2                                                                               (CH.sub.2).sub.4     Ga                                            MeCOCH.sub.2                                                                               (CH.sub.2).sub.5     Ga                                            EtCOCH.sub.2                                                                               Me           Me          Ga                                        EtCOCH.sub.2                                                                               Me           Et          Ga                                        EtCOCH.sub.2                                                                               Me           Ph          Ga                                        EtCOCH.sub.2                                                                               Me           PhCH.sub.2  Ga                                        EtCOCH.sub.2                                                                               Et           Et          Ga                                        EtCOCH.sub.2                                                                               Pr-n         Pr-n        Gb                                        EtCOCH.sub.2                                                                               (CH.sub.2).sub.4     Ga                                            EtCOCH.sub.2                                                                               (CH.sub.2).sub.5     Ga                                            PhCH.sub.2  H            Me          Gc                                        PhCH.sub.2  H            Et          Gc                                        PhCH.sub.2  Me           Me          Ga                                        PhCH.sub.2  Me           Et          Ga                                        PhCH.sub.2  Me           Pr-n        Gb                                        PhCH.sub.2  Me           Pr-i        Gb                                        PhCH.sub.2  Me           Bu-n        Gb                                        PhCH.sub.2  Me           Ph          Ga                                        PhCH.sub.2  Me           Ph-2-Cl     Gb                                        PhCH.sub.2  Me           Ph-2-CO.sub.2 Me                                                                           Gb                                        PhCH.sub.2  Me           Ph-2-OMe    Gb                                        PhCH.sub.2  Me           Ph-2-CF.sub.3                                                                              Gb                                        PhCH.sub.2  Me           Ph-2-NO.sub.2                                                                              Gb                                        PhCH.sub.2  Me           Ph-2-Me     Gb                                        PhCH.sub.2  Me           PhCH.sub.2  Ga                                        PhCH.sub.2  Et           Et          Ga                                        PhCH.sub.2  Pr-n         Pr-n        Gb                                        PhCH.sub.2  (CH.sub.2).sub.4     Ga                                            PhCH.sub. 2 (CH.sub.2).sub.5     Ga                                            Ph          Me           Me          Ga                                        Ph          Me           Et          Ga                                        Ph          (CH.sub.2).sub.4     Ga                                            Ph          (CH.sub.2).sub.5     Ga                                            Me          CH.sub.2CHCH.sub.2                                                                          Me          Ga                                        Et          CH.sub.2CHCH.sub.2                                                                          Me          Ga                                        Me          CH CCH.sub.2 Me          Ga                                        Et          CH CCH.sub.2 Me          Ga                                        Me          CH.sub.2CHCH.sub.2                                                                          CH.sub.2CHCH.sub.2                                                                         Ga                                        Et          CH.sub.2CHCH.sub.2                                                                          CH.sub.2CHCH.sub.2                                                                         Ga                                        Me          CH CCH.sub.2 CH CCH.sub.2                                                                               Ga                                        Et          CH CCH.sub.2 CH CCH.sub.2                                                                               Ga                                        Me          H            H           Gb                                        Et          H            H           Gb                                        Bu-i        Me           Me          Gb                                        cyc-Bu      Me           Me          Gb                                        cyc-Pen     Me           Me          Gc                                        cyc-Hex     Me           Me          Gc                                        Ph-2-Me     Me           Me          Gb                                        Ph-3-Me     Me           Me          Gb                                        Ph-4-OMe    Me           Me          Gb                                        Ph-3-OMe    Me           Me          Gb                                        Ph-2-OMe    Me           Me          Gb                                        Ph-4-Cl     Me           Me          Gb                                        Ph-3-Cl     Me           Me          Gb                                        Ph-2-Cl     Me           Me          Gb                                        Ph-2,6-Cl.sub.2                                                                            Me           Me          Gb                                        ______________________________________                                    

                  TABLE 2                                                          ______________________________________                                          ##STR145##                                                                    R.sup.11    R.sup.12   R.sup.13   Gn                                           ______________________________________                                         Me          H          Me         Gc                                           Me          H          Et         Gc                                           Me          Me         Me         Ga                                           Me          Me         Et         Ga                                           Me          Me         Pr-n       Gb                                           Me          Me         Pr-i       Gb                                           Me          Me         Bu-n       Gb                                           Me          Me         Ph         Ga                                           Me          Me         Ph-2-Cl    Gb                                           Me          Me         Ph-2-CO.sub.2 Me                                                                          Gb                                           Me          Me         Ph-2-OMe   Gb                                           Me          Me         Ph-2-CF.sub.3                                                                             Gb                                           Me          Me         Ph-2-NO.sub.2                                                                             Gb                                           Me          Me         Ph-2-Me    Gb                                           Me          Me         Ph-CH.sub.2                                                                               Ga                                           Me          Et         Et         Ga                                           Me          Pr-n       Pr-n       Gb                                           Me          (CH.sub.2).sub.4  Ga                                               Me          (CH.sub.2).sub.5  Ga                                               Et          H          Me         Gc                                           Et          H          Et         Gc                                           Et          Me         Me         Ga                                           Et          Me         Et         Ga                                           Et          Me         Pr-n       Gb                                           Et          Me         Pr-i       Gb                                           Et          Me         Bu-n       Gb                                           Et          Me         Ph         Ga                                           Et          Me         Ph-2-Cl    Gb                                           Et          Me         Ph-2-CO.sub.2 Me                                                                          Gb                                           Et          Me         Ph-2-OMe   Gb                                           Et          Me         Ph-2-CF.sub.3                                                                             Gb                                           Et          Me         Ph-2-NO.sub.2                                                                             Gb                                           Et          Me         Ph-2-Me    Gb                                           Et          Me         PhCH.sub.2 Ga                                           Et          Et         Et         Ga                                           Et          Pr-n       Pr-n       Gb                                           Et          (CH.sub.2).sub.4  Ga                                               Et          (CH.sub.2).sub.5  Ga                                               Pr-n        H          Me         Gc                                           Pr-n        H          Et         Gc                                           Pr-n        Me         Me         Ga                                           Pr-n        Me         Et         Ga                                           Pr-n        Me         Ph         Ga                                           Pr-n        Me         PhCH.sub.2 Ga                                           Pr-n        Et         Et         Ga                                           Pr-n        Pr-n       Pr-n       Gb                                           Pr-n        (CH.sub.2).sub.4  Ga                                               Pr-n        (CH.sub.2).sub.5  Ga                                               CH.sub.2CHCH.sub.2                                                                         H          Me         Gc                                           CH.sub.2CHCH.sub.2                                                                         H          Et         Gc                                           CH.sub.2CHCH.sub.2                                                                         Me         Me         Ga                                           CH.sub.2CHCH.sub.2                                                                         Me         Et         Ga                                           CH.sub.2CHCH.sub.2                                                                         Me         Pr-n       Gb                                           CH.sub.2CHCH.sub.2                                                                         Me         Pr-i       Gb                                           CH.sub.2CHCH.sub.2                                                                         Me         Bu-n       Gb                                           CH.sub.2CHCH.sub.2                                                                         Me         Ph         Ga                                           CH.sub.2CHCH.sub.2                                                                         Me         Ph-2-Cl    Gb                                           CH.sub.2CHCH.sub.2                                                                         Me         Ph-2-CO.sub.2 Me                                                                          Gb                                           CH.sub.2CHCH.sub.2                                                                         Me         Ph-2-OMe   Gb                                           CH.sub.2CHCH.sub.2                                                                         Me         Ph-2-CF.sub.3                                                                             Gb                                           CH.sub.2CHCH.sub.2                                                                         Me         Ph-2-NO.sub.2                                                                             Gb                                           CH.sub.2CHCH.sub.2                                                                         Me         Ph-2-Me    Gb                                           CH.sub. 2CHCH.sub.2                                                                        Me         PhCH.sub.2 Ga                                           CH.sub.2CHCH.sub.2                                                                         Et         Et         Ga                                           CH.sub.2CHCH.sub.2                                                                         Pr-n       pr-n       Gb                                           CH.sub.2CHCH.sub.2                                                                         (CH.sub.2).sub.4  Ga                                               CH.sub.2CHCH.sub.2                                                                         (CH.sub.2).sub.5  Ga                                               Ph          Me         Me          Ga                                          Ph          Me         Et          Ga                                          Ph          (CH.sub.2).sub.4  Ga                                               Ph          (CH.sub.2).sub.5  Ga                                               CHCCH.sub.2 Me         Me         Ga                                           MeOCH.sub.2 Me         Me         Ga                                           MeSCH.sub.2 Me         Me         Ga                                           MeO.sub.2 CCH.sub.2                                                                        Me         Me         Ga                                           Pr-i        Me         Me         Gb                                           PhCH.sub.2  Me         Me         Gc                                           ______________________________________                                    

                  TABLE 3                                                          ______________________________________                                          ##STR146##                                                                    R.sup.11        R.sup.12     R.sup.13                                                                               Gn                                        ______________________________________                                         H               Me           Me      Ga                                        Me              Me           Me      Ga                                        Et              Me           Me      Ga                                        Pr-n            Me           Me      Gb                                        Pr-i            Me           Me      Gb                                        cyc-Pr          Me           Me      Gb                                        cyc-PrCH.sub.2  Me           Me      Gb                                        Bu-n            Me           Me      Gb                                        Bu-sec          Me           Me      Gb                                        Bu-t            Me           Me      Gb                                        CH.sub.2CHCH.sub.2                                                                             Me           Me      Ga                                        CHCCH.sub.2     Me           Me      Ga                                        MeOCH.sub.2     Me           Me      Ga                                        EtOCH.sub.2     Me           Me      Gb                                        MeOCH.sub.2 CH.sub.2                                                                           Me           Me      Ga                                        EtOCH.sub.2 CH.sub.2                                                                           Me           Me      Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                       Me           Me      Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                       Me           Me      Gb                                        CHF.sub.2 OCH.sub.2                                                                            Me           Me      Ga                                        MeSCH.sub.2     Me           Me      Ga                                        EtSCH.sub.2     Me           Me      Gb                                        MeSCH.sub.2 CH.sub.2                                                                           Me           Me      Ga                                        EtSCH.sub.2 CH.sub.2                                                                           Me           Me      Gb                                        MeSO.sub.2 CH.sub.2                                                                            Me           Me      Ga                                        EtSO.sub.2 CH.sub.2                                                                            Me           Me      Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                                   Me           Me      Ga                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                                   Me           Me      Gb                                        FCH.sub.2       Me           Me      Ga                                        ClCH.sub.2      Me           Me      Ga                                        BrCH.sub.2      Me           Me      Ga                                        ICH.sub.2       Me           Me      Ga                                        FCH.sub.2 CH.sub.2                                                                             Me           Me      Ga                                        ClCH.sub.2 CH.sub.2                                                                            Me           Me      Ga                                        BrCH.sub.2 CH.sub.2                                                                            Me           Me      Ga                                        ICH.sub.2 CH.sub.2                                                                             Me           Me      Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                         Me           Me      Gb                                        ClCH.sub.2 (CH.sub.3)CH                                                                        Me           Me      Gb                                        BrCH.sub.2 (CH.sub.3)CH                                                                        Me           Me      Gb                                        ICH.sub.2 (CH.sub.3)CH                                                                         Me           Me      Gb                                        CF.sub.3 CH.sub.2                                                                              Me           Me      Ga                                        NCCH.sub.2      Me           Me      Ga                                        NCCH.sub.2 CH.sub.2                                                                            Me           Me      Ga                                        MeO.sub.2 CCH.sub.2                                                                            Me           Me      Ga                                        EtO.sub.2 CCH.sub.2                                                                            Me           Me      Gb                                        Pr-nO.sub.2 CCH.sub.2                                                                          Me           Me      Gc                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                                   Me           Me      Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                                   Me           Me      Gb                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                                 Me           Me      Gc                                        MeCOCH.sub.2    Me           Me      Ga                                        PhCH.sub.2      Me           Me      Ga                                        Ph              Me           Me      Ga                                        H               Me           Et      Ga                                        Me              Me           Et      Ga                                        Et              Me           Et      Ga                                        Pr-n            Me           Et      Gb                                        Pr-i            Me           Et      Gb                                        cyc-Pr          Me           Et      Gb                                        cyc-Pr CH.sub.2 Me           Et      Gb                                        Bu-n            Me           Et      Gb                                        Bu-sec          Me           Et      Ga                                        Bu-t            Me           Et      Ga                                        CH.sub.2CHCH.sub.2                                                                             Me           Et      Ga                                        CHCCH.sub.2     Me           Et      Gb                                        MeOCH.sub.2     Me           Et      Ga                                        EtOCH.sub.2     Me           Et      Ga                                        MeOCH.sub.2 CH.sub.2                                                                           Me           Et      Gb                                        EtOCH.sub.2 CH.sub.2                                                                           Me           Et      Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                       Me           Et      Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                       Me           Et      Gb                                        CHF.sub.2 OCH.sub.2                                                                            Me           Et      Gb                                        MeSCH.sub.2     Me           Et      Ga                                        EtSCH.sub.2     Me           Et      Ga                                        MeSCH.sub.2 CH.sub.2                                                                           Me           Et      Gb                                        EtSCH.sub.2 CH.sub.2                                                                           Me           Et      Ga                                        MeSO.sub.2 CH.sub.2                                                                            Me           Et      Gb                                        EtSO.sub.2 CH.sub.2                                                                            Me           Et      Ga                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                                   Me           Et      Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                                   Me           Et      Gb                                        FCH.sub.2       Me           Et      Ga                                        ClCH.sub.2      Me           Et      Ga                                        BrCH.sub.2      Me           Et      Ga                                        ICH.sub.2       Me           Et      Ga                                        FCH.sub.2 CH.sub.2                                                                             Me           Et      Ga                                        ClCH.sub.2 CH.sub.2                                                                            Me           Et      Ga                                        BrCH.sub.2 CH.sub.2                                                                            Me           Et      Ga                                        ICH.sub.2 CH.sub.2                                                                             Me           Et      Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                         Me           Et      Gb                                        ClCH.sub.2 (CH.sub.3)CH                                                                        Me           Et      Gb                                        BrCH.sub.2 (CH.sub.3)CH                                                                        Me           Et      Gb                                        ICH.sub.2 (CH.sub.3)CH                                                                         Me           Et      Gb                                        CF.sub.3 CH.sub.2                                                                              Me           Et      Ga                                        NCCH.sub.2      Me           Et      Ga                                        NCCH.sub.2 CH.sub.2                                                                            Me           Et      Ga                                        MeO.sub.2 CCH.sub.2                                                                            Me           Et      Ga                                        EtO.sub.2 CCH.sub.2                                                                            Me           Et      Gb                                        Pr-nO.sub.2 CCH.sub.2                                                                          Me           Et      Gc                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                                   Me           Et      Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                                   Me           Et      Gb                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                                 Me           Et      Gc                                        MeCOCH.sub.2    Me           Et      Ga                                        PhCH.sub.2      Me           Et      Ga                                        Ph              Me           Et      Ga                                        H               Me           Pr-n    Ga                                        Me              Me           Pr-n    Ga                                        Et              Me           Pr-n    Ga                                        Pr-n            Me           Pr-n    Gb                                        Pr-i            Me           Pr-n    Gb                                        cyc-Pr          Me           Pr-n    Gb                                        CH.sub.2CHCH.sub.2                                                                             Me           Pr-n    Ga                                        CHCCH.sub.2     Me           Pr-n    Ga                                        MeOCH.sub.2     Me           Pr-n    Ga                                        MeOCH.sub.2 CH.sub.2                                                                           Me           Pr-n    Ga                                        CHF.sub.2 OCH.sub.2                                                                            Me           Pr-n    Ga                                        MeSCH.sub.2     Me           Pr-n    Ga                                        MeSCH.sub.2 CH.sub.2                                                                           Me           Pr-n    Ga                                        MeSO.sub.2 CH.sub.2                                                                            Me           Pr-n    Ga                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                                   Me           Pr-n    Ga                                        FCH.sub.2       Me           Pr-n    Ga                                        ClCH.sub.2      Me           Pr-n    Ga                                        BrCH.sub.2      Me           Pr-n    Ga                                        ICH.sub.2       Me           Pr-n    Ga                                        FCH.sub.2 CH.sub.2                                                                             Me           Pr-n    Ga                                        ClCH.sub.2 CH.sub.2                                                                            Me           Pr-n    Ga                                        BrCH.sub.2 CH.sub.2                                                                            Me           Pr-n    Ga                                        ICH.sub.2 CH.sub.2                                                                             Me           Pr-n    Ga                                        CF.sub.3 CH.sub.2                                                                              Me           Pr-n    Ga                                        NCCH.sub.2      Me           Pr-n    Ga                                        NCCH.sub.2 CH.sub.2                                                                            Me           Pr-n    Ga                                        MeO.sub.2 CCH.sub.2                                                                            Me           Pr-n    Ga                                        MeCOCH.sub.2    Me           Pr-n    Ga                                        PhCH.sub.2      Me           Pr-n    Ga                                        Ph              Me           Pr-n    Ga                                        H               Et           Me      Ga                                        Me              Et           Me      Ga                                        Et              Et           Me      Ga                                        Pr-n            Et           Me      Gb                                        Pr-i            Et           Me      Gb                                        cyc-Pr          Et           Me      Gb                                        cyc-PrCH.sub.2  Et           Me      Gb                                        Bu-n            Et           Me      Gb                                        Bu-sec          Et           Me      Gb                                        Bu-t            Et           Me      Gb                                        CH.sub.2CHCH.sub.2                                                                             Et           Me      Ga                                        CHCCH.sub.2     Et           Me      Ga                                        MeOCH.sub.2     Et           Me      Ga                                        EtOCH.sub.2     Et           Me      Gb                                        MeOCH.sub.2 CH.sub.2                                                                           Et           Me      Ga                                        EtOCH.sub.2 CH.sub.2                                                                           Et           Me      Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                       Et           Me      Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                       Et           Me      Gb                                        CHF.sub.2 OCH.sub.2                                                                            Et           Me      Ga                                        MeSCH.sub.2     Et           Me      Ga                                        EtSCH.sub.2     Et           Me      Gb                                        MeSCH.sub.2 CH.sub.2                                                                           Et           Me      Ga                                        EtSCH.sub.2 CH.sub.2                                                                           Et           Me      Gb                                        MeSO.sub.2 CH.sub.2                                                                            Et           Me      Ga                                        EtSO.sub.2 CH.sub.2                                                                            Et           Me      Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                                   Et           Me      Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                                   Et           Me      Ga                                        FCH.sub.2       Et           Me      Ga                                        ClCH.sub.2      Et           Me      Ga                                        BrCH.sub.2      Et           Me      Ga                                        ICH.sub.2       Et           Me      Ga                                        FCH.sub.2 CH.sub.2                                                                             Et           Me      Ga                                        ClCH.sub.2 CH.sub.2                                                                            Et           Me      Ga                                        BrCH.sub.2 CH.sub.2                                                                            Et           Me      Ga                                        ICH.sub.2 CH.sub.2                                                                             Et           Me      Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                         Et           Me      Gb                                        ClCH.sub.2 (CH.sub.3)CH                                                                        Et           Me      Gb                                        BrCH.sub.2 (CH.sub.3)CH                                                                        Et           Me      Gb                                        ICH.sub.2 (CH.sub.3)CH                                                                         Et           Me      Gb                                        CF.sub.3 CH.sub.2                                                                              Et           Me      Ga                                        NCCH.sub.2      Et           Me      Ga                                        NCCH.sub.2 CH.sub.2                                                                            Et           Me      Ga                                        MeO.sub.2 CCH.sub.2                                                                            Et           Me      Ga                                        EtO.sub.2 CCH.sub.2                                                                            Et           Me      Gb                                        Pr-nO.sub.2 CCH.sub.2                                                                          Et           Me      Gc                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                                   Et           Me      Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                                   Et           Me      Gb                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                                 Et           Me      Gc                                        MeCOCH.sub.2    Et           Me      Ga                                        PhCH.sub.2      Et           Me      Ga                                        Ph              Et           Me      Ga                                        H               Pr-n         Me      Ga                                        Me              Pr-n         Me      Ga                                        Et              Pr-n         Me      Ga                                        Pr-n            Pr-n         Me      Gb                                        Pr-i            Pr-n         Me      Gb                                        cyc-Pr          Pr-n         Me      Gb                                        CH.sub.2CHCH.sub.2                                                                             Pr-n         Me      Ga                                        CHCCH.sub.2     Pr-n         Me      Ga                                        MeOCH.sub.2     Pr-n         Me      Ga                                        MeSCH.sub.2     Pr-n         Me      Ga                                        MeSCH.sub.2 CH.sub.2                                                                           Pr-n         Me      Ga                                        MeSO.sub.2 CH.sub.2                                                                            Pr-n         Me      Ga                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                                   Pr-n         Me      Ga                                        FCH.sub.2       Pr-n         Me      Ga                                        ClCH.sub.2      Pr-n         Me      Ga                                        BrCH.sub.2      Pr-n         Me      Ga                                        ICH.sub.2       Pr-n         Me      Ga                                        FCH.sub.2 CH.sub.2                                                                             Pr-n         Me      Ga                                        ClCH.sub.2 CH.sub.2                                                                            Pr-n         Me      Ga                                        BrCH.sub.2 CH.sub.2                                                                            Pr-n         Me      Ga                                        ICH.sub.2 CH.sub.2                                                                             Pr-n         Me      Ga                                        CF.sub.3 CH.sub.2                                                                              Pr-n         Me      Ga                                        NCCH.sub.2      Pr-n         Me      Ga                                        NCCH.sub.2 CH.sub.2                                                                            Pr-n         Me      Ga                                        MeO.sub.2 CCH.sub.2                                                                            Pr-n         Me      Ga                                        MeCOCH.sub.2    Pr-n         Me      Ga                                        PhCH.sub.2      Pr-n         Me      Ga                                        Ph              Pr-n         Me      Ga                                        H               Et           Et      Ga                                        Me              Et           Et      Ga                                        Et              Et           Et      Ga                                        Pr-n            Et           Et      Gb                                        Pr-i            Et           Et      Gb                                        cyc-Pr          Et           Et      Gb                                        CH.sub.2CHCH.sub.2                                                                             Et           Et      Ga                                        CHCCH.sub.2     Et           Et      Ga                                        MeOCH.sub.2     Et           Et      Ga                                        MeOCH.sub.2 CH.sub.2                                                                           Et           Et      Ga                                        MeSCH.sub.2     Et           Et      Ga                                        MeSCH.sub.2 CH.sub.2                                                                           Et           Et      Ga                                        MeSO.sub.2 CH.sub.2                                                                            Et           Et      Ga                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                                   Et           Et      Ga                                        FCH.sub.2       Et           Et      Ga                                        ClCH.sub.2      Et           Et      Ga                                        BrCH.sub.2      Et           Et      Ga                                        ICH.sub.2       Et           Et      Ga                                        FCH.sub.2 CH.sub.2                                                                             Et           Et      Ga                                        ClCH.sub.2 CH.sub.2                                                                            Et           Et      Ga                                        BrCH.sub.2 CH.sub.2                                                                            Et           Et      Ga                                        ICH.sub.2 CH.sub.2                                                                             Et           Et      Ga                                        CF.sub.3 CH.sub.2                                                                              Et           Et      Ga                                        NCCH.sub.2      Et           Et      Ga                                        NCCH.sub.2 CH.sub.2                                                                            Et           Et      Ga                                        MeO.sub.2 CCH.sub.2                                                                            Et           Et      Ga                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                                   Et           Et      Ga                                        MeCOCH.sub.2    Et           Et      Ga                                        PhCH.sub.2      Et           Et      Ga                                        Ph              Et           Et      Ga                                        H               CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        Me              CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        Et              CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        Pr-n            CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        Pr-i            CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        cyc-Pr          CH.sub.2 CHCH.sub.2                                                                         Me      Gb                                        cyc-PrCH.sub.2  CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        Bu-n            CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        Bu-sec          CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        Bu-t            CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        CH.sub.2CHCH.sub.2                                                                             CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        CHCCH.sub.2     CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        MeOCH.sub.2     CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        EtOCH.sub.2     CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        MeOCH.sub.2 CH.sub.2                                                                           CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        EtOCH.sub.2 CH.sub.2                                                                           CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                       CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                       CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        CHF.sub.2 OCH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        MeSCH.sub.2     CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        EtSCH.sub.2     CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        MeSCH.sub.2 CH.sub.2                                                                           CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        EtSCH.sub.2 CH.sub.2                                                                           CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        MeSO.sub.2 CH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        EtSO.sub.2 CH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                                   CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        EtSO.sub.2 CH.sub. 2 CH.sub.2                                                                  CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        FCH.sub.2       CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        ClCH.sub.2      CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        BrCH.sub.2      CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        ICH.sub.2       CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        FCH.sub.2 CH.sub.2                                                                             CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        ClCH.sub.2 CH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        BrCH.sub.2 CH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        ICH.sub.2 CH.sub.2                                                                             CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                         CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        ClCH.sub.2 (CH.sub.3)CH                                                                        CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        BrCH.sub.2 (CH.sub.3)CH                                                                        CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        ICH.sub.2 (CH.sub.3)CH                                                                         CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        CF.sub.3 CH.sub.2                                                                              CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        NCCH.sub.2      CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        NCCH.sub.2 CH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        MeO.sub.2 CCH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        EtO.sub.2 CCH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        Pr-nO.sub.2 CCH.sub.2                                                                          CH.sub.2CHCH.sub.2                                                                          Me      Gc                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                                   CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        EtO.sub.2 CCH.sub.2 CH.sub. 2                                                                  CH.sub.2CHCH.sub.2                                                                          Me      Gb                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                                 CH.sub.2CHCH.sub.2                                                                          Me      Gc                                        MeCOCH.sub.2    CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        PhCH.sub.2      CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        Ph              CH.sub.2CHCH.sub.2                                                                          Me      Ga                                        H               CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        Me              CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        Et              CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        Pr-n            CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        Pr-i            CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        cyc-Pr          CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        cyc-PrCH.sub.2  CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        Bu-n            CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        Bu-sec          CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        Bu-t            CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        CH.sub.2CHCH.sub.2                                                                             CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        CHCCH.sub.2     CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        MeOCH.sub.2     CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        EtOCH.sub.2     CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        MeOCH.sub.2 CH.sub.2                                                                           CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        EtOCH.sub.2 CH.sub.2                                                                           CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                       CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                       CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        CHF.sub.2 OCH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        MeSCH.sub.2     CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        EtSCH.sub.2     CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        MeSCH.sub.2 CH.sub.2                                                                           CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        EtSCH.sub.2 CH.sub.2                                                                           CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        MeSO.sub.2 CH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        EtSO.sub.2 CH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                                   CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                                   CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        FCH.sub.2       CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        ClCH.sub.2      CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        BrCH.sub.2      CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        ICH.sub.2       CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        FCH.sub.2 CH.sub.2                                                                             CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        ClCH.sub.2 CH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        BrCH.sub.2 CH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        ICH.sub.2 CH.sub.2                                                                             CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                         CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        ClCH.sub.2 (CH.sub.3)CH                                                                        CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        BrCH.sub.2 (CH.sub.3)CH                                                                        CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        ICH.sub.2 (CH.sub.3)CH                                                                         CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        CF.sub.3 CH.sub.2                                                                              CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        NCCH.sub.2      CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        NCCH.sub.2 CH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        MeO.sub.2 CCH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        EtO.sub.2 CCH.sub.2                                                                            CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        Pr-nO.sub.2 CCH.sub.2                                                                          CH.sub.2CHCH.sub.2                                                                          Et      Gc                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                                   CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                                   CH.sub.2CHCH.sub.2                                                                          Et      Gb                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                                 CH.sub.2CHCH.sub.2                                                                          Et      Gc                                        MeCOCH.sub.2    CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        PhCH.sub.2      CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        Ph              CH.sub.2CHCH.sub.2                                                                          Et      Ga                                        H               Ph           Me      Ga                                        Me              Ph           Me      Ga                                        Et              Ph           Me      Ga                                        Pr-n            Ph           Me      Gb                                        Pr-i            Ph           Me      Gb                                        cyc-Pr          Ph           Me      Gb                                        cyc-PrCH.sub.2  Ph           Me      Gb                                        Bu-n            Ph           Me      Gb                                        Bu-sec          Ph           Me      Gb                                        Bu-t            Ph           Me      Gb                                        CH.sub.2CHCH.sub.2                                                                             Ph           Me      Ga                                        CHCCH.sub.2     Ph           Me      Ga                                        MeOCH.sub.2     Ph           Me      Ga                                        EtOCH.sub.2     Ph           Me      Gb                                        MeOCH.sub.2 CH.sub. 2                                                                          Ph           Me      Ga                                        EtOCH.sub.2 CH.sub.2                                                                           Ph           Me      Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                       Ph           Me      Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                       Ph           Me      Gb                                        CHF.sub.2 OCH.sub.2                                                                            Ph           Me      Ga                                        MeSCH.sub.2     Ph           Me      Ga                                        EtSCH.sub.2     Ph           Me      Gb                                        MeSCH.sub.2 CH.sub.2                                                                           Ph           Me      Ga                                        EtSCH.sub.2 CH.sub.2                                                                           Ph           Me      Gb                                        MeSO.sub.2 CH.sub.2                                                                            Ph           Me      Ga                                        EtSO.sub.2 CH.sub.2                                                                            Ph           Me      Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                                   Ph           Me      Gb                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                                   Ph           Me      Ga                                        FCH.sub.2       Ph           Me      Ga                                        ClCH.sub.2      Ph           Me      Ga                                        BrCH.sub.2      Ph           Me      Ga                                        ICH.sub.2       Ph           Me      Ga                                        FCH.sub.2 CH.sub.2                                                                             Ph           Me      Ga                                        ClCH.sub.2 CH.sub.2                                                                            Ph           Me      Ga                                        BrCH.sub.2 CH.sub.2                                                                            Ph           Me      Ga                                        ICH.sub.2 CH.sub.2                                                                             Ph           Me      Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                         Ph           Me      Gb                                        ClCH.sub.2 (CH.sub.3)CH                                                                        Ph           Me      Gb                                        BrCH.sub.2 (CH.sub.3)CH                                                                        Ph           Me      Gb                                        ICH.sub.2 (CH.sub.3)CH                                                                         Ph           Me      Gb                                        CF.sub.3 CH.sub.2                                                                              Ph           Me      Ga                                        NCCH.sub.2      Ph           Me      Ga                                        NCCH.sub.2 CH.sub.2                                                                            Ph           Me      Ga                                        MeO.sub.2 CCH.sub.2                                                                            Ph           Me      Ga                                        EtO.sub.2 CCH.sub.2                                                                            Ph           Me      Gb                                        Pr-nO.sub.2 CCH.sub.2                                                                          Ph           Me      Gc                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                                   Ph           Me      Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                                   Ph           Me      Gb                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                                 Ph           Me      Gc                                        MeCOCH.sub.2    Ph           Me      Ga                                        PhCH.sub.2      Ph           Me      Ga                                        Ph              Ph           Me      Ga                                        H               Ph           Et      Ga                                        Me              Ph           Et      Ga                                        Et              Ph           Et      Ga                                        Pr-n            Ph           Et      Gb                                        Pr-i            Ph           Et      Gb                                        cyc-Pr          Ph           Et      Gb                                        cyc-PrCH.sub.2  Ph           Et      Gb                                        Bu-n            Ph           Et      Gb                                        Bu-sec          Ph           Et      Gb                                        Bu-t            Ph           Et      Gb                                        CH.sub.2CHCH.sub.2                                                                             Ph           Et      Ga                                        CHCCH.sub.2     Ph           Et      Ga                                        MeOCH.sub.2     Ph           Et      Ga                                        EtOCH.sub.2     Ph           Et      Gb                                        MeOCH.sub.2 CH.sub.2                                                                           Ph           Et      Ga                                        EtOCH.sub.2 CH.sub.2                                                                           Ph           Et      Gb                                        MeOCH.sub.2 (CH.sub.3)CH                                                                       Ph           Et      Gb                                        EtOCH.sub.2 (CH.sub.3)CH                                                                       Ph           Et      Gb                                        CHF.sub.2 OCH.sub.2                                                                            Ph           Et      Ga                                        MeSCH.sub.2     Ph           Et      Ga                                        EtSCH.sub.2     Ph           Et      Gb                                        MeSCH.sub.2 CH.sub.2                                                                           Ph           Et      Ga                                        EtSCH.sub.2 CH.sub.2                                                                           Ph           Et      Gb                                        MeSO.sub.2 CH.sub.2                                                                            Ph           Et      Ga                                        EtSO.sub.2 CH.sub.2                                                                            Ph           Et      Gb                                        MeSO.sub.2 CH.sub.2 CH.sub.2                                                                   Ph           Et      Ga                                        EtSO.sub.2 CH.sub.2 CH.sub.2                                                                   Ph           Et      Gb                                        FCH.sub.2       Ph           Et      Ga                                        ClCH.sub.2      Ph           Et      Ga                                        BrCH.sub.2      Ph           Et      Ga                                        ICH.sub.2       Ph           Et      Ga                                        FCH.sub.2 CH.sub.2                                                                             Ph           Et      Ga                                        ClCH.sub.2 CH.sub.2                                                                            Ph           Et      Ga                                        BrCH.sub.2 CH.sub.2                                                                            Ph           Et      Ga                                        ICH.sub.2 CH.sub.2                                                                             Ph           Et      Ga                                        FCH.sub.2 (CH.sub.3)CH                                                                         Ph           Et      Gb                                        ClCH.sub.2 (CH.sub.3)CH                                                                        Ph           Et      Gb                                        BrCH.sub.2 (CH.sub.3)CH                                                                        Ph           Et      Gb                                        ICH.sub.2 (CH.sub.3)CH                                                                         Ph           Et      Gb                                        CF.sub.3 CF.sub.2                                                                              Ph           Et      Ga                                        NCCH.sub.2      Ph           Et      Ga                                        NCCH.sub.2 CH.sub.2                                                                            Ph           Et      Ga                                        MeO.sub.2 CCH.sub.2                                                                            Ph           Et      Ga                                        EtO.sub.2 CCH.sub.2                                                                            Ph           Et      Gb                                        Pr-nO.sub.2 CCH.sub.2                                                                          Ph           Et      Gc                                        MeO.sub.2 CCH.sub.2 CH.sub.2                                                                   Ph           Et      Ga                                        EtO.sub.2 CCH.sub.2 CH.sub.2                                                                   Ph           Et      Gb                                        Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                                 Ph           Et      Gc                                        MeCOCH.sub.2    Ph           Et      Ga                                        PhCH.sub.2      Ph           Et      Ga                                        Ph              Ph           Et      Ga                                        H                  (CH.sub.2).sub.3                                                                             Ga                                            Me                 (CH.sub.2).sub.3                                                                             Ga                                            Et                  (CH.sub.2).sub.3                                                                            Ga                                            Pr-n               (CH.sub.2).sub.3                                                                             Gb                                            Pr-i               (CH.sub.2).sub.3                                                                             Gb                                            cyc-Pr             (CH.sub.2).sub.3                                                                             Gb                                            cyc-PrCH.sub.2     (CH.sub.2).sub.3                                                                             Gb                                            Bu-n               (CH.sub.2).sub.3                                                                             Gb                                            Bu-sec             (CH.sub.2).sub.3                                                                             Gb                                            Bu-t               (CH.sub.2).sub.3                                                                             Gb                                            CH.sub.2CHCH.sub.2 (CH.sub.2).sub.3                                                                             Ga                                            CHCCH.sub.2        (CH.sub.2).sub.3                                                                             Ga                                            MeOCH.sub.2        (CH.sub.2).sub.3                                                                             Ga                                            EtOCH.sub.2        (CH.sub.2).sub.3                                                                             Gb                                            MeOCH.sub.2 CH.sub.2                                                                              (CH.sub.2).sub.3                                                                             Ga                                            EtOCH.sub.2 CH.sub.2                                                                              (CH.sub.2).sub.3                                                                             Gb                                            MeOCH.sub.2 (CH.sub.3)CH                                                                          (CH.sub.2).sub.3                                                                             Gb                                            EtOCH.sub.2 (CH.sub.3)CH                                                                          (CH.sub.2).sub.3                                                                             Gb                                            CHF.sub.2 OCH.sub.2                                                                               (CH.sub.2).sub.3                                                                             Ga                                            MeSCH.sub.2        (CH.sub.2).sub.3                                                                             Ga                                            EtSCH.sub.2        (CH.sub.2).sub.3                                                                             Gb                                            MeSCH.sub.2 CH.sub.2                                                                              (CH.sub.2).sub.3                                                                             Ga                                            EtSCH.sub.2 CH.sub.2                                                                              (CH.sub.2).sub.3                                                                             Gb                                            MeSO.sub.2 CH.sub.2                                                                               (CH.sub.2).sub.3                                                                             Ga                                            EtSO.sub.2 CH.sub.2                                                                               (CH.sub.2).sub.3                                                                             Gb                                            MeSO.sub.2 CH.sub.2 CH.sub.2                                                                      (CH.sub.2).sub.3                                                                             Gb                                            EtSO.sub.2 CH.sub.2 CH.sub.2                                                                      (CH.sub.2).sub.3                                                                             Ga                                            FCH.sub.2          (CH.sub.2).sub.3                                                                             Ga                                            ClCH.sub.2         (CH.sub.2).sub.3                                                                             Ga                                            BrCH.sub.2         (CH.sub.2).sub.3                                                                             Ga                                            ICH.sub.2          (CH.sub.2).sub.3                                                                             Ga                                            FCH.sub.2 CH.sub.2 (CH.sub.2).sub.3                                                                             Ga                                            ClCH.sub.2 CH.sub.2                                                                               (CH.sub.2).sub.3                                                                             Ga                                            BrCH.sub.2 CH.sub.2                                                                               (CH.sub.2).sub.3                                                                             Ga                                            ICH.sub.2 CH.sub.2 (CH.sub.2).sub.3                                                                             Ga                                            FCH.sub.2 (CH.sub.3)CH                                                                            (CH.sub.2).sub.3                                                                             Gb                                            ClCH.sub.2 (CH.sub.3)CH                                                                           (CH.sub.2).sub.3                                                                             Gb                                            BrCH.sub.2 (CH.sub.3)CH                                                                           (CH.sub.2).sub.3                                                                             Gb                                            ICH.sub.2 (CH.sub.3)CH                                                                            (CH.sub.2).sub.3                                                                             Gb                                            CF.sub.3 CH.sub.2  (CH.sub.2).sub.3                                                                             Ga                                            NCCH.sub.2         (CH.sub. 2).sub.3                                                                            Ga                                            NCCH.sub.2 CH.sub.2                                                                               (CH.sub.2).sub.3                                                                             Ga                                            MeO.sub.2 CCH.sub.2                                                                               (CH.sub.2).sub.3                                                                             Ga                                            EtO.sub.2 CCH.sub.2                                                                               (CH.sub.2).sub.3                                                                             Gb                                            Pr-nO.sub.2 CCH.sub.2                                                                             (CH.sub.2).sub.3                                                                             Gc                                            MeO.sub.2 CCH.sub.2 CH.sub.2                                                                      (CH.sub.2).sub.3                                                                             Ga                                            EtO.sub.2 CCH.sub.2 CH.sub.2                                                                      (CH.sub.2).sub.3                                                                             Gb                                            Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                                    (CH.sub.2).sub.3                                                                             Gc                                            MeCOCH.sub.2       (CH.sub.2).sub.3                                                                             Ga                                            PhCH.sub.2         (CH.sub.2).sub.3                                                                             Ga                                            Ph                 (CH.sub.2).sub.3                                                                             Ga                                            H                  (CH.sub.2).sub.4                                                                             Ga                                            Me                 (CH.sub.2).sub.4                                                                             Ga                                            Et                 (CH.sub.2).sub.4                                                                             Ga                                            Pr-n               (CH.sub.2).sub.4                                                                             Gb                                            Pr-i               (CH.sub.2).sub.4                                                                             Gb                                            cyc-Pr             (CH.sub.2).sub.4                                                                             Gb                                            cyc-PrCH.sub.2     (CH.sub.2).sub.4                                                                             Gb                                            Bu-n               (CH.sub.2).sub.4                                                                             Gb                                            Bu-sec             (CH.sub.2).sub.4                                                                             Gb                                            Bu-t               (CH.sub.2).sub.4                                                                             Gb                                            CH.sub.2CHCH.sub.2 (CH.sub.2).sub.4                                                                             Ga                                            CHCCH.sub.2        (CH.sub.2).sub.4                                                                             Ga                                            MeOCH.sub.2        (CH.sub.2).sub.4                                                                             Ga                                            EtOCH.sub.2        (CH.sub.2).sub.4                                                                             Gb                                            MeOCH.sub.2 CH.sub.2                                                                              (CH.sub.2).sub.4                                                                             Ga                                            EtOCH.sub.2 CH.sub.2                                                                              (CH.sub.2).sub.4                                                                             Gb                                            MeOCH.sub.2 (CH.sub.3)CH                                                                          (CH.sub.2).sub.4                                                                             Gb                                            EtOCH.sub.2 (CH.sub.3)CH                                                                          (CH.sub.2).sub.4                                                                             Gb                                            CHF.sub.2 OCH.sub.2                                                                               (CH.sub.2).sub.4                                                                             Ga                                            MeSCH.sub.2        (CH.sub.2).sub.4                                                                             Ga                                            EtSCH.sub.2        (CH.sub.2).sub.4                                                                             Gb                                            MeSCH.sub.2 CH.sub.2                                                                              (CH.sub.2).sub.4                                                                             Ga                                            EtSCH.sub.2 CH.sub.2                                                                              (CH.sub.2).sub.4                                                                             Gb                                            MeSO.sub.2 CH.sub.2                                                                               (CH.sub.2).sub.4                                                                             Ga                                            EtSO.sub.2 CH.sub.2                                                                               (CH.sub.2).sub.4                                                                             Gb                                            MeSO.sub.2 CH.sub.2 CH.sub.2                                                                      (CH.sub.2).sub.4                                                                             Ga                                            EtSO.sub.2 CH.sub.2 CH.sub.2                                                                      (CH.sub.2).sub.4                                                                             Gb                                            FCH.sub.2          (CH.sub.2).sub.4                                                                             Ga                                            ClCH.sub.2         (CH.sub.2).sub.4                                                                             Ga                                            BrCH.sub.2         (CH.sub.2).sub.4                                                                             Ga                                            ICH.sub.2          (CH.sub.2).sub.4                                                                             Ga                                            FCH.sub.2 CH.sub.2 (CH.sub.2).sub.4                                                                             Ga                                            ClCH.sub.2 CH.sub.2                                                                               (CH.sub.2).sub.4                                                                             Ga                                            BrCH.sub.2 CH.sub.2                                                                               (CH.sub.2).sub.4                                                                             Ga                                            ICH.sub.2 CH.sub.2 (CH.sub.2).sub.4                                                                             Ga                                            FCH.sub.2 (CH.sub.3)CH                                                                            (CH.sub.2).sub.4                                                                             Gb                                            ClCH.sub.2 (CH.sub.3)CH                                                                           (CH.sub.2).sub.4                                                                             Gb                                            BrCH.sub.2 (CH.sub.3)CH                                                                           (CH.sub.2).sub.4                                                                             Gb                                            ICH.sub.2 (CH.sub.3)CH                                                                            (CH.sub.2).sub.4                                                                             Gb                                            CF.sub.3 CH.sub.2  (CH.sub.2).sub.4                                                                             Ga                                            NCCH.sub.2         (CH.sub.2).sub.4                                                                             Ga                                            NCCH.sub.2 CH.sub.2                                                                               (CH.sub.2).sub.4                                                                             Ga                                            MeO.sub.2 CCH.sub.2                                                                               (CH.sub.2).sub.4                                                                             Ga                                            EtO.sub.2 CCH.sub.2                                                                               (CH.sub.2).sub.4                                                                             Gb                                            Pr-nO.sub.2 CCH.sub.2                                                                             (CH.sub.2).sub.4                                                                             Gc                                            MeO.sub.2 CCH.sub.2 CH.sub.2                                                                      (CH.sub.2).sub.4                                                                             Ga                                            EtO.sub.2 CCH.sub.2 CH.sub.2                                                                      (CH.sub.2).sub.4                                                                             Gb                                            Pr-nO.sub.2 CCH.sub.2 CH.sub.2                                                                    (CH.sub.2).sub.4                                                                             Gc                                            MeCOCH.sub.2       (CH.sub.2).sub.4                                                                             Ga                                            PhCH.sub.2         (CH.sub.2).sub.4                                                                             Ga                                            Ph                 (CH.sub.2).sub.4                                                                             Ga                                            ______________________________________                                    

                  TABLE 4                                                          ______________________________________                                          ##STR147##                                                                    R.sup.11     R.sup.12    R.sup.13                                                                               Gn                                            ______________________________________                                         Me           Me          Me      Gb                                            Me           Me          Et      Gc                                            Me           Et          Et      Gb                                            Me           Me          Ph      Gc                                            Me           (CH.sub.2).sub.4                                                                               Gb                                                Me           (CH.sub.2).sub.5                                                                               Gb                                                Et           Me          Me      Gb                                            Et           Me          Et      Gc                                            Et           Et          Et      Gb                                            Et           Me          Ph      Gc                                            Et           (CH.sub.2).sub.4                                                                               Gb                                                Et           (CH.sub.2).sub.5                                                                               Gb                                                Pr-n         Me          Me      Gb                                            Pr-n         Me          Et      Gc                                            Pr-n         Et          Et      Gb                                            Pr-n         Me          Ph      Gc                                            Pr-n         (CH.sub.2).sub.4                                                                               Gb                                                Pr-n         (CH.sub.2).sub.5                                                                               Gb                                                CH.sub.2CHCH.sub.2                                                                          Me          Me      Gb                                            CH.sub.2CHCH.sub.2                                                                          Me          Et      Gc                                            CH.sub.2CHCH.sub.2                                                                          Et          Et      Gb                                            CH.sub.2CHCH.sub.2                                                                          Me          Ph      Gc                                            CH.sub.2CHCH.sub.2                                                                          (CH.sub.2 ).sub.4                                                                              Gb                                                CH.sub.2CHCH.sub.2                                                                          (CH.sub.2).sub.5                                                                               Gb                                                CHCCH.sub.2  Me          Me      Gb                                            CHCCH.sub.2  Me          Et      Gc                                            CHCCH.sub.2  Et          Et      Gb                                            CHCCH.sub.2  Me          Ph      Gc                                            CHCCH.sub.2  (CH.sub.2).sub.4                                                                               Gb                                                CHCCH.sub.2  (CH.sub.2).sub.5                                                                               Gb                                                MeOCH.sub.2 CH.sub.2                                                                        Me          Me      Gb                                            MeOCH.sub.2 CH.sub.2                                                                        Me          Et      Gc                                            MeOCH.sub.2 CH.sub.2                                                                        Et          Et      Gb                                            MeOCH.sub.2 CH.sub.2                                                                        Me          Ph      Gc                                            MeOCH.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.4                                                                               Gb                                                MeOCH.sub.2 CH.sub.2                                                                        (CH.sub.2).sub.5                                                                               Gb                                                ClCH.sub.2 CH.sub.2                                                                         Me          Me      Gb                                            ClCH.sub.2 CH.sub.2                                                                         Me          Et      Gc                                            ClCH.sub.2 CH.sub.2                                                                         Et          Et      Gb                                            ClCH.sub.2 CH.sub.2                                                                         Me          Ph      Gc                                            ClCH.sub.2 CH.sub.2                                                                         (CH.sub.2).sub.4                                                                               Gb                                                ClCH.sub.2 CH.sub.2                                                                         (CH.sub.2).sub.5                                                                               Gb                                                CF.sub.3 CH.sub.2                                                                           Me          Me      Gb                                            CF.sub.3 CH.sub.2                                                                           Me          Et      Gc                                            CF.sub.3 CH.sub.2                                                                           Et          Et      Gb                                            CF.sub.3 CH.sub.2                                                                           Me          Ph      Gc                                            CF.sub.3 CH.sub.2                                                                           (CH.sub.2).sub.4                                                                               Gb                                                CF.sub.3 CH.sub.2                                                                           (CH.sub.2).sub.5                                                                               Gb                                                NCCH.sub.2   Me          Me      Gb                                            NCCH.sub.2   Me          Et      Gc                                            NCCH.sub.2   Et          Et      Gb                                            NCCH.sub.2   Me          Ph      Gc                                            NCCH.sub.2   (CH.sub.2).sub.4                                                                               Gb                                                NCCH.sub.2   (CH.sub.2).sub.5                                                                               Gb                                                MeO.sub.2 CCH.sub.2                                                                         Me          Me      Gb                                            MeO.sub.2 CCH.sub.2                                                                         Me          Et      Gc                                            MeO.sub.2 CCH.sub.2                                                                         Et          Et      Gb                                            MeO.sub.2 CCH.sub.2                                                                         Me          Ph      Gc                                            MeO.sub.2 CCH.sub.2                                                                         (CH.sub.2).sub.4                                                                           Gb                                                    MeO.sub.2 CCH.sub.2                                                                         (CH.sub.2).sub.5                                                                           Gb                                                    PhCH.sub.2   Me           Me     Gb                                            PhCH.sub.2   Me          Et      Gc                                            PhCH.sub.2   Et          Et      Gb                                            PhCH.sub.2   Me          Ph      Gc                                            PhCH.sub.2   (CH.sub.2).sub.4                                                                               Gb                                                PhCH.sub.2   (CH.sub.2).sub.5                                                                               Gb                                                ______________________________________                                    

                  TABLE 5                                                          ______________________________________                                          ##STR148##                                                                    R.sup.11     R.sup.12    R.sup.13                                                                               Gn                                            ______________________________________                                         Me           Me          Me      Gb                                            Me           Me          Et      Gc                                            Me           Et          Et      Gb                                            Me           Me          Ph      Gc                                            Me           (CH.sub.2).sub.4                                                                               Gb                                                Me           (CH.sub.2).sub.5                                                                               Gb                                                Et           Me          Me      Gb                                            Et           Me          Et      Gc                                            Et           Et          Et      Gb                                            Et           Me          Ph      Gc                                            Et           (CH.sub.2).sub.4                                                                               Gb                                                Et           (CH.sub.2).sub.5                                                                               Gb                                                Pr-n         Me          Me      Gb                                            Pr-n         Me          Et      Gc                                            Pr-n         Et          Et      Gb                                            Pr-n         Me          Ph      Gc                                            Pr-n         (CH.sub.2).sub.4                                                                               Gb                                                Pr-n         (CH.sub.2).sub.5                                                                               Gb                                                CH.sub.2CHCH.sub.2                                                                          Me          Me      Gb                                            CH.sub.2CHCH.sub.2                                                                          Me          Et      Gc                                            CH.sub.2CHCH.sub.2                                                                          Et          Et      Gb                                            CH.sub.2CHCH.sub.2                                                                          Me          Ph      Gc                                            CH.sub.2CHCH.sub.2                                                                          (CH.sub. 2).sub.4                                                                              Gb                                                CH.sub.2CHCH.sub.2                                                                          (CH.sub.2).sub.5                                                                               Gb                                                ______________________________________                                    

                  TABLE 6                                                          ______________________________________                                          ##STR149##                                                                    R.sup.11    R.sup.12       R.sup.13                                                                              Gn                                           ______________________________________                                         Me          Me             Me     Gb                                           Et          Me             Me     Gb                                           cyc-Pr      Me             Me     Gb                                           CH.sub.2CHCH.sub.2                                                                         Me             Me     Gc                                           CHCCH.sub.2 Me             Me     Gc                                           MeOCH.sub.2 Me             Me     Gc                                           MeOCH.sub.2 CH.sub.2                                                                       Me             Me     Gc                                           MeSCH.sub.2 Me             Me     Gc                                           MeSO.sub.2 CH.sub.2                                                                        Me             Me     Gc                                           ClCH.sub.2 CH.sub.2                                                                        Me             Me     Gc                                           CF.sub.3 CH.sub.2                                                                          Me             Me     Gc                                           NCCH.sub.2 CH.sub.2                                                                        Me             Me     Gc                                           MeO.sub.2 CCH.sub.2                                                                        Me             Me     Gc                                           MeCOCH.sub.2                                                                               Me             Me     Gc                                           PhCH.sub.2  Me             Me     Gc                                           Ph          Me             Me     Gc                                           Me          Me             Et     Gb                                           Me          Me             Pr-n   Gb                                           Me          Et             Me     Gb                                           Me          Pr-n           Me     Gb                                           Me          Et             Et     Gb                                           Me          CH.sub.2CHCH.sub.2                                                                            Me     Gb                                           Me          CH.sub.2CHCH.sub.2                                                                            Et     Gb                                           Me          Ph             Me     Gb                                           Me          Ph             Et     Gb                                           Me          (CH.sub.2).sub.3  Gb                                               Me          (CH.sub.2).sub.4  Gb                                               ______________________________________                                    

                  TABLE 7                                                          ______________________________________                                          ##STR150##                                                                    R.sup.21    R.sup.22                                                                              R.sup.23                                                                              R.sup.24      Gn                                     ______________________________________                                         H           H      H      H             Ga                                     H           H      H      Me            Ga                                     H           H      H      Et            Gb                                     H           Me     H      H             Ga                                     H           Et     H      H             Gb                                     H           Me     H      Me            Gb                                     H           Me     H      Et            Gb                                     H           H      Me     Me            Ga                                     H           H      Me     Et            Gb                                     H           H      H      CF.sub.3      Ga                                     H           H      H      CH.sub.2 F    Ga                                     H           H      H      CH.sub.2 Cl   Ga                                     H           H      H      CH.sub.2 Br   Gb                                     H           H      H      CH.sub.2 I    Gb                                     H           H      H      CH.sub.2 OMe  Ga                                     H           H      H      CH.sub.2 OEt  Ga                                     H           H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     H           H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     H           H      H      CH.sub.2 OCHF.sub. 2                                                                         Ga                                     H           H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     H           H      H      CH.sub.2 SMe  Ga                                     H           H      H      CH.sub.2 SEt  Ga                                     H           H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     H           H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     H           H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     H           H      H      CH.sub.2 CN   Ga                                     H           H      H      CO.sub.2 Me   Ga                                     H           H      H      CO.sub.2 Et   Ga                                     H           H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     H           H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     H           H      H      COMe          Ga                                     H           H      H      COEt          Ga                                     H           H      H      CH.sub.2 COMe Ga                                     H           H      H      CH.sub.2 COEt Ga                                     Me          H      H      H             Ga                                     Me          H      H      Me            Ga                                     Me          H      H      Et            Gb                                     Me          H      H      Pr-n          Gb                                     Me          H      H      Pr-i          Gb                                     Me          H      H      Bu-n          Gc                                     Me          Me     H      H             Ga                                     Me          Et     H      H             Gb                                     Me          Me     H      Me            Gb                                     Me          Me     H      Et            Gb                                     Me          H      Me     Me            Ga                                     Me          H      Me     Et            Gb                                     Me          H      H      F             Ga                                     Me          H      H      Cl            Ga                                     Me          H      H      Br            Gb                                     Me          H      H      I             Gb                                     Me          H      H      CF.sub.3      Ga                                     Me          H      H      CH.sub.2 F    Ga                                     Me          H      H      CH.sub.2 Cl   Ga                                     Me          H      H      CH.sub.2 Br   Gb                                     Me          H      H      CH.sub.2 I    Gb                                     Me          H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     Me          H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     Me          H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     Me          H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     Me          H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     Me          H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     Me          H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     Me          H      H      CH(CH.sub.3 CH.sub.2 I                                                                       Gb                                     Me          H      H      CH.sub.2 OMe  Ga                                     Me          H      H      CH.sub.2 OEt  Ga                                     Me          H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     Me          H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     Me          H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     Me          H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     Me          H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     Me          H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     Me          H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     Me          H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     Me          H      H      CH.sub. 2 SMe Ga                                     Me          H      H      CH.sub.2 SEt  Ga                                     Me          H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     Me          H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     Me          H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     Me          H      H      CH.sub.2 CN   Ga                                     Me          H      H      CO.sub.2 Me   Ga                                     Me          H      H      CO.sub.2 Et   Ga                                     Me          H      H      CO.sub.2 Pr-n Gb                                     Me          H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     Me          H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     Me          H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     Me          H      H      COMe          Ga                                     Me          H      H      COEt          Ga                                     Me          H      H      COPr-n        Gb                                     Me          H      H      CH.sub.2 COMe Ga                                     Me          H      H      CH.sub.2 COEt Ga                                     Et          H      H      H             Ga                                     Et          H      H      Me            Ga                                     Et          H      H      Et            Gb                                     Et          H      H      Pr-n          Gb                                     Et          H      H      Pr-i          Gb                                     Et          H      H      Bu-n          Gc                                     Et          Me     H      H             Ga                                     Et          Et     H      H             Gb                                     Et          Me     H      Me            Gb                                     Et          Me     H      Et            Gb                                     Et          H      Me     Me            Ga                                     Et          H      Me     Et            Gb                                     Et          H      H      F             Ga                                     Et          H      H      Cl            Ga                                     Et          H      H      Br            Gb                                     Et          H      H      I             Gb                                     Et          H      H      CF.sub.3      Ga                                     Et          H      H      CH.sub.2 F    Ga                                     Et          H      H      CH.sub.2 Cl   Ga                                     Et          H      H      CH.sub.2 Br   Gb                                     Et          H      H      CH.sub.2 I    Gb                                     Et          H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     Et          H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     Et          H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     Et          H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     Et          H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     Et          H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     Et          H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     Et          H      H      CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     Et          H      H      CH.sub.2 OMe  Ga                                     Et          H      H      CH.sub.2 OEt  Ga                                     Et          H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     Et          H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     Et          H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     Et          H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     Et          H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     Et          H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     Et          H      H      CH.sub.2  OCHF.sub.2                                                                         Ga                                     Et          H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     Et          H      H      CH.sub.2 SMe  Ga                                     Et          H      H      CH.sub.2 SEt  Ga                                     Et          H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     Et          H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     Et          H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     Et          H      H      CH.sub.2 CN   Ga                                     Et          H      H      CO.sub.2 Me   Ga                                     Et          H      H      CO.sub.2 Et   Ga                                     Et          H      H      CO.sub.2 Pr-n Gb                                     Et          H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     Et          H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     Et          H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     Et          H      H      COMe          Ga                                     Et          H      H      COEt          Ga                                     Et          H      H      COPr-n        Gb                                     Et          H      H      CH.sub.2 COMe Ga                                     Et          H      H      CH.sub.2 COEt Ga                                     Pr-n        H      H      H             Ga                                     Pr-n        H      H      Me            Ga                                     Pr-n        H      H      Et            Gb                                     Pr-n        Me     H      H             Ga                                     Pr-n        Et     H      H             Gb                                     Pr-n        Me     H      Me            Gb                                     Pr-n        Me     H      Et            Gb                                     Pr-n        H      Me     Me            Ga                                     Pr-n        H      Me     Et            Gb                                     Pr-n        H      H      CF.sub.3      Ga                                     Pr-n        H      H      CH.sub.2 F    Ga                                     Pr-n        H      H      CH.sub.2 Cl   Ga                                     Pr-n        H      H      CH.sub.2 Br   Gb                                     Pr-n        H      H      CH.sub.2 I    Gb                                     Pr-n        H      H      CH.sub.2 OMe  Ga                                     Pr-n        H      H      CH.sub.2 OEt  Ga                                     Pr-n        H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     Pr-n        H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     Pr-n        H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     Pr-n        H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     Pr-n        H      H      CH.sub.2 SMe  Ga                                     Pr-n        H      H      CH.sub.2 SEt  Ga                                     Pr-n        H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     Pr-n        H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     Pr-n        H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     Pr-n        H      H      CH.sub.2 CN   Ga                                     Pr-n        H      H      CO.sub.2 Me   Ga                                     Pr-n        H      H      CO.sub.2 Et   Ga                                     Pr-n        H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     Pr-n        H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     Pr-n        H      H      COMe          Ga                                     Pr-n        H      H      COEt          Ga                                     Pr-n        H      H      CH.sub.2 COMe Ga                                     Pr-n        H      H      CH.sub.2 COEt Ga                                     Pr-i        H      H      H             Ga                                     Pr-i        H      H      Me            Ga                                     Pr-i        H      H      Et            Gb                                     Pr-i        Me     H      H             Ga                                     Pr-i        Et     H      H             Gb                                     Pr-i        Me     H      Me            Gb                                     Pr-i        Me     H      Et            Gb                                     Pr-i        H      Me     Me            Ga                                     Pr-i        H      Me     Et            Gb                                     Pr-i        H      H      CF.sub.3      Ga                                     Pr-i        H      H      CH.sub.2 F    Ga                                     Pr-i        H      H      CH.sub.2 Cl   Ga                                     Pr-i        H      H      CH.sub.2 Br   Gb                                     Pr-i        H      H      CH.sub.2 I    Gb                                     Pr-i        H      H      CH.sub.2 OMe  Ga                                     Pr-i        H      H      CH.sub.2 OEt  Ga                                     Pr-i        H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     Pr-i        H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     Pr-i        H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     Pr-i        H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     Pr-i        H      H      CH.sub.2 SMe  Ga                                     Pr-i        H      H      CH.sub.2 SEt  Ga                                     Pr-i        H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     Pr-i        H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     Pr-i        H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     Pr-i        H      H      CH.sub.2 CN   Ga                                     Pr-i        H      H      CO.sub.2 Me   Ga                                     Pr-i        H      H      CO.sub.2 Et   Ga                                     Pr-i        H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     Pr-i        H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     Pr-i        H      H      COMe          Ga                                     Pr-i        H      H      COEt          Ga                                     Pr-i        H      H      CH.sub.2 COMe Ga                                     Pr-i        H      H      CH.sub.2 COEt Ga                                     Bu-n        H      H      H             Ga                                     Bu-n        H      H      Me            Ga                                     Bu-n        Me     H      H             Ga                                     Bu-n        Me     H      Me            Gb                                     Bu-n        H      Me     Me            Ga                                     Bu-n        H      H      CF.sub.3      Ga                                     Bu-n        H      H      CH.sub.2 F    Ga                                     Bu-n        H      H      CH.sub.2 Cl   Ga                                     Bu-n        H      H      CH.sub.2 Br   Gb                                     Bu-n        H      H      CH.sub.2 I    Gb                                     Bu-n        H      H      CH.sub.2 OMe  Ga                                     Bu-n        H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     Bu-n        H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     Bu-n        H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     Bu-n        H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     Bu-n        H      H      CH.sub.2 SMe  Ga                                     Bu-n        H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     Bu-n        H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     Bu-n        H      H      CH.sub.2 CN   Ga                                     Bu-n        H      H      CO.sub.2 Me   Ga                                     Bu-n        H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     Bu-n        H      H      COMe          Ga                                     Bu-n        H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      H             Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      Me            Gb                                     CH.sub.2 CHCH.sub.2                                                                        H      H      Et            Gb                                     CH.sub.2 CHCH.sub.2                                                                        Me     H      H             Ga                                     CH.sub.2 CHCH.sub.2                                                                        Et     H      H             Gb                                     CH.sub.2 CHCH.sub.2                                                                        Me     H      Me            Gb                                     CH.sub.2 CHCH.sub.2                                                                        Me     H      Et            Gb                                     CH.sub.2 CHCH.sub.2                                                                        H      Me     Me            Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      Me     Et            Gb                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CF.sub.3      Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 F    Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 I    Gb                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub. 2 CHCH.sub.2                                                                       H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CO.sub.2 Et   Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      COMe          Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      COEt          Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CHCH.sub.2                                                                        H      H      CH.sub.2 COEt Ga                                     CH.sub.2 CCH                                                                               H      H      H             Ga                                     CH.sub.2 CCH                                                                               H      H      Me            Gb                                     CH.sub.2 CCH                                                                               H      H      Et            Gb                                     CH.sub.2 CCH                                                                               Me     H      H             Ga                                     CH.sub.2 CCH                                                                               Et     H      H             Gb                                     CH.sub.2 CCH                                                                               Me     H      Me            Gb                                     CH.sub.2 CCH                                                                               Me     H      Et            Gb                                     CH.sub.2 CCH                                                                               H      Me     Me            Ga                                     CH.sub.2 CCH                                                                               H      H      F             Ga                                     CH.sub.2 CCH                                                                               H      Me     Et            Gb                                     CH.sub.2 CCH                                                                               H      H      CF.sub.3      Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 F    Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 C CH                                                                              H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 I    Gb                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CCH                                                                               H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CCH                                                                               H      H      CO.sub.2 Et   Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CCH                                                                               H      H      COMe          Ga                                     CH.sub.2 CCH                                                                               H      H      COEt          Ga                                     CH.sub. 2 CCH                                                                              H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CCH                                                                               H      H      CH.sub.2 COEt Ga                                     CH.sub.2 OMe                                                                               H      H      H             Ga                                     CH.sub.2 OMe                                                                               H      H      Me            Gb                                     CH.sub.2 OMe                                                                               H      H      Et            Gb                                     CH.sub.2 OMe                                                                               H      H      Pr-n          Gb                                     CH.sub.2 OMe                                                                               H      H      Pr-i          Gb                                     CH.sub.2 OMe                                                                               H      H      Bu-n          Gc                                     CH.sub.2 OMe                                                                               Me     H      H             Ga                                     CH.sub.2 OMe                                                                               Et     H      H             Gb                                     CH.sub.2 OMe                                                                               Me     H      Me            Gb                                     CH.sub.2 OMe                                                                               Me     H      Et            Gb                                     CH.sub.2 OMe                                                                               H      Me     Me            Ga                                     CH.sub.2 OMe                                                                               H      Me     Et            Gb                                     CH.sub.2 OMe                                                                               H      H      F             Ga                                     CH.sub.2 OMe                                                                               H      H      Cl            Ga                                     CH.sub.2 OMe                                                                               H      H      Br            Gb                                     CH.sub.2 OMe                                                                               H      H      I             Gb                                     CH.sub.2 OMe                                                                               H      H      CF.sub.3      Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 F    Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 Br   Gb                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 I    Gb                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     CH.sub.2 OMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     CH.sub.2 OMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     CH.sub.2 OMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     CH.sub.2 OMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     CH.sub.2 OMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     CH.sub.2 OMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CN   Ga                                     CH.sub.2 OMe                                                                               H      H      CO.sub.2 Me   Ga                                     CH.sub.2 OMe                                                                               H      H      CO.sub.2 Et   Ga                                     CH.sub.2 OMe                                                                               H      H      CO.sub.2 Pr-n Gb                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     CH.sub.2 OMe                                                                               H      H      COMe          Ga                                     CH.sub.2 OMe                                                                               H      H      COEt          Ga                                     CH.sub.2 OMe                                                                               H      H      COPr-n        Gb                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 COMe Ga                                     CH.sub.2 OMe                                                                               H      H      CH.sub.2 COEt Ga                                     CH.sub.2 OEt                                                                               H      H      H             Ga                                     CH.sub.2 OEt                                                                               H      H      Me            Gb                                     CH.sub.2 OEt                                                                               H      H      Et            Gb                                     CH.sub.2 OEt                                                                               Me     H      H             Ga                                     CH.sub.2 OEt                                                                               Et     H      H             Gb                                     CH.sub.2 OEt                                                                               Me     H      Me            Gb                                     CH.sub.2 OEt                                                                               Me     H      Et            Gb                                     CH.sub.2 OEt                                                                               H      Me     Me            Ga                                     CH.sub.2 OEt                                                                               H      Me     Et            Gb                                     CH.sub.2 OEt                                                                               H      H      CF.sub.3      Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 F    Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 Br   Gb                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 I    Gb                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 CN   Ga                                     CH.sub.2 OEt                                                                               H      H      CO.sub.2 Me   Ga                                     CH.sub.2 OEt                                                                               H      H      CO.sub.2 Et   Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 OEt                                                                               H      H      COMe          Ga                                     CH.sub.2 OEt                                                                               H      H      COEt          Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 COMe Ga                                     CH.sub.2 OEt                                                                               H      H      CH.sub.2 COEt Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      H             Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      Me            Gb                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      Et            Gb                                     CH.sub.2 CH.sub.2 OMe                                                                      Me     H      H             Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      Et     H      H             Gb                                     CH.sub.2 CH.sub.2 OMe                                                                      Me     H      Me            Gb                                     CH.sub.2 CH.sub.2 OMe                                                                      Me     H      Et            Gb                                     CH.sub.2 CH.sub.2 OMe                                                                      H      Me     Me            Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      Me     Et            Gb                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CF.sub.3      Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 F    Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 I    Gb                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CO.sub.2 Et   Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      COMe          Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      COEt          Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CH.sub.2 OMe                                                                      H      H      CH.sub.2 COEt Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      H             Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      Me            Gb                                     CH.sub.2 CH.sub.2 OEt                                                                      Me     H      H             Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      Me     H      Me            Gb                                     CH.sub.2 CH.sub.2 OEt                                                                      H      Me     Me            Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CF.sub.3      Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 F    Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 I    Gb                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 OCH.sub.2 C CH                                                                      Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      COMe          Ga                                     CH.sub.2 CH.sub.2 OEt                                                                      H      H      CH.sub.2 COMe Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      H             Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      Et            Gb                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   Me     H      H             Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   Et     H      H             Gb                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   Me     H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   Me     H      Et            Gb                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      Me     Me            Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      Me     Et            Gb                                     CH(CH.sub.3 )CH.sub.2 OMe                                                                  H      H      CF.sub.3      Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 F    Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 Cl   Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 Br   Gb                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 I    Gb                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 OMe  Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 OEt  Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 SMe  Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 SEt  Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 CN   Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CO.sub.2 Me   Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CO.sub.2 Et   Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      COMe          Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      COEt          Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 COMe Ga                                     CH(CH.sub.3)CH.sub.2 OMe                                                                   H      H      CH.sub.2 COEt Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      H             Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   Me     H      H             Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   Me     H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      Me     Me            Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CF.sub.3      Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 F    Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 Cl   Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 Br   Gb                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 I    Gb                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 OMe  Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 SMe  Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 CN   Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CO.sub.2 Me   Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      COMe          Ga                                     CH(CH.sub.3)CH.sub.2 OEt                                                                   H      H      CH.sub.2 COMe Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      H             Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      Me            Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      Et            Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      Pr-n          Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      Pr-i          Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      Bu-n          Gc                                     CH.sub.2 OCHF.sub.2                                                                        Me     H      H             Ga                                     CH.sub.2 OCHF.sub.2                                                                        Et     H      H             Gb                                     CH.sub.2 OCHF.sub.2                                                                        Me     H      Me            Gb                                     CH.sub.2 OCHF.sub.2                                                                        Me     H      Et            Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      Me     Me            Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      Me     Et            Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      F             Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      Cl            Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      Br            Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      I             Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CF.sub.3      Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 F    Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 Br   Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 I    Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     CH.sub.2 OCHF.sub. 2                                                                       H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 SO.sub. 2 Et                                                                        Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CN   Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CO.sub.2 Me   Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CO.sub.2 Et   Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CO.sub.2 Pr-n Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      COMe          Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      COEt          Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      COPr-n        Gb                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 COMe Ga                                     CH.sub.2 OCHF.sub.2                                                                        H      H      CH.sub.2 COEt Ga                                     CH.sub.2 SMe                                                                               H      H      H             Ga                                     CH.sub.2 SMe                                                                               H      H      Me            Gb                                     CH.sub.2 SMe                                                                               H      H      Et            Gb                                     CH.sub.2 SMe                                                                               H      H      Pr-n          Gb                                     CH.sub.2 SMe                                                                               H      H      Pr-i          Gb                                     CH.sub.2 SMe                                                                               H      H      Bu-n          Gc                                     CH.sub.2 SMe                                                                               Me     H      H             Ga                                     CH.sub.2 SMe                                                                               Et     H      H             Gb                                     CH.sub.2 SMe                                                                               Me     H      Me            Gb                                     CH.sub.2 SMe                                                                               Me     H      Et            Gb                                     CH.sub.2 SMe                                                                               H      Me     Me            Ga                                     CH.sub.2 SMe                                                                               H      Me     Et            Gb                                     CH.sub.2 SMe                                                                               H      H      F             Ga                                     CH.sub.2 SMe                                                                               H      H      Cl            Ga                                     CH.sub.2 SMe                                                                               H      H      Br            Gb                                     CH.sub.2 SMe                                                                               H      H      I             Gb                                     CH.sub.2 SMe                                                                               H      H      CF.sub.3      Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 F    Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 Br   Gb                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 I    Gb                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     CH.sub.2 SMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     CH.sub.2 SMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     CH.sub.2 SMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     CH.sub.2 SMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     CH.sub.2 SMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     CH.sub.2 SMe                                                                               H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CN   Ga                                     CH.sub.2 SMe                                                                               H      H      CO.sub.2 Me   Ga                                     CH.sub.2 SMe                                                                               H      H      CO.sub.2 Et   Ga                                     CH.sub.2 SMe                                                                               H      H      CO.sub.2 Pr-n Gb                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     CH.sub.2 SMe                                                                               H      H      COMe          Ga                                     CH.sub.2 SMe                                                                               H      H      COEt          Ga                                     CH.sub.2 SMe                                                                               H      H      COPr-n        Gb                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 COMe Ga                                     CH.sub.2 SMe                                                                               H      H      CH.sub.2 COEt Ga                                     CH.sub.2 SEt                                                                               H      H      H             Ga                                     CH.sub.2 SEt                                                                               H      H      Me            Gb                                     CH.sub.2 SEt                                                                               H      H      Et            Gb                                     CH.sub.2 SEt                                                                               Me     H      H             Ga                                     CH.sub.2 SEt                                                                               Et     H      H             Gb                                     CH.sub.2 SEt                                                                               Me     H      Me            Gb                                     CH.sub.2 SEt                                                                               Me     H      Et            Gb                                     CH.sub.2 SEt                                                                               H      Me     Me            Ga                                     CH.sub.2 SEt                                                                               H      Me     Et            Gb                                     CH.sub.2 SEt                                                                               H      H      CF.sub.3      Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 F    Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 Br   Gb                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 I    Gb                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 OCH.sub.2 C CH                                                                      Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 CN   Ga                                     CH.sub.2 SEt                                                                               H      H      CO.sub.2 Me   Ga                                     CH.sub.2 SEt                                                                               H      H      CO.sub.2 Et   Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 SEt                                                                               H      H      COMe          Ga                                     CH.sub.2 SEt                                                                               H      H      COEt          Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 COMe Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 COEt Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 COMe Ga                                     CH.sub.2 SEt                                                                               H      H      CH.sub.2 COEt Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      H             Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      Me            Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      Et            Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      Pr-n          Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      Pr-i          Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      Bu-n          Gc                                     CH.sub.2 SO.sub.2 Me                                                                       Me     H      H             Ga                                     CH.sub.2 SO.sub.2 Me                                                                       Et     H      H             Gb                                     CH.sub.2 SO.sub.2 Me                                                                       Me     H      Me            Gb                                     CH.sub.2 SO.sub.2 Me                                                                       Me     H      Et            Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      Me     Me            Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      Me     Et            Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      F             Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      Cl            Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      Br            Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      I             Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CF.sub.3      Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 F    Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 Br   Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 I    Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub. 2 SO.sub.2 Me                                                                      H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CN   Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CO.sub.2 Me   Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CO.sub.2 Et   Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CO.sub.2 Pr-n Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      COMe          Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      COEt          Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      COPr-n        Gb                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 COMe Ga                                     CH.sub.2 SO.sub.2 Me                                                                       H      H      CH.sub.2 COEt Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      H             Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      Me            Gb                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      Et            Gb                                     CH.sub.2 SO.sub.2 Et                                                                       Me     H      H             Ga                                     CH.sub.2 SO.sub.2 Et                                                                       Et     H      H             Gb                                     CH.sub.2 SO.sub.2 Et                                                                       Me     H      Me            Gb                                     CH.sub.2 SO.sub.2 Et                                                                       Me     H      Et            Gb                                     CH.sub.2 SO.sub.2 Et                                                                       H      Me     Me            Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      Me     Et            Gb                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CF.sub.3      Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 F    Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 Br   Gb                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 I    Gb                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 CN   Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CO.sub.2 Me   Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CO.sub.2 Et   Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      COMe          Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      COEt          Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 COMe Ga                                     CH.sub.2 SO.sub.2 Et                                                                       H      H      CH.sub.2 COEt Ga                                     CH.sub.2 F  H      H      H             Ga                                     CH.sub.2 F  H      H      Me            Gb                                     CH.sub.2 F  H      H      Et            Gb                                     CH.sub.2 F  H      H      Pr-n          Gb                                     CH.sub.2 F  H      H      Pr-i          Gb                                     CH.sub.2 F  H      H      Bu-n          Gc                                     CH.sub.2 F  Me     H      H             Ga                                     CH.sub.2 F  Et     H      H             Gb                                     CH.sub.2 F  Me     H      Me            Gb                                     CH.sub.2 F  Me     H      Et            Gb                                     CH.sub.2 F  H      Me     Me            Ga                                     CH.sub.2 F  H      Me     Et            Gb                                     CH.sub.2 F  H      H      F             Ga                                     CH.sub.2 F  H      H      Cl            Ga                                     CH.sub.2 F  H      H      Br            Gb                                     CH.sub.2 F  H      H      I             Gb                                     CH.sub.2 F  H      H      CF.sub.3      Ga                                     CH.sub.2 F  H      H      CH.sub.2 F    Ga                                     CH.sub.2 F  H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 F  H      H      CH.sub.2 Br   Gb                                     CH.sub.2 F  H      H      CH.sub.2 I    Gb                                     CH.sub.2 F  H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     CH.sub.2 F  H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     CH.sub.2 F  H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     CH.sub.2 F  H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     CH.sub.2 F  H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     CH.sub.2 F  H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     CH.sub.2 F  H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     CH.sub.2 F  H      H      CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     CH.sub.2 F  H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 F  H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 F  H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     CH.sub.2 F  H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     CH.sub.2 F  H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     CH.sub.2 F  H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     CH.sub.2 F  H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 F  H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 F  H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 F  H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 F  H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 F  H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 F  H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 F  H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 F  H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 F  H      H      CH.sub.2 CN   Ga                                     CH.sub.2 F  H      H      CO.sub.2 Me   Ga                                     CH.sub.2 F  H      H      CO.sub.2 Et   Ga                                     CH.sub.2 F  H      H      CO.sub.2 Pr-n Gb                                     CH.sub.2 F  H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 F  H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 F  H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     CH.sub.2 F  H      H      COMe          Ga                                     CH.sub.2 F  H      H      COEt          Ga                                     CH.sub.2 F  H      H      COPr-n        Gb                                     CH.sub.2 F  H      H      CH.sub.2 COMe Ga                                     CH.sub.2 F  H      H      CH.sub.2 COEt Ga                                     CH.sub.2 Cl H      H      H             Ga                                     CH.sub.2 Cl H      H      Me            Gb                                     CH.sub.2 Cl H      H      Et            Gb                                     CH.sub.2 Cl H      H      Pr-n          Gb                                     CH.sub.2 Cl H      H      Pr-i          Gb                                     CH.sub.2 Cl H      H      Bu-n          Gc                                     CH.sub.2 Cl Me     H      H             Ga                                     CH.sub.2 Cl Et     H      H             Gb                                     CH.sub.2 Cl Me     H      Me            Gb                                     CH.sub.2 Cl Me     H      Et            Gb                                     CH.sub.2 Cl H      Me     Me            Ga                                     CH.sub.2 Cl H      Me     Et            Gb                                     CH.sub.2 Cl H      H      F             Ga                                     CH.sub.2 Cl H      H      Cl            Ga                                     CH.sub.2 Cl H      H      Br            Gb                                     CH.sub.2 Cl H      H      I             Gb                                     CH.sub. 2 Cl                                                                               H      H      CF.sub.3      Ga                                     CH.sub.2 Cl H      H      CH.sub.2 F    Ga                                     CH.sub.2 Cl H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 Cl H      H      CH.sub.2 Br   Gb                                     CH.sub.2 Cl H      H      CH.sub.2 I    Gb                                     CH.sub.2 Cl H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     CH.sub.2 Cl H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     CH.sub.2 Cl H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     CH.sub.2 Cl H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     CH.sub.2 Cl H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     CH.sub.2 Cl H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     CH.sub.2 Cl H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     CH.sub.2 Cl H      H      CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     CH.sub.2 Cl H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 Cl H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 Cl H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     CH.sub.2 Cl H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     CH.sub.2 Cl H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     CH.sub.2 Cl H      H      CH(CH.sub.3)CH.sub. 2 OEt                                                                    Gb                                     CH.sub.2 Cl H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 Cl H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 Cl H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 Cl H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 Cl H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 Cl H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 Cl H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 Cl H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 Cl H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 Cl H      H      CH.sub.2 CN   Ga                                     CH.sub.2 Cl H      H      CO.sub.2 Me   Ga                                     CH.sub.2 Cl H      H      CO.sub.2 Et   Ga                                     CH.sub.2 Cl H      H      CO.sub.2 Pr-n Gb                                     CH.sub.2 Cl H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 Cl H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 Cl H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     CH.sub.2 Cl H      H      COMe          Ga                                     CH.sub.2 Cl H      H      COEt          Ga                                     CH.sub.2 Cl H      H      COPr-n        Gb                                     CH.sub.2 Cl H      H      CH.sub.2 COMe Ga                                     CH.sub.2 Cl H      H      CH.sub.2 COEt Ga                                     CH.sub.2 Br H      H      H             Ga                                     CH.sub.2 Br H      H      Me            Gb                                     CH.sub.2 Br H      H      Et            Gb                                     CH.sub.2 Br Me     H      H             Ga                                     CH.sub.2 Br Et     H      H             Gb                                     CH.sub.2 Br Me     H      Me            Gb                                     CH.sub.2 Br Me     H      Et            Gb                                     CH.sub.2 Br H      Me     Me            Ga                                     CH.sub.2 Br H      Me     Et            Gb                                     CH.sub.2 Br H      H      CF.sub.3      Ga                                     CH.sub.2 Br H      H      CH.sub.2 F    Ga                                     CH.sub.2 Br H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 Br H      H      CH.sub.2 Br   Gb                                     CH.sub.2 Br H      H      CH.sub.2 I    Gb                                     CH.sub.2 Br H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 Br H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 Br H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 Br H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 Br H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 Br H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 Br H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 Br H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 Br H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 Br H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 Br H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 Br H      H      CH.sub.2 CN   Ga                                     CH.sub.2 Br H      H      CO.sub.2 Me   Ga                                     CH.sub.2 Br H      H      CO.sub.2 Et   Ga                                     CH.sub.2 Br H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 Br H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 Br H      H      COMe          Ga                                     CH.sub.2 Br H      H      COEt          Ga                                     CH.sub.2 Br H      H      CH.sub.2 COMe Ga                                     CH.sub.2 Br H      H      CH.sub.2 COEt Ga                                     CH.sub.2 I  H      H      H             Ga                                     CH.sub.2 I  H      H      Me            Gb                                     CH.sub.2 I  H      H      Et            Gb                                     CH.sub.2 I  Me     H      H             Ga                                     CH.sub.2 I  Et     H      H             Gb                                     CH.sub.2 I  Me     H      Me            Gb                                     CH.sub.2 I  Me     H      Et            Gb                                     CH.sub.2 I  H      Me     Me            Ga                                     CH.sub.2 I  H      Me     Et            Gb                                     CH.sub.2 I  H      H      CF.sub.3      Ga                                     CH.sub.2 I  H      H      CH.sub.2 F    Ga                                     CH.sub.2 I  H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 I  H      H      CH.sub.2 Br   Gb                                     CH.sub.2 I  H      H      CH.sub.2 I    Gb                                     CH.sub.2 I  H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 I  H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 I  H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 I  H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 I  H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 I  H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 I  H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 I  H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 I  H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 I  H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 I  H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 I  H      H      CH.sub.2 CN   Ga                                     CH.sub.2 I  H      H      CO.sub.2 Me   Ga                                     CH.sub.2 I  H      H      CO.sub.2 Et   Ga                                     CH.sub.2 I  H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 I  H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 I  H      H      COMe          Ga                                     CH.sub.2 I  H      H      COEt          Ga                                     CH.sub.2 I  H      H      CH.sub.2 COMe Ga                                     CH.sub.2 I  H      H      CH.sub.2 COEt Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      H             Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      Me            Gb                                     CH.sub.2 CH.sub.2 F                                                                        H      H      Et            Gb                                     CH.sub.2 CH.sub.2 F                                                                        Me     H      H             Ga                                     CH.sub.2 CH.sub.2 F                                                                        Et     H      H             Gb                                     CH.sub.2 CH.sub.2 F                                                                        Me     H      Me            Gb                                     CH.sub.2 CH.sub.2 F                                                                        Me     H      Et            Gb                                     CH.sub.2 CH.sub.2 F                                                                        H      Me     Me            Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      Me     Et            Gb                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CF.sub.3      Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 F    Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 I    Gb                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CH.sub. 2 F                                                                       H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CO.sub.2 Et   Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      COMe          Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      COEt          Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CH.sub.2 F                                                                        H      H      CH.sub.2 COEt Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      H             Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      Me            Gb                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      Et            Gb                                     CH.sub.2 CH.sub.2 Cl                                                                       Me     H      H             Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       Et     H      H             Gb                                     CH.sub.2 CH.sub.2 Cl                                                                       Me     H      Me            Gb                                     CH.sub.2 CH.sub.2 Cl                                                                       Me     H      Et            Gb                                     CH.sub.2 CH.sub.2 Cl                                                                       H      Me     Me            Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      Me     Et            Gb                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CF.sub.3      Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 F    Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 I    Gb                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CH.sub. 2 Cl                                                                      H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CO.sub.2 Et   Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      COMe          Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      COEt          Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CH.sub.2 Cl                                                                       H      H      CH.sub.2 COEt Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      H             Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      Me            Gb                                     CH.sub.2 CH.sub.2 Br                                                                       Me     H      H             Ga                                     CH.sub.2 CH.sub.2 Br                                                                       Me     H      Me            Gb                                     CH.sub.2 CH.sub.2 Br                                                                       H      Me     Me            Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CF.sub.3      Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 F    Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 I    Gb                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 CN   Ga                                     CH.sub. 2 CH.sub.2 Br                                                                      H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      COMe          Ga                                     CH.sub.2 CH.sub.2 Br                                                                       H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      H             Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      Me            Gb                                     CH.sub.2 CH.sub.2 I                                                                        Me     H      H             Ga                                     CH.sub.2 CH.sub.2 I                                                                        Me     H      Me            Gb                                     CH.sub.2 CH.sub.2 I                                                                        H      Me     Me            Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CF.sub.3      Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 F    Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 I    Gb                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 OCH.sub.2 CH CH.sub.2                                                               Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      COMe          Ga                                     CH.sub.2 CH.sub.2 I                                                                        H      H      CH.sub.2 COMe Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      H             Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      Et            Gb                                     CH(CH.sub.3)CH.sub.2 F                                                                     Me     H      H             Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     Et     H      H             Gb                                     CH(CH.sub.3)CH.sub.2 F                                                                     Me     H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 F                                                                     Me     H      Et            Gb                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      Me     Me            Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      Me     Et            Gb                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CF.sub.3      Ga                                     CH(CH.sub.3)CH.sub. 2 F                                                                    H      H      CH.sub.2 F    Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 Cl   Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 Br   Gb                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 I    Gb                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 OMe  Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 OEt  Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 SMe  Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 SEt  Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 CN   Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CO.sub.2 Me   Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CO.sub.2 Et   Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      COMe          Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      COEt          Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 COMe Ga                                     CH(CH.sub.3)CH.sub.2 F                                                                     H      H      CH.sub.2 COEt Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      H             Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      Et            Gb                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    Me     H      H             Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    Et     H      H             Gb                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    Me     H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    Me     H      Et            Gb                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      Me     Me            Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      Me     Et            Gb                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CF.sub.3      Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 F    Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 Cl   Ga                                     CH(CH.sub.3)CH.sub. 2 Cl                                                                   H      H      CH.sub.2 Br   Gb                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 I    Gb                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 OMe  Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 OEt  Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 OCH.sub.2 CH CH.sub.2                                                               Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 SMe  Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 SEt  Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 CN   Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CO.sub.2 Me   Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CO.sub.2 Et   Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      COMe          Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      COEt          Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 COMe Ga                                     CH(CH.sub.3)CH.sub.2 Cl                                                                    H      H      CH.sub.2 COEt Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      H             Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 Br                                                                    Me     H      H             Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    Me     H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      Me     Me            Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CF.sub.3      Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 F    Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 Cl   Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 Br   Gb                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 I    Gb                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 OMe  Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 SMe  Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 CN   Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CO.sub.2 Me   Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      COMe          Ga                                     CH(CH.sub.3)CH.sub.2 Br                                                                    H      H      CH.sub.2 COMe Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      H             Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 I                                                                     Me     H      H             Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     Me     H      Me            Gb                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      Me     Me            Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CF.sub.3      Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 F    Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 Cl   Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 Br   Gb                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 I    Gb                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 OMe  Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 SMe  Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 CN   Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CO.sub.2 Me   Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      COMe          Ga                                     CH(CH.sub.3)CH.sub.2 I                                                                     H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CF.sub. 3                                                                         H      H      H             Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      Me            Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      Et            Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      Pr-n          Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      Pr-i          Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      Bu-n          Gc                                     CH.sub.2 CF.sub.3                                                                          Me     H      H             Ga                                     CH.sub.2 CF.sub.3                                                                          Et     H      H             Gb                                     CH.sub.2 CF.sub.3                                                                          Me     H      Me            Gb                                     CH.sub.2 CF.sub.3                                                                          Me     H      Et            Gb                                     CH.sub.2 CF.sub.3                                                                          H      Me     Me            Ga                                     CH.sub.2 CF.sub.3                                                                          H      Me     Et            Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      F             Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      Cl            Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      Br            Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      I             Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CF.sub.3      Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 F    Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 I    Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CO.sub.2 Et   Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CO.sub.2 Pr-n Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      COMe          Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      COEt          Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      COPr-n        Gb                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CF.sub.3                                                                          H      H      CH.sub.2 COEt Ga                                     CH.sub.2 CN H      H      H             Ga                                     CH.sub.2 CN H      H      Me            Gb                                     CH.sub.2 CN H      H      Et            Gb                                     CH.sub.2 CN H      H      Pr-n          Gb                                     CH.sub. 2 CN                                                                               H      H      Pr-i          Gb                                     CH.sub.2 CN H      H      Bu-n          Gc                                     CH.sub.2 CN Me     H      H             Ga                                     CH.sub.2 CN Et     H      H             Gb                                     CH.sub.2 CN Me     H      Me            Gb                                     CH.sub.2 CN Me     H      Et            Gb                                     CH.sub.2 CN H      Me     Me            Ga                                     CH.sub.2 CN H      Me     Et            Gb                                     CH.sub.2 CN H      H      F             Ga                                     CH.sub.2 CN H      H      Cl            Ga                                     CH.sub.2 CN H      H      Br            Gb                                     CH.sub.2 CN H      H      I             Gb                                     CH.sub.2 CN H      H      CF.sub.3      Ga                                     CH.sub.2 CN H      H      CH.sub.2 F    Ga                                     CH.sub.2 CN H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CN H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CN H      H      CH.sub.2 I    Gb                                     CH.sub.2 CN H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     CH.sub.2 CN H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     CH.sub.2 CN H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     CH.sub.2 CN H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     CH.sub.2 CN H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     CH.sub.2 CN H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga -CH.sub.2 CN H H CH(CH.sub.3                                                )CH.sub.2 Br Gb                        CH.sub.2 CN H      H      CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     CH.sub.2 CN H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CN H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 CN H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     CH.sub.2 CN H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     CH.sub.2 CN H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     CH.sub.2 CN H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     CH.sub.2 CN H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CN H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CN H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CN H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CN H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CN H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 CN H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CN H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 CN H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CN H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CN H      H      CO.sub.2 Me   Ga                                     CH.sub. 2 CN                                                                               H      H      CO.sub.2 Et   Ga                                     CH.sub.2 CN H      H      CO.sub.2 Pr-n Gb                                     CH.sub.2 CN H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CN H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CN H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     CH.sub.2 CN H      H      COMe          Ga                                     CH.sub.2 CN H      H      COEt          Ga                                     CH.sub.2 CN H      H      COPr-n        Gb                                     CH.sub.2 CN H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CN H      H      CH.sub.2 COEt Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      H             Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      Me            Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      Et            Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      Pr-n          Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      Pr-i          Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      Bu-n          Gc                                     CH.sub.2 CO.sub.2 Me                                                                       Me     H      H             Ga                                     CH.sub.2 CO.sub.2 Me                                                                       Et     H      H             Gb                                     CH.sub.2 CO.sub.2 Me                                                                       Me     H      Me            Gb                                     CH.sub.2 CO.sub.2 Me                                                                       Me     H      Et            Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      Me     Me            Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      Me     Et            Gb                                     CH.sub.2 CO.sub. 2 Me                                                                      H      H      F             Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      Cl            Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      Br            Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      I             Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CF.sub.3      Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 F    Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 I    Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CO.sub.2 Et   Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CO.sub.2 Pr-n Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      COMe          Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      COEt          Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      COPr-n        Gb                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CO.sub.2 Me                                                                       H      H      CH.sub.2 COEt Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      H             Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      Me            Gb                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      Et            Gb                                     CH.sub.2 CO.sub.2 Et                                                                       Me     H      H             Ga                                     CH.sub.2 CO.sub.2 Et                                                                       Et     H      H             Gb                                     CH.sub.2 CO.sub.2 Et                                                                       Me     H      Me            Gb                                     CH.sub.2 CO.sub.2 Et                                                                       Me     H      Et            Gb                                     CH.sub.2 CO.sub.2 Et                                                                       H      Me     Me            Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      Me     Et            Gb                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CF.sub.3      Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 F    Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 I    Gb                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CO.sub.2 Et   Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      COMe          Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      COEt          Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 COMe Ga                                     CH.sub.2 CO.sub.2 Et                                                                       H      H      CH.sub.2 COEt Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      H             Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      Me            Gb                                     CH.sub.2 CO.sub.2 Pr-n                                                                     Me     H      H             Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     Me     H      Me            Gb                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      Me     Me            Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CF.sub.3      Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 F    Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 Br   Gb                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 I    Gb                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 CN   Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CO.sub.2 Me   Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      COMe          Ga                                     CH.sub.2 CO.sub.2 Pr-n                                                                     H      H      CH.sub.2 COMe Ga                                     CH.sub.2 COMe                                                                              H      H      H             Ga                                     CH.sub.2 COMe                                                                              H      H      Me            Gb                                     CH.sub.2 COMe                                                                              H      H      Et            Gb                                     CH.sub.2 COMe                                                                              H      H      Pr-n          Gb                                     CH.sub.2 COMe                                                                              H      H      Pr-i          Gb                                     CH.sub.2 COMe                                                                              H      H      Bu-n          Gc                                     CH.sub.2 COMe                                                                              Me     H      H             Ga                                     CH.sub.2 COMe                                                                              Et     H      H             Gb                                     CH.sub.2 COMe                                                                              Me     H      Me            Gb                                     CH.sub.2 COMe                                                                              Me     H      Et            Gb                                     CH.sub.2 COMe                                                                              H      Me     Me            Ga                                     CH.sub.2 COMe                                                                              H      Me     Et            Gb                                     CH.sub.2 COMe                                                                              H      H      F             Ga                                     CH.sub.2 COMe                                                                              H      H      Cl            Ga                                     CH.sub.2 COMe                                                                              H      H      Br            Gb                                     CH.sub.2 COMe                                                                              H      H      I             Gb                                     CH.sub.2 COMe                                                                              H      H      CF.sub.3      Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 F    Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 Br   Gb                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 I    Gb                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CH.sub.2 F                                                                          Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CH.sub.2 Br                                                                         Gb                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CH.sub.2 I                                                                          Gb                                     CH.sub.2 COMe                                                                              H      H      CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     CH.sub.2 COMe                                                                              H      H      CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     CH.sub.2 COMe                                                                              H      H      CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     CH.sub.2 COMe                                                                              H      H      CH(CH.sub.3 )CH.sub.2 I                                                                      Gb                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 OEt  Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     CH.sub.2 COMe                                                                              H      H      CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     CH.sub.2 COMe                                                                              H      H      CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CN   Ga                                     CH.sub.2 COMe                                                                              H      H      CO.sub.2 Me   Ga                                     CH.sub.2 COMe                                                                              H      H      CO.sub.2 Et   Ga                                     CH.sub.2 COMe                                                                              H      H      CO.sub.2 Pr-n Gb                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     CH.sub.2 COMe                                                                              H      H      COMe          Ga                                     CH.sub.2 COMe                                                                              H      H      COEt          Ga                                     CH.sub.2 COMe                                                                              H      H      COPr-n        Gb                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 COMe Ga                                     CH.sub.2 COMe                                                                              H      H      CH.sub.2 COEt Ga                                     CH.sub.2 COEt                                                                              H      H      H             Ga                                     CH.sub.2 COEt                                                                              H      H      Me            Gb                                     CH.sub.2 COEt                                                                              H      H      Et            Gb                                     CH.sub.2 COEt                                                                              Me     H      H             Ga                                     CH.sub.2 COEt                                                                              Et     H      H             Gb                                     CH.sub.2 COEt                                                                              Me     H      Me            Gb                                     CH.sub.2 COEt                                                                              Me     H      Et            Gb                                     CH.sub.2 COEt                                                                              H      Me     Me            Ga                                     CH.sub.2 COEt                                                                              H      Me     Et            Gb                                     CH.sub.2 COEt                                                                              H      H      CF.sub.3      Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 F    Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 Cl   Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 Br   Gb                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 I    Gb                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 OMe  Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub. 2 OEt Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 SMe  Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 SEt  Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 CN   Ga                                     CH.sub.2 COEt                                                                              H      H      CO.sub.2 Me   Ga                                     CH.sub.2 COEt                                                                              H      H      CO.sub.2 Et   Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 COEt                                                                              H      H      COMe          Ga                                     CH.sub.2 COEt                                                                              H      H      COEt          Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 COMe Ga                                     CH.sub.2 COEt                                                                              H      H      CH.sub.2 COEt Ga                                     Ph          H      H      H             Ga                                     Ph          H      H      Me            Ga                                     PhCH.sub.2  H      H      H             Gb                                     PhCH.sub.2  H      H      Me            Gb                                     Me          H      H      Ph            Ga                                     Me          H      H      PhCH.sub.2    Gb                                     Me          H      H      CH.sub.2 CHCH.sub.2                                                                          Ga                                     Me          H      H      CH.sub.2 CCH  Ga                                     Bu-t        H      H      H             Gb                                     ______________________________________                                    

                                      TABLE 8                                      __________________________________________________________________________      ##STR151##                                                                    R.sup.21   R.sup.25                                                                           R.sup.26                                                                           R.sup.27                                                                           R.sup.28    Gn                                          __________________________________________________________________________     H          H   H   H   H           Ga                                          H          H   H   H   Me          Ga                                          H          H   H   H   Et          Ga                                          H          H   H   H   Pr-n        Gb                                          H          Me  H   H   H           Ga                                          H          H   Me  H   H           Ga                                          H          Me  H   H   Me          Gb                                          H          Me  Me  H   Me          Gb                                          H          H   H   Me  Me          Gb                                          Me         H   H   H   H           Ga                                          Me         H   H   H   Me          Ga                                          Me         H   H   H   Et          Ga                                          Me         H   H   H   Pr-n        Gb                                          Me         Me  H   H   H           Ga                                          Me         H   Me  H   H           Ga                                          Me         Me  H   H   Me          Gb                                          Me         Me  Me  H   Me          Gb                                          Me         H   H   Me  Me          Gb                                          Me         H   H   H   CF.sub.3    Gb                                          Me         H   H   H   CH.sub.2 F  Gb                                          Me         H   H   H   CH.sub.2 Cl Gb                                          Me         H   H   H   CH.sub.2 Br Gb                                          Me         H   H   H   CH.sub.2 I  Gb                                          Me         H   H   H   CH.sub.2 OMe                                                                               Gb                                          Me         H   H   H   CH.sub.2 OEt                                                                               Gb                                          Me         H   H   H   CH.sub.2 OCH.sub.2 CHCH.sub.2                                                              Gb                                          Me         H   H   H   CH.sub.2 OCH.sub.2 CCH                                                                     Gb                                          Me         H   H   H   CH.sub.2 SMe                                                                               Gb                                          Me         H   H   H   CH.sub.2 SO.sub.2 Me                                                                       Gb                                          Me         H   H   H   CH.sub.2 CN Gb                                          Me         H   H   H   CO.sub.2 Me Gb                                          Me         H   H   H   CO.sub.2 Et Gb                                          Me         H   H   H   COMe        Gb                                          Me         H   H   H   COEt        Gb                                          Me         H   H   H   CH.sub.2 CO.sub.2 Me                                                                       Gb                                          Me         H   H   H   CH.sub.2 CO.sub.2 Et                                                                       Gb                                          Me         H   H   H   CH.sub.2 COMe                                                                              Gb                                          Me         H   H   H   CH.sub.2 COEt                                                                              Gb                                          Et         H   H   H   H           Ga                                          Et         H   H   H   Me          Ga                                          Et         H   H   H   Et          Ga                                          Et         H   H   H   Pr-n        Gb                                          Et         Me  H   H   H           Ga                                          Et         H   Me  H   H           Ga                                          Et         Me  H   H   Me          Gb                                          Et         Me  Me  H   Me          Gb                                          Et         H   H   Me  Me          Gb                                          Et         H   H   H   CF.sub.3    Gb                                          Et         H   H   H   CH.sub.2 F  Gb                                          Et         H   H   H   CH.sub.2 Cl Gb                                          Et         H   H   H   CH.sub.2 Br Gb                                          Et         H   H   H   CH.sub.2 I  Gb                                          Et         H   H   H   CH.sub.2 OMe                                                                               Gb                                          Et         H   H   H   CH.sub.2 OEt                                                                               Gb                                          Et         H   H   H   CH.sub.2 CN Gb                                          Et         H   H   H   COMe        Gb                                          Et         H   H   H   COEt        Gb                                          Et         H   H   H   CH.sub.2 CO.sub.2 Me                                                                       Gb                                          Et         H   H   H   CH.sub.2 CO.sub.2 Et                                                                       Gb                                          Et         H   H   H   CH.sub.2 COMe                                                                              Gb                                          Et         H   H   H   CH.sub.2 COEt                                                                              Gb                                          Pr-n       H   H   H   H           Ga                                          Pr-n       H   H   H   Me          Ga                                          Pr-n       H   H   H   Et          Ga                                          Pr-n       H   H   H   Pr-n        Gb                                          Pr-n       Me  H   H   H           Ga                                          Pr-n       H   Me  H   H           Ga                                          Pr-n       Me  H   H   Me          Gb                                          Pr-n       Me  Me  H   Me          Gb                                          Pr-n       H   H   Me  Me          Gb                                          Pr-n       H   H   H   CF.sub.3    Gb                                          Pr-n       H   H   H   CH.sub.2 F  Gb                                          Pr-n       H   H   H   CH.sub.2 Cl Gb                                          Pr-n       H   H   H   CH.sub.2 Br Gb                                          Pr-n       H   H   H   CH.sub.2 I  Gb                                          Pr-n       H   H   H   CH.sub.2 OMe                                                                               Gb                                          Pr-n       H   H   H   CH.sub.2 OEt                                                                               Gb                                          Pr-i       H   H   H   H           Ga                                          Pr-i       H   H   H   Me          Ga                                          Pr-i       H   H   H   Et          Ga                                          Pr-i       H   H   H   Pr-n        Gb                                          Pr-i       Me  H   H   H           Ga                                          Pr-i       H   Me  H   H           Ga                                          Pr-i       Me  H   H   Me          Gb                                          Pr-i       Me  Me  H   Me          Gb                                          Pr-i       H   H   Me  Me          Gb                                          Bu-n       H   H   H   H           Ga                                          Bu-n       H   H   H   Me          Ga                                          Bu-n       H   H   H   Et          Ga                                          Bu-n       H   H   H   Pr-n        Gb                                          CH.sub.2 CHCH.sub.2                                                                       H   H   H   H           Ga                                          CH.sub.2 CHCH.sub.2                                                                       H   H   H   Me          Ga                                          CH.sub.2 CHCH.sub.2                                                                       H   H   H   Et          Ga                                          CH.sub.2 CHCH.sub.2                                                                       H   H   H   Pr-n        Gb                                          CH.sub.2 CHCH.sub.2                                                                       Me  H   H   H           Ga                                          CH.sub.2 CHCH.sub.2                                                                       H   Me  H   H           Ga                                          CH.sub.2 CHCH.sub.2                                                                       Me  H   H   Me          Gb                                          CH.sub.2 CHCH.sub.2                                                                       Me  Me  H   Me          Gb                                          CH.sub.2 CHCH.sub.2                                                                       H   H   Me  Me          Gb                                          CH.sub.2 CCH                                                                              H   H   H   H           Ga                                          CH.sub.2 CCH                                                                              H   H   H   Me          Ga                                          CH.sub.2 CCH                                                                              H   H   H   Et          Ga                                          CH.sub.2 CCH                                                                              H   H   H   Pr-n        Gb                                          CH.sub.2 CCH                                                                              Me  H   H   H           Ga                                          CH.sub.2 CCH                                                                              H   Me  H   H           Ga                                          CH.sub.2 CCH                                                                              Me  H   H   Me          Gb                                          CH.sub.2 CCH                                                                              Me  Me  H   Me          Gb                                          CH.sub.2 CCH                                                                              H   H   Me  Me          Gb                                          CH.sub.2 OMe                                                                              H   H   H   H           Ga                                          CH.sub.2 OMe                                                                              H   H   H   Me          Ga                                          CH.sub.2 OMe                                                                              H   H   H   Et          Ga                                          CH.sub.2 OMe                                                                              H   H   H   Pr-n        Gb                                          CH.sub.2 OMe                                                                              Me  H   H   H           Ga                                          CH.sub.2 OMe                                                                              H   Me  H   H           Ga                                          CH.sub.2 OMe                                                                              Me  H   H   Me          Gb                                          CH.sub.2 OMe                                                                              Me  Me  H   Me          Gb                                          CH.sub.2 OMe                                                                              H   H   Me  Me          Gb                                          CH.sub.2 OMe                                                                              H   H   H   CF.sub.3    Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 OCH.sub.2 CHCH.sub.2                                                              Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 OCH.sub.2 CCH                                                                     Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 SMe                                                                               Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 SO.sub.2 Me                                                                       Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 CN Gb                                          CH.sub.2 OMe                                                                              H   H   H   CO.sub.2 Me Gb                                          CH.sub.2 OMe                                                                              H   H   H   CO.sub.2 Et Gb                                          CH.sub.2 OMe                                                                              H   H   H   COMe        Gb                                          CH.sub.2 OMe                                                                              H   H   H   COEt        Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 CO.sub.2 Me                                                                       Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 CO.sub.2 Et                                                                       Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 COMe                                                                              Gb                                          CH.sub.2 OMe                                                                              H   H   H   CH.sub.2 COEt                                                                              Gb                                          CH.sub.2 OEt                                                                              H   H   H   H           Ga                                          CH.sub.2 OEt                                                                              H   H   H   Me          Ga                                          CH.sub.2 OEt                                                                              H   H   H   Et          Ga                                          CH.sub.2 OEt                                                                              H   H   H   Pr-n        Gb                                          CH.sub.2 OEt                                                                              Me  H   H   H           Ga                                          CH.sub.2 OEt                                                                              H   Me  H   H           Ga                                          CH.sub.2 OEt                                                                              Me  H   H   Me          Gb                                          CH.sub.2 OEt                                                                              Me  Me  H   Me          Gb                                          CH.sub.2 OEt                                                                              H   H   Me  Me          Gb                                          CH.sub.2 OEt                                                                              H   H   H   CF.sub.3    Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 CN Gb                                          CH.sub.2 OEt                                                                              H   H   H   COMe        Gb                                          CH.sub.2 OEt                                                                              H   H   H   COEt        Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 CO.sub.2 Me                                                                       Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 CO.sub.2 Et                                                                       Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 COMe                                                                              Gb                                          CH.sub.2 OEt                                                                              H   H   H   CH.sub.2 COEt                                                                              Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   H           Ga                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   Me          Ga                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   Et          Ga                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   Pr-n        Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     Me  H   H   H           Ga                                          CH.sub.2 CH.sub.2 OMe                                                                     H   Me  H   H           Ga                                          CH.sub.2 CH.sub.2 OMe                                                                     Me  H   H   Me          Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     Me  Me  H   Me          Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   Me  Me          Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CF.sub.3    Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 CN Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   COMe        Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   COEt        Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 CO.sub.2 Me                                                                       Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 CO.sub.2 Et                                                                       Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 COMe                                                                              Gb                                          CH.sub.2 CH.sub.2 OMe                                                                     H   H   H   CH.sub.2 COEt                                                                              Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   H           Ga                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   Me          Ga                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   Et          Ga                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   Pr-n        Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     Me  H   H   H           Ga                                          CH.sub.2 CH.sub.2 OEt                                                                     H   Me  H   H           Ga                                          CH.sub.2 CH.sub.2 OEt                                                                     Me  H   H   Me          Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     Me  Me  H   Me          Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   Me  Me          Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   CF.sub.3    Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 CH.sub.2 OEt                                                                     H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   Me          Ga                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   Et          Ga                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   Pr-n        Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  Me  H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   Me  H   H           Ga                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  Me  H   H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  Me  Me  H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   Me  Me          Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   CF.sub.3    Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   CH.sub.2 F  Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   CH.sub.2 Cl Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   CH.sub.2 Br Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   CH.sub.2 I  Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH(CH.sub.3)CH.sub.2 OMe                                                                  H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH(CH.sub.3)CH.sub.2 OEt                                                                  H   H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 OEt                                                                  H   H   H   Me          Ga                                          CH(CH.sub.3)CH.sub.2 OEt                                                                  H   H   H   Et          Ga                                          CH(CH.sub.3)CH.sub.2 OEt                                                                  H   H   H   Pr-N        Gb                                          CH(CH.sub.3)CH.sub.2 OEt                                                                  Me  H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 OEt                                                                  H   Me  H   H           Ga                                          CH(CH.sub.3)CH.sub.2 OEt                                                                  Me  H   H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 OEt                                                                  Me  Me  H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 OEt                                                                  H   H   Me  Me          Gb                                          CH.sub.2 OCHF.sub.2                                                                       H   H   H   H           Ga                                          CH.sub.2 OCHF.sub.2                                                                       H   H   H   Me          Ga                                          CH.sub.2 OCHF.sub.2                                                                       H   H   H   Et          Ga                                          CH.sub.2 OCHF.sub.2                                                                       H   H   H   Pr-n        Gb                                          CH.sub.2 OCHF.sub.2                                                                       Me  H   H   H           Ga                                          CH.sub.2 OCHF.sub.2                                                                       H   Me  H   H           Ga                                          CH.sub.2 OCHF.sub.2                                                                       Me  H   H   Me          Gb                                          CH.sub.2 OCHF.sub.2                                                                       Me  Me  H   Me          Gb                                          CH.sub.2 OCHF.sub.2                                                                       H   H   Me  Me          Gb                                          CH.sub.2 SMe                                                                              H   H   H   H           Ga                                          CH.sub.2 SMe                                                                              H   H   H   Me          Ga                                          CH.sub.2 SMe                                                                              H   H   H   Et          Ga                                          CH.sub.2 SMe                                                                              H   H   H   Pr-n        Gb                                          CH.sub.2 SMe                                                                              Me  H   H   H           Ga                                          CH.sub.2 SMe                                                                              H   Me  H   H           Ga                                          CH.sub.2 SMe                                                                              Me  H   H   Me          Gb                                          CH.sub.2 SMe                                                                              Me  Me  H   Me          Gb                                          CH.sub.2 SMe                                                                              H   H   Me  Me          Gb                                          CH.sub.2 SMe                                                                              H   H   H   CF.sub.3    Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 OCH.sub.2 CHCH.sub.2                                                              Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 OCH.sub.2 CCH                                                                     Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 SMe                                                                               Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 SO.sub.2 Me                                                                       Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 CN Gb                                          CH.sub.2 SMe                                                                              H   H   H   CO.sub.2 Me Gb                                          CH.sub.2 SMe                                                                              H   H   H   CO.sub.2 Et Gb                                          CH.sub.2 SMe                                                                              H   H   H   COMe        Gb                                          CH.sub.2 SMe                                                                              H   H   H   COEt        Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 CO.sub.2 Me                                                                       Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 CO.sub.2 Et                                                                       Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 COMe                                                                              Gb                                          CH.sub.2 SMe                                                                              H   H   H   CH.sub.2 COEt                                                                              Gb                                          CH.sub.2 SEt                                                                              H   H   H   H           Ga                                          CH.sub.2 SEt                                                                              H   H   H   Me          Ga                                          CH.sub.2 SEt                                                                              H   H   H   Et          Ga                                          CH.sub.2 SEt                                                                              H   H   H   Pr-n        Gb                                          CH.sub.2 SEt                                                                              Me  H   H   H           Ga                                          CH.sub.2 SEt                                                                              H   Me  H   H           Ga                                          CH.sub.2 SEt                                                                              Me  H   H   Me          Gb                                          CH.sub.2 SEt                                                                              Me  Me  H   Me          Gb                                          CH.sub.2 SEt                                                                              H   H   Me  Me          Gb                                          CH.sub.2 SEt                                                                              H   H   H   CF.sub.3    Gb                                          CH.sub.2 SEt                                                                              H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 SEt                                                                              H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 SEt                                                                              H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 SEt                                                                              H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 SEt                                                                              H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 SEt                                                                              H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   H           Ga                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   Me          Ga                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   Et          Ga                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   Pr-n        Gb                                          CH.sub.2 SO.sub.2 Me                                                                      Me  H   H   H           Ga                                          CH.sub.2 SO.sub.2 Me                                                                      H   Me  H   H           Ga                                          CH.sub.2 SO.sub.2 Me                                                                      Me  H   H   Me          Gb                                          CH.sub.2 SO.sub.2 Me                                                                      Me  Me  H   Me          Gb                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   Me  Me          Gb                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   CF.sub.3    Gb                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 SO.sub.2 Me                                                                      H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 SO.sub.2 Et                                                                      H   H   H   H           Ga                                          CH.sub.2 SO.sub.2 Et                                                                      H   H   H   Me          Ga                                          CH.sub.2 SO.sub.2 Et                                                                      H   H   H   Et          Ga                                          CH.sub.2 SO.sub.2 Et                                                                      H   H   H   Pr-n        Gb                                          CH.sub.2 SO.sub.2 Et                                                                      Me  H   H   H           Ga                                          CH.sub.2 SO.sub.2 Et                                                                      H   Me  H   H           Ga                                          CH.sub.2 SO.sub.2 Et                                                                      Me  H   H   Me          Gb                                          CH.sub.2 SO.sub.2 Et                                                                      Me  Me  H   Me          Gb                                          CH.sub.2 SO.sub.2 Et                                                                      H   H   Me  Me          Gb                                          CH.sub.2 F H   H   H   H           Ga                                          CH.sub.2 F H   H   H   Me          Ga                                          CH.sub.2 F H   H   H   Et          Ga                                          CH.sub.2 F H   H   H   Pr-n        Gb                                          CH.sub.2 F Me  H   H   H           Ga                                          CH.sub.2 F H   Me  H   H           Ga                                          CH.sub.2 F Me  H   H   Me          Gb                                          CH.sub.2 F Me  Me  H   Me          Gb                                          CH.sub.2 F H   H   Me  Me          Gb                                          CH.sub.2 F H   H   H   CF.sub.3    Gb                                          CH.sub.2 F H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 F H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 F H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 F H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 F H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 F H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 Cl                                                                               H   H   H   H           Ga                                          CH.sub.2 Cl                                                                               H   H   H   Me          Ga                                          CH.sub.2 Cl                                                                               H   H   H   Et          Ga                                          CH.sub.2 Cl                                                                               H   H   H   Pr-n        Gb                                          CH.sub.2 Cl                                                                               Me  H   H   H           Ga                                          CH.sub.2 Cl                                                                               H   Me  H   H           Ga                                          CH.sub.2 Cl                                                                               Me  H   H   Me          Gb                                          CH.sub.2 Cl                                                                               Me  Me  H   Me          Gb                                          CH.sub.2 Cl                                                                               H   H   Me  Me          Gb                                          CH.sub.2 Cl                                                                               H   H   H   CF.sub.3    Gb                                          CH.sub.2 Cl                                                                               H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 Cl                                                                               H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 Cl                                                                               H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 Cl                                                                               H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 Cl                                                                               H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 Cl                                                                               H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 Br                                                                               H   H   H   H           Ga                                          CH.sub.2 Br                                                                               H   H   H   Me          Ga                                          CH.sub.2 Br                                                                               H   H   H   Et          Ga                                          CH.sub.2 Br                                                                               H   H   H   Pr-n        Gb                                          CH.sub.2 Br                                                                               Me  H   H   H           Ga                                          CH.sub.2 Br                                                                               H   Me  H   H           Ga                                          CH.sub.2 Br                                                                               Me  H   H   Me          Gb                                          CH.sub.2 Br                                                                               Me  Me  H   Me          Gb                                          CH.sub.2 Br                                                                               H   H   Me  Me          Gb                                          CH.sub.2 Br                                                                               H   H   H   CF.sub.3    Gb                                          CH.sub.2 Br                                                                               H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 Br                                                                               H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 Br                                                                               H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 Br                                                                               H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 Br                                                                               H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 Br                                                                               H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 I H   H   H   H           Ga                                          CH.sub.2 I H   H   H   Me          Ga                                          CH.sub.2 I H   H   H   Et          Ga                                          CH.sub.2 I H   H   H   Pr-n        Gb                                          CH.sub.2 I Me  H   H   H           Ga                                          CH.sub.2 I H   Me  H   H           Ga                                          CH.sub.2 I Me  H   H   Me          Gb                                          CH.sub.2 I Me  Me  H   Me          Gb                                          CH.sub.2 I H   H   Me  Me          Gb                                          CH.sub.2 I H   H   H   CF.sub.3    Gb                                          CH.sub.2 I H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 I H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 I H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 I H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 I H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 I H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 CH.sub.2 F                                                                       H   H   H   H           Ga                                          CH.sub.2 CH.sub.2 F                                                                       H   H   H   Me          Ga                                          CH.sub.2 CH.sub.2 F                                                                       H   H   H   Et          Ga                                          CH.sub.2 CH.sub.2 F                                                                       H   H   H   Pr-n        Gb                                          CH.sub.2 CH.sub.2 F                                                                       Me  H   H   H           Ga                                          CH.sub.2 CH.sub.2 F                                                                       H   Me  H   H           Ga                                          CH.sub.2 CH.sub.2 F                                                                       Me  H   H   Me          Gb                                          CH.sub.2 CH.sub.2 F                                                                       Me  Me  H   Me          Gb                                          CH.sub.2 CH.sub.2 F                                                                       H   H   Me  Me          Gb                                          CH.sub.2 CH.sub.2 Cl                                                                      H   H   H   H           Ga                                          CH.sub.2 CH.sub.2 Cl                                                                      H   H   H   Me          Ga                                          CH.sub.2 CH.sub.2 Cl                                                                      H   H   H   Et          Ga                                          CH.sub.2 CH.sub.2 Cl                                                                      H   H   H   Pr-n        Gb                                          CH.sub.2 CH.sub.2 Cl                                                                      Me  H   H   H           Ga                                          CH.sub.2 CH.sub.2 Cl                                                                      H   Me  H   H           Ga                                          CH.sub.2 CH.sub.2 Cl                                                                      Me  H   H   Me          Gb                                          CH.sub.2 CH.sub.2 Cl                                                                      Me  Me  H   Me          Gb                                          CH.sub.2 CH.sub.2 Cl                                                                      H   H   Me  Me          Gb                                          CH.sub.2 CH.sub.2 Br                                                                      H   H   H   H           Ga                                          CH.sub.2 CH.sub.2 Br                                                                      H   H   H   Me          Ga                                          CH.sub.2 CH.sub.2 Br                                                                      H   H   H   Et          Ga                                          CH.sub.2 CH.sub.2 Br                                                                      H   H   H   Pr-n        Gb                                          CH.sub.2 CH.sub.2 Br                                                                      Me  H   H   H           Ga                                          CH.sub.2 CH.sub.2 Br                                                                      H   Me  H   H           Ga                                          CH.sub.2 CH.sub.2 Br                                                                      Me  H   H   Me          Gb                                          CH.sub.2 CH.sub.2 Br                                                                      Me  Me  H   Me          Gb                                          CH.sub.2 CH.sub.2 Br                                                                      H   H   Me  Me          Gb                                          CH.sub.2 CH.sub.2 I                                                                       H   H   H   H           Ga                                          CH.sub.2 CH.sub.2 I                                                                       H   H   H   Me          Ga                                          CH.sub.2 CH.sub.2 I                                                                       H   H   H   Et          Ga                                          CH.sub.2 CH.sub.2 I                                                                       H   H   H   Pr-n        Gb                                          CH.sub.2 CH.sub.2 I                                                                       Me  H   H   H           Ga                                          CH.sub.2 CH.sub.2 I                                                                       H   Me  H   H           Ga                                          CH.sub.2 CH.sub.2 I                                                                       Me  H   H   Me          Gb                                          CH.sub.2 CH.sub.2 I                                                                       Me  Me  H   Me          Gb                                          CH.sub.2 CH.sub.2 I                                                                       H   H   Me  Me          Gb                                          CH(CH.sub.3)CH.sub.2 F                                                                    H   H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 F                                                                    H   H   H   Me          Ga                                          CH(CH.sub.3)CH.sub.2 F                                                                    H   H   H   Et          Ga                                          CH(CH.sub.3)CH.sub.2 F                                                                    H   H   H   Pr-n        Gb                                          CH(CH.sub.3)CH.sub.2 F                                                                    Me  H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 F                                                                    H   Me  H   H           Ga                                          CH(CH.sub.3)CH.sub.2 F                                                                    Me  H   H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 F                                                                    Me  Me  H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 F                                                                    H   H   Me  Me          Gb                                          CH(CH.sub.3)CH.sub.2 Cl                                                                   H   H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 Cl                                                                   H   H   H   Me          Ga                                          CH(CH.sub.3)CH.sub.2 Cl                                                                   H   H   H   Et          Ga                                          CH(CH.sub.3)CH.sub.2 Cl                                                                   H   H   H   Pr-n        Gb                                          CH(CH.sub.3)CH.sub.2 Cl                                                                   Me  H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 Cl                                                                   H   Me  H   H           Ga                                          CH(CH.sub.3)CH.sub.2 Cl                                                                   Me  H   H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 Cl                                                                   Me  Me  H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 Cl                                                                   H   H   Me  Me          Gb                                          CH(CH.sub.3)CH.sub.2 Br                                                                   H   H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 Br                                                                   H   H   H   Me          Ga                                          CH(CH.sub.3)CH.sub.2 Br                                                                   H   H   H   Et          Ga                                          CH(CH.sub.3)CH.sub.2 Br                                                                   H   H   H   Pr-n        Gb                                          CH(CH.sub.3)CH.sub.2 Br                                                                   Me  H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 Br                                                                   H   Me  H   H           Ga                                          CH(CH.sub.3)CH.sub.2 Br                                                                   Me  H   H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 Br                                                                   Me  Me  H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 Br                                                                   H   H   Me  Me          Gb                                          CH(CH.sub.3)CH.sub.2 I                                                                    H   H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 I                                                                    H   H   H   Me          Ga                                          CH(CH.sub.3)CH.sub.2 I                                                                    H   H   H   Et          Ga                                          CH(CH.sub.3)CH.sub.2 I                                                                    H   H   H   Pr-n        Gb                                          CH(CH.sub.3)CH.sub.2 I                                                                    Me  H   H   H           Ga                                          CH(CH.sub.3)CH.sub.2 I                                                                    H   Me  H   H           Ga                                          CH(CH.sub.3)CH.sub.2 I                                                                    Me  H   H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 I                                                                    Me  Me  H   Me          Gb                                          CH(CH.sub.3)CH.sub.2 I                                                                    H   H   Me  Me          Gb                                          CH.sub.2 CF.sub.3                                                                         H   H   H   H           Ga                                          CH.sub.2 CF.sub.3                                                                         H   H   H   Me          Ga                                          CH.sub.2 CF.sub.3                                                                         H   H   H   Et          Ga                                          CH.sub.2 CF.sub.3                                                                         H   H   H   Pr-n        Gb                                          CH.sub.2 CF.sub.3                                                                         Me  H   H   H           Ga                                          CH.sub.2 CF.sub.3                                                                         H   Me  H   H           Ga                                          CH.sub.2 CF.sub.3                                                                         Me  H   H   Me          Gb                                          CH.sub.2 CF.sub.3                                                                         Me  Me  H   Me          Gb                                          CH.sub.2 CF.sub.3                                                                         H   H   Me  Me          Gb                                          CH.sub.2 CF.sub.3                                                                         H   H   H   CF.sub.3    Gb                                          CH.sub.2 CF.sub.3                                                                         H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 CF.sub.3                                                                         H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 CF.sub.3                                                                         H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 CF.sub.3                                                                         H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 CF.sub.3                                                                         H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 CF.sub.3                                                                         H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 CN                                                                               H   H   H   H           Ga                                          CH.sub.2 CN                                                                               H   H   H   Me          Ga                                          CH.sub.2 CN                                                                               H   H   H   Et          Ga                                          CH.sub.2 CN                                                                               H   H   H   Pr-n        Gb                                          CH.sub.2 CN                                                                               Me  H   H   H           Ga                                          CH.sub.2 CN                                                                               H   Me  H   H           Ga                                          CH.sub.2 CN                                                                               Me  H   H   Me          Gb                                          CH.sub.2 CN                                                                               Me  Me  H   Me          Gb                                          CH.sub.2 CN                                                                               H   H   Me  Me          Gb                                          CH.sub.2 CN                                                                               H   H   H   CF.sub.3    Gb                                          CH.sub.2 CN                                                                               H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 CN                                                                               H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 CN                                                                               H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 CN                                                                               H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 CN                                                                               H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 CN                                                                               H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   H           Ga                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   Me          Ga                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   Et          Ga                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   Pr-n        Gb                                          CH.sub.2 CO.sub.2 Me                                                                      Me  H   H   H           Ga                                          CH.sub.2 CO.sub.2 Me                                                                      H   Me  H   H           Ga                                          CH.sub.2 CO.sub.2 Me                                                                      Me  H   H   Me          Gb                                          CH.sub.2 CO.sub.2 Me                                                                      Me  Me  H   Me          Gb                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   Me  Me          Gb                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   CF.sub.3    Gb                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 CO.sub.2 Me                                                                      H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 CO.sub.2 Et                                                                      H   H   H   H           Ga                                          CH.sub.2 CO.sub.2 Et                                                                      H   H   H   Me          Ga                                          CH.sub.2 CO.sub.2 Et                                                                      H   H   H   Et          Ga                                          CH.sub.2 CO.sub.2 Et                                                                      H   H   H   Pr-n        Gb                                          CH.sub.2 CO.sub.2 Et                                                                      Me  H   H   H           Ga                                          CH.sub.2 CO.sub.2 Et                                                                      H   Me  H   H           Ga                                          CH.sub.2 CO.sub.2 Et                                                                      Me  H   H   Me          Gb                                          CH.sub.2 CO.sub.2 Et                                                                      Me  Me  H   Me          Gb                                          CH.sub.2 CO.sub.2 Et                                                                      H   H   Me  Me          Gb                                          CH.sub.2 CO.sub.2 Pr-n                                                                    H   H   H   H           Ga                                          CH.sub.2 CO.sub.2 Pr-n                                                                    H   H   H   Me          Ga                                          CH.sub.2 CO.sub.2 Pr-n                                                                    H   H   H   Et          Ga                                          CH.sub.2 CO.sub.2 Pr-n                                                                    H   H   H   Pr-n        Gb                                          CH.sub.2 CO.sub.2 Pr-n                                                                    Me  H   H   H           Ga                                          CH.sub.2 CO.sub.2 Pr-n                                                                    H   Me  H   H           Ga                                          CH.sub.2 CO.sub.2 Pr-n                                                                    Me  H   H   Me          Gb                                          CH.sub.2 CO.sub.2 Pr-n                                                                    Me  Me  H   Me          Gb                                          CH.sub.2 CO.sub.2 Pr-n                                                                    H   H   Me  Me          Gb                                          CH.sub.2 COMe                                                                             H   H   H   H           Ga                                          CH.sub.2 COMe                                                                             H   H   H   Me          Ga                                          CH.sub.2 COMe                                                                             H   H   H   Et          Ga                                          CH.sub.2 COMe                                                                             H   H   H   Pr-n        Gb                                          CH.sub.2 COMe                                                                             Me  H   H   H           Ga                                          CH.sub.2 COMe                                                                             H   Me  H   H           Ga                                          CH.sub.2 COMe                                                                             Me  H   H   Me          Gb                                          CH.sub.2 COMe                                                                             Me  Me  H   Me          Gb                                          CH.sub.2 COMe                                                                             H   H   Me  Me          Gb                                          CH.sub.2 COMe                                                                             H   H   H   CF.sub.3    Gb                                          CH.sub.2 COMe                                                                             H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 COMe                                                                             H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 COMe                                                                             H   H   H   CH.sub.2 Br Gb                                          CH.sub.2 COMe                                                                             H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 COMe                                                                             H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 COMe                                                                             H   H   H   CH.sub.2 OEt                                                                               Gb                                          CH.sub.2 COEt                                                                             H   H   H   H           Ga                                          CH.sub.2 COEt                                                                             H   H   H   Me          Ga                                          CH.sub.2 COEt                                                                             H   H   H   Et          Ga                                          CH.sub.2 COEt                                                                             H   H   H   Pr-n        Gb                                          CH.sub.2 COEt                                                                             Me  H   H   H           Ga                                          CH.sub.2 COEt                                                                             H   Me  H   H           Ga                                          CH.sub.2 COEt                                                                             Me  H   H   Me          Gb                                          CH.sub.2 COEt                                                                             Me  Me  H   Me          Gb                                          CH.sub.2 COEt                                                                             H   H   Me  Me          Gb                                          CH.sub.2 COEt                                                                             H   H   H   CF.sub.3    Gb                                          CH.sub.2 COEt                                                                             H   H   H   CH.sub.2 F  Gb                                          CH.sub.2 COEt                                                                             H   H   H   CH.sub.2 Cl Gb                                          CH.sub.2 COEt                                                                             H   H   H   CH.sub.2 Br Gb                                          CH.sub. 2 COEt                                                                            H   H   H   CH.sub.2 I  Gb                                          CH.sub.2 COEt                                                                             H   H   H   CH.sub.2 OMe                                                                               Gb                                          CH.sub.2 COEt                                                                             H   H   H   CH.sub.2 OEt                                                                               Gb                                          Ph         H   H   H   H           Ga                                          PhCH.sub.2 H   H   H   H           Gb                                          Ph         H   H   H   Me          Ga                                          PhCH.sub.2 H   H   H   Me          Gb                                          Me         H   H   H   Ph          Ga                                          Me         H   H   H   PhCH.sub.2  Gb                                          Me         H   H   H   Cl          Gb                                          Me         H   H   H   CH.sub.2CHCH.sub.2                                                                         Ga                                          Me         H   H   H   CHCCH.sub.2 Ga                                          __________________________________________________________________________

                  TABLE 9                                                          ______________________________________                                          ##STR152##                                                                    R.sup.21  R.sup.22                                                                               R.sup.23                                                                               R.sup.24      Gn                                     ______________________________________                                         Me        H       H       H             Ga                                     Me        H       H       Me            Ga                                     Me        H       H       Et            Gb                                     Me        H       H       Pr-n          Gb                                     Me        H       H       Pr-i          Gb                                     Me        H       H       Bu-n          Gc                                     Me        Me      H       H             Ga                                     Me        Et      H       H             Gb                                     Me        Me      H       Me            Gb                                     Me        Me      H       Et            Gb                                     Me        H       Me      Me            Ga                                     Me        H       Me      Et            Gb                                     Me        H       H       F             Ga                                     Me        H       H       Cl            Ga                                     Me        H       H       Br            Gb                                     Me        H       H       I             Gb                                     Me        H       H       CF.sub.3      Ga                                     Me        H       H       CH.sub.2 F    Ga                                     Me        H       H       CH.sub.2 Cl   Ga                                     Me        H       H       CH.sub.2 Br   Gb                                     Me        H       H       CH.sub.2 I    Gb                                     Me        H       H       CH.sub.2 CH.sub.2 F                                                                          Ga                                     Me        H       H       CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     Me        H       H       CH.sub.2 CH.sub.2 Br                                                                         Gb                                     Me        H       H       CH.sub.2 CH.sub.2 I                                                                          Gb                                     Me        H       H       CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     Me        H       H       CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     Me        H       H       CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     Me        H       H       CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     Me        H       H       CH.sub.2 OMe  Ga                                     Me        H       H       CH.sub.2 OEt  Ga                                     Me        H       H       CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     Me        H       H       CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     Me        H       H       CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     Me        H       H       CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     Me        H       H       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     Me        H       H       CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     Me        H       H       CH.sub.2 OCHF.sub.2                                                                          Ga                                     Me        H       H       CH.sub.2 OCF.sub.3                                                                           Ga                                     Me        H       H       CH.sub.2 SMe  Ga                                     Me        H       H       CH.sub.2 SEt  Ga                                     Me        H       H       CH.sub.2 SO.sub.2 Me                                                                         Ga                                     Me        H       H       CH.sub.2 SO.sub.2 Et                                                                         Ga                                     Me        H       H       CH.sub.2 CF.sub.3                                                                            Ga                                     Me        H       H       CH.sub.2 CN   Ga                                     Me        H       H       CO.sub.2 Me   Ga                                     Me        H       H       CO.sub.2 Et   Ga                                     Me        H       H       CO.sub.2 Pr-n Gb                                     Me        H       H       CH.sub.2 CO.sub.2 Me                                                                         Ga                                     Me        H       H       CH.sub.2 CO.sub.2 Et                                                                         Ga                                     Me        H       H       CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     Me        H       H       COMe          Ga                                     Me        H       H       COEt          Ga                                     Me        H       H       COPr-n        Gb                                     Me        H       H       CH.sub.2 COMe Ga                                     Me        H       H       CH.sub.2 COEt Ga                                     Et        H       H       H             Ga                                     Et        H       H       Me            Ga                                     Et        H       H       Et            Gb                                     Et        H       H       Pr-n          Gb                                     Et        H       H       Pr-i          Gb                                     Et        H       H       Bu-n          Gc                                     Et        Me      H       H             Ga                                     Et        Et      H       H             Gb                                     Et        Me      H       Me            Gb                                     Et        Me      H       Et            Gb                                     Et        H       Me      Me            Ga                                     Et        H       Me      Et            Gb                                     Et        H       H       F             Ga                                     Et        H       H       Cl            Ga                                     Et        H       H       Br            Gb                                     Et        H       H       I             Gb                                     Et        H       H       CF.sub.3      Ga                                     Et        H       H       CH.sub.2 F    Ga                                     Et        H       H       CH.sub.2 Cl   Ga                                     Et        H       H       CH.sub.2 Br   Gb                                     Et        H       H       CH.sub.2 I    Gb                                     Et        H       H       CH.sub.2 CH.sub.2 F                                                                          Ga                                     Et        H       H       CH.sub.2 CH.sub.2 Cl                                                                         Ga                                     Et        H       H       CH.sub.2 CH.sub.2 Br                                                                         Gb                                     Et        H       H       CH.sub.2 CH.sub.2 I                                                                          Gb                                     Et        H       H       CH(CH.sub.3)CH.sub.2 F                                                                       Ga                                     Et        H       H       CH(CH.sub.3)CH.sub.2 Cl                                                                      Ga                                     Et        H       H       CH(CH.sub.3)CH.sub.2 Br                                                                      Gb                                     Et        H       H       CH(CH.sub.3)CH.sub.2 I                                                                       Gb                                     Et        H       H       CH.sub.2 OMe  Ga                                     Et        H       H       CH.sub.2 OEt  Ga                                     Et        H       H       CH.sub.2 CH.sub.2 OMe                                                                        Ga                                     Et        H       H       CH.sub.2 CH.sub.2 OEt                                                                        Ga                                     Et        H       H       CH(CH.sub.3)CH.sub.2 OMe                                                                     Gb                                     Et        H       H       CH(CH.sub.3)CH.sub.2 OEt                                                                     Gb                                     Et        H       H       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     Et        H       H       CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     Et        H       H       CH.sub.2 OCHF.sub.2                                                                          Ga                                     Et        H       H       CH.sub.2 OCF.sub.3                                                                           Ga                                     Et        H       H       CH.sub.2 SMe  Ga                                     Et        H       H       CH.sub.2 SEt  Ga                                     Et        H       H       CH.sub.2 SO.sub.2 Me                                                                         Ga                                     Et        H       H       CH.sub.2 SO.sub.2 Et                                                                         Ga                                     Et        H       H       CH.sub.2 CF.sub.3                                                                            Ga                                     Et        H       H       CH.sub.2 CN   Ga                                     Et        H       H       CO.sub.2 Me   Ga                                     Et        H       H       CO.sub.2 Et   Ga                                     Et        H       H       CO.sub.2 Pr-n Gb                                     Et        H       H       CH.sub.2 CO.sub.2 Me                                                                         Ga                                     Et        H       H       CH.sub.2 CO.sub.2 Et                                                                         Ga                                     Et        H       H       CH.sub.2 CO.sub.2 Pr-n                                                                       Gb                                     Et        H       H       COMe          Ga                                     Et        H       H       COEt          Ga                                     Et        H       H       COPr-n        Gb                                     Et        H       H       CH.sub.2 COMe Ga                                     Et        H       H       CH.sub.2 COEt Ga                                     Pr-n      H       H       H             Ga                                     Pr-n      H       H       Me            Gb                                     Pr-n      H       H       Et            Gb                                     Pr-n      Me      H       H             Ga                                     Pr-n      Et      H       H             Gb                                     Pr-n      Me      H       Me            Gb                                     Pr-n      Me      H       Et            Gb                                     Pr-n      H       Me      Me            Ga                                     Pr-n      H       Me      Et            Gb                                     Pr-n      H       H       CF.sub.3      Ga                                     Pr-n      H       H       CH.sub.2 F    Ga                                     Pr-n      H       H       CH.sub.2 Cl   Ga                                     Pr-n      H       H       CH.sub.2 Br   Gb                                     Pr-n      H       H       CH.sub.2 I    Gb                                     Pr-n      H       H       CH.sub.2 OMe  Ga                                     Pr-n      H       H       CH.sub.2 OEt  Ga                                     Pr-n      H       H       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     Pr-n      H       H       CH.sub.2 OCH.sub.2 C CH                                                                      Ga                                     Pr-n      H       H       CH.sub.2 OCHF.sub.2                                                                          Ga                                     Pr-n      H       H       CH.sub.2 OCF.sub.3                                                                           Ga                                     Pr-n      H       H       CH.sub.2 SMe  Ga                                     Pr-n      H       H       CH.sub.2 SEt  Ga                                     Pr-n      H       H       CH.sub.2 SO.sub.2 Me                                                                         Ga                                     Pr-n      H       H       CH.sub.2 SO.sub.2 Et                                                                         Ga                                     Pr-n      H       H       CH.sub.2 CF.sub.3                                                                            Ga                                     Pr-n      H       H       CH.sub.2 CN   Ga                                     Pr-n      H       H       CO.sub.2 Me   Ga                                     Pr-n      H       H       CO.sub.2 Et   Ga                                     Pr-n      H       H       CH.sub.2 CO.sub.2 Me                                                                         Ga                                     Pr-n      H       H       CH.sub.2 CO.sub.2 Et                                                                         Ga                                     Pr-n      H       H       COMe          Ga                                     Pr-n      H       H       COEt          Ga                                     Pr-n      H       H       CH.sub.2 COMe Ga                                     Pr-n      H       H       CH.sub.2 COEt Ga                                     Pr-i      H       H       H             Ga                                     Pr-i      H       H       Me            Gb                                     Pr-i      H       H       Et            Gb                                     Pr-i      Me      H       H             Ga                                     Pr-i      Et      H       H             Gb                                     Pr-i      Me      H       Me            Gb                                     Pr-i      Me      H       Et            Gb                                     Pr-i      H       Me      Me            Ga                                     Pr-i      H       Me      Et            Gb                                     Pr-i      H       H       CF.sub.3      Ga                                     Pr-i      H       H       CH.sub.2 F    Ga                                     Pr-i      H       H       CH.sub.2 Cl   Ga                                     Pr-i      H       H       CH.sub.2 Br   Gb                                     Pr-i      H       H       CH.sub.2 I    Gb                                     Pr-i      H       H       CH.sub.2 OMe  Ga                                     Pr-i      H       H       CH.sub.2 OEt  Ga                                     Pr-i      H       H       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     Pr-i      H       H       CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     Pr-i      H       H       CH.sub.2 OCHF.sub.2                                                                          Ga                                     Pr-i      H       H       CH.sub.2 OCF.sub.3                                                                           Ga                                     Pr-i      H       H       CH.sub.2 SMe  Ga                                     Pr-i      H       H       CH.sub.2 SEt  Ga                                     Pr-i      H       H       CH.sub.2 SO.sub.2 Me                                                                         Ga                                     Pr-i      H       H       CH.sub.2 SO.sub.2 Et                                                                         Ga                                     Pr-i      H       H       CH.sub.2 CF.sub.3                                                                            Ga                                     Pr-i      H       H       CH.sub.2 CN   Ga                                     Pr-i      H       H       CO.sub.2 Me   Ga                                     Pr-i      H       H       CO.sub.2 Et   Ga                                     Pr-i      H       H       CH.sub.2 CO.sub.2 Me                                                                         Ga                                     Pr-i      H       H       CH.sub.2 CO.sub.2 Et                                                                         Ga                                     Pr-i      H       H       COMe          Ga                                     Pr-i      H       H       COEt          Ga                                     Pr-i      H       H       CH.sub.2 COMe Ga                                     Pr-i      H       H       CH.sub.2 COEt Ga                                     Bu-n      H       H       H             Ga                                     Bu-n      H       H       Me            Gb                                     Bu-n      Me      H       H             Ga                                     Bu-n      Me      H       Me            Gb                                     Bu-n      H       Me      Me            Ga                                     Bu-n      H       H       CF.sub.3      Ga                                     Bu-n      H       H       CH.sub.2 F    Ga                                     Bu-n      H       H       CH.sub.2 Cl   Ga                                     Bu-n      H       H       CH.sub.2 Br   Gb                                     Bu-n      H       H       CH.sub.2 I    Gb                                     Bu-n      H       H       CH.sub.2 OMe  Ga                                     Bu-n      H       H       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     Bu-n      H       H       CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     Bu-n      H       H       CH.sub.2 OCHF.sub.2                                                                          Ga                                     Bu-n      H       H       CH.sub.2 OCF.sub.3                                                                           Ga                                     Bu-n      H       H       CH.sub.2 SMe  Ga                                     Bu-n      H       H       CH.sub.2 SO.sub.2 Me                                                                         Ga                                     Bu-n      H       H       CH.sub.2 CF.sub.3                                                                            Ga                                     Bu-n      H       H       CH.sub.2 CN   Ga                                     Bu-n      H       H       CO.sub.2 Me   Ga                                     Bu-n      H       H       CH.sub.2 CO.sub.2 Me                                                                         Ga                                     Bu-n      H       H       COMe          Ga                                     Bu-n      H       H       CH.sub.2 COMe Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       H             Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       Me            Gb                                     CH.sub.2 CHCH.sub.2                                                                      H       H       Et            Gb                                     CH.sub.2 CHCH.sub.2                                                                      Me      H       H             Ga                                     CH.sub.2 CHCH.sub.2                                                                      Et      H       H             Gb                                     CH.sub.2 CHCH.sub.2                                                                      Me      H       Me            Gb                                     CH.sub.2 CHCH.sub.2                                                                      Me      H       Et            Gb                                     CH.sub.2 CHCH.sub.2                                                                      H       Me      Me            Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       Me      Et            Gb                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CF.sub.3      Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 F    Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 Cl   Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 Br   Gb                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 I    Gb                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 OMe  Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 OEt  Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 SMe  Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 SEt  Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 CN   Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CO.sub.2 Me   Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CO.sub.2 Et   Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       COMe          Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       COEt          Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 COMe Ga                                     CH.sub.2 CHCH.sub.2                                                                      H       H       CH.sub.2 COEt Ga                                     CH.sub.2 CCH                                                                             H       H       H             Ga                                     CH.sub.2 CCH                                                                             H       H       Me            Gb                                     CH.sub.2 CCH                                                                             H       H       Et            Gb                                     CH.sub.2 CCH                                                                             Me      H       H             Ga                                     CH.sub.2 CCH                                                                             Et      H       H             Gb                                     CH.sub.2 CCH                                                                             Me      H       Me            Gb                                     CH.sub.2 CCH                                                                             Me      H       Et            Gb                                     CH.sub.2 CCH                                                                             H       Me      Me            Ga                                     CH.sub.2 CCH                                                                             H       H       F             Ga                                     CH.sub.2 CCH                                                                             H       Me      Et            Gb                                     CH.sub.2 CCH                                                                             H       H       CF.sub.3      Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 F    Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 Cl   Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 Br   Gb                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 I    Gb                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 OMe  Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 OEt  Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 OCH.sub.2 CCH                                                                       Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 OCHF.sub.2                                                                          Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 OCF.sub.3                                                                           Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 SMe  Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 SEt  Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 SO.sub.2 Me                                                                         Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 SO.sub.2 Et                                                                         Ga                                     CH.sub.2 C CH                                                                            H       H       CH.sub.2 CF.sub.3                                                                            Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 CN   Ga                                     CH.sub.2 CCH                                                                             H       H       CO.sub.2 Me   Ga                                     CH.sub.2 CCH                                                                             H       H       CO.sub.2 Et   Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 CO.sub.2 Me                                                                         Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 CO.sub.2 Et                                                                         Ga                                     CH.sub.2 CCH                                                                             H       H       COMe          Ga                                     CH.sub.2 CCH                                                                             H       H       COEt          Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 COMe Ga                                     CH.sub.2 CCH                                                                             H       H       CH.sub.2 COEt Ga                                     ______________________________________                                    

                  TABLE 10                                                         ______________________________________                                          ##STR153##                                                                    R.sup.21  R.sup.25                                                                              R.sup.26                                                                              R.sup.27                                                                            R.sup.28     Gn                                   ______________________________________                                         Me        H      H      H    H            Ga                                   Me        H      H      H    Me           Ga                                   Me        H      H      H    Et           Ga                                   Me        H      H      H    Pr-n         Gb                                   Me        Me     H      H    H            Ga                                   Me        H      Me     H    H            Ga                                   Me        Me     H      H    Me           Gb                                   Me        Me     Me     H    Me           Gb                                   Me        H      H      Me   Me           Gb                                   Me        H      H      H    CF.sub.3     Gb                                   Me        H      H      H    CH.sub.2 F   Gb                                   Me        H      H      H    CH.sub.2 Cl  Gb                                   Me        H      H      H    CH.sub.2 Br  Gb                                   Me        H      H      H    CH.sub.2 I   Gb                                   Me        H      H      H    CH.sub.2 OMe Gb                                   Me        H      H      H    CH.sub.2 OEt Gb                                   Me        H      H      H    CH.sub.2 OCH.sub.2 CHCH.sub.2                                                               Gb                                   Me        H      H      H    CH.sub.2 OCH.sub.2 CCH                                                                      Gb                                   Me        H      H      H    CH.sub.2 SMe Gb                                   Me        H      H      H    CH.sub.2 SO.sub.2 Me                                                                        Gb                                   Me        H      H      H    CH.sub.2 CN  Gb                                   Me        H      H      H    CO.sub.2 Me  Gb                                   Me        H      H      H    CO.sub.2 Et  Gb                                   Me        H      H      H    COMe         Gb                                   Me        H      H      H    COEt         Gb                                   Me        H      H      H    CH.sub.2 CO.sub.2 Me                                                                        Gb                                   Me        H      H      H    CH.sub.2 CO.sub.2 Et                                                                        Gb                                   Me        H      H      H    CH.sub.2 COMe                                                                               Gb                                   Me        H      H      H    CH.sub.2 COEt                                                                               Gb                                   Et        H      H      H    H            Ga                                   Et        H      H      H    Me           Ga                                   Et        H      H      H    Et           Ga                                   Et        H      H      H    Pr-n         Gb                                   Et        Me     H      H    H            Ga                                   Et        H      Me     H    H            Ga                                   Et        Me     H      H    Me           Gb                                   Et        Me     Me     H    Me           Gb                                   Et        H      H      Me   Me           Gb                                   Et        H      H      H    CF.sub.3     Gb                                   Et        H      H      H    CH.sub.2 F   Gb                                   Et        H      H      H    CH.sub.2 Cl  Gb                                   Et        H      H      H    CH.sub.2 Br  Gb                                   Et        H      H      H    CH.sub.2 I   Gb                                   Et        H      H      H    CH.sub.2 OMe Gb                                   Et        H      H      H    CH.sub.2 OEt Gb                                   Et        H      H      H    CH.sub.2 CN  Gb                                   Et        H      H      H    COMe         Gb                                   Et        H      H      H    COEt         Gb                                   Et        H      H      H    CH.sub.2 CO.sub.2 Me                                                                        Gb                                   Et        H      H      H    CH.sub.2 CO.sub.2 Et                                                                        Gb                                   Et        H      H      H    CH.sub.2 COMe                                                                               Gb                                   Et        H      H      H    CH.sub.2 COEt                                                                               Gb                                   Pr-n      H      H      H    H            Ga                                   Pr-n      H      H      H    Me           Ga                                   Pr-n      H      H      H    Et           Ga                                   Pr-n      H      H      H    Pr-n         Gb                                   Pr-n      Me     H      H    H            Ga                                   Pr-n      H      Me     H    H            Ga                                   Pr-n      Me     H      H    Me           Gb                                   Pr-n      Me     Me     H    Me           Gb                                   Pr-n      H      H      Me   Me           Gb                                   Pr-n      H      H      H    CF.sub.3     Gb                                   Pr-n      H      H      H    CH.sub.2 F   Gb                                   Pr-n      H      H      H    CH.sub.2 Cl  Gb                                   Pr-n      H      H      H    CH.sub.2 Br  Gb                                   Pr-n      H      H      H    CH.sub.2 I   Gb                                   Pr-n      H      H      H    CH.sub.2 OMe Gb                                   Pr-n      H      H      H    CH.sub.2 OEt Gb                                   Pr-i      H      H      H    H            Ga                                   Pr-i      H      H      H    Me           Ga                                   Pr-i      H      H      H    Et           Ga                                   Pr-i      H      H      H    Pr-n         Gb                                   Pr-i      Me     H      H    H            Ga                                   Pr-i      H      Me     H    H            Ga                                   Pr-i      Me     H      H    Me           Gb                                   Pr-i      Me     Me     H    Me           Gb                                   Pr-i      H      H      Me   Me           Gb                                   Bu-n      H      H      H    H            Ga                                   Bu-n      H      H      H    Me           Ga                                   Bu-n      H      H      H    Et           Ga                                   Bu-n      H      H      H    Pr-n         Gb                                   CH.sub.2 CHCH.sub.2                                                                      H      H      H    H            Ga                                   CH.sub.2 CHCH.sub.2                                                                      H      H      H    Me           Ga                                   CH.sub.2 CHCH.sub.2                                                                      H      H      H    Et           Ga                                   CH.sub.2 CHCH.sub.2                                                                      H      H      H    Pr-n         Gb                                   CH.sub.2 CHCH.sub.2                                                                      Me     H      H    H            Ga                                   CH.sub.2 CHCH.sub.2                                                                      H      Me     H    H            Ga                                   CH.sub.2 CHCH.sub.2                                                                      Me     H      H    Me           Gb                                   CH.sub.2 CHCH.sub.2                                                                      Me     Me     H    Me           Gb                                   CH.sub.2 CHCH.sub.2                                                                      H      H      Me   Me           Gb                                   CH.sub.2 CCH                                                                             H      H      H    H            Ga                                   CH.sub.2 CCH                                                                             H      H      H    Me           Ga                                   CH.sub.2 CCH                                                                             H      H      H    Et           Ga                                   CH.sub.2 CCH                                                                             H      H      H    Pr-n         Gb                                   CH.sub.2 CCH                                                                             Me     H      H    H            Ga                                   CH.sub.2 CCH                                                                             H      Me     H    H            Ga                                   CH.sub.2 CCH                                                                             Me     H      H    Me           Gb                                   CH.sub.2 CCH                                                                             Me     Me     H    Me           Gb                                   CH.sub.2 CCH                                                                             H      H      Me   Me           Gb                                   ______________________________________                                    

                  TABLE 11                                                         ______________________________________                                          ##STR154##                                                                    R.sup.21  R.sup.22  R.sup.23  R.sup.24                                                                              Gn                                        ______________________________________                                         Me        H         H         H      Gc                                        Me        H         H         Me     Gc                                        Me        H         H         Et     Gc                                        Me        Me        H         H      Gc                                        Me        Et        H         H      Gc                                        Me        Me        H         Me     Gc                                        Me        H         Me        Me     Gc                                        Et        H         H         H      Gc                                        Et        H         H         Me     Gc                                        Et        H         H         Et     Gc                                        Et        Me        H         H      Gc                                        Et        H         Me        Me     Gc                                        ______________________________________                                    

                  TABLE 12                                                         ______________________________________                                          ##STR155##                                                                    R.sup.21 R.sup.25 R.sup.26                                                                               R.sup.27                                                                              R.sup.28                                                                              Gn                                     ______________________________________                                         Me       H        H       H      H      Gc                                     Me       H        H       H      Me     Gc                                     Me       H        H       H      Et     Gc                                     Me       Me       H       H      H      Gc                                     Me       H        Me      H      H      Gc                                     Me       H        H       Me     Me     Gc                                     Me       Me       H       H      Me     Gc                                     Et       H        H       H      H      Gc                                     Et       H        H       Me     Me     Gc                                     Et       Me       H       H      H      Gc                                     Et       H        H       H      Me     Gc                                     ______________________________________                                    

                  TABLE 13                                                         ______________________________________                                          ##STR156##                                                                    R.sup.21  R.sup.22  R.sup.23 R.sup.24                                                                               Gn                                        ______________________________________                                         Me        H         H        H       Gc                                        Me        H         H        Me      Gc                                        Me        H         H        Et      Gc                                        Me        Me        H        H       Gc                                        Me        Et        H        H       Gc                                        Me        Me        H        Me      Gc                                        Me        H         Me       Me      Gc                                        Et        H         H        H       Gc                                        Et        H         H        Me      Gc                                        Et        H         H        Et      Gc                                        Et        Me        H        H       Gc                                        Et        H         Me       Me      Gc                                        ______________________________________                                    

                  TABLE 14                                                         ______________________________________                                          ##STR157##                                                                    R.sup.21                                                                               R.sup.25 R.sup.26 R.sup.27                                                                              R.sup.28                                                                              Gn                                     ______________________________________                                         Me      H        H        H      H      Gc                                     Me      H        H        H      Me     Gc                                     Me      H        H        H      Et     Gc                                     Me      Me       H        H      H      Gc                                     Me      H        Me       H      H      Gc                                     Me      H        H        Me     Me     Gc                                     Me      Me       H        H      Me     Gc                                     Et      H        H        H      H      Gc                                     Et      H        H        H      Me     Gc                                     Et      Me       H        H      H      Gc                                     Et      H        H        Me     Me     Gc                                     ______________________________________                                    

                  TABLE 1A                                                         ______________________________________                                          ##STR158##                                                                    R.sup.11       R.sup.12   R.sup.13                                                                              Gn                                            ______________________________________                                         Me             Me         Me     G.sub.1                                       Me             Me         Me     G.sub.3                                       Me             Me         Me     G.sub.5                                       Me             Me         Me     G.sub.6                                       Me             Me         Me     G.sub.7                                       Me             Me         Me     G.sub.8                                       Me             Me         Me     G.sub.11                                      Me             Me         Me     G.sub.12                                      Me             Me         Me     G.sub.13                                      Me             Me         Me     G.sub.14                                      Me             Me         Me     G.sub.15                                      Me             Me         Me     G.sub.16                                      Me             Me         Me     G.sub.19                                      Me             Me         Me     G.sub.20                                      Me             Me         Me     G.sub.23                                      Me             Me         Me     G.sub.25                                      Me             Me         Me     G.sub.26                                      Me             Me         Me     G.sub.27                                      Me             Me         Me     G.sub.29                                      Me             Me         Me     G.sub.31                                      Me             Me         Me     G.sub.34                                      Me             Me         Me     G.sub.36                                      Me             Me         Me     G.sub.39                                      Me             Me         Me     G.sub.41                                      Me             Me         Me     G.sub.42                                      Me             Me         Me     G.sub.44                                      Me             Me         Me     G.sub.99                                      Me             Me         Me     G.sub.100                                     Me             Me         Me     G.sub.103                                     Me             Me         Me     G.sub.116                                     Me             Me         Me     G.sub. 117                                    Me             Me         Me     G.sub.120                                     Me             Me         Me     G.sub.121                                     Me             Me         Me     G.sub.122                                     Me             Me         Me     G.sub.123                                     Me             Me         Me     G.sub.124                                     Me             Me         Me     G.sub.125                                     Me             Me         Me     G.sub.126                                     Me             Me         Me     G.sub.129                                     Me             Me         Me     G.sub.132                                     Me             Me         Me     G.sub.144                                     Me             Me         Me     G.sub.180                                     Me             Me         Me     G.sub.181                                     Me             Me         Me     G.sub.189                                     Me             Me         Me     G.sub.190                                     Me             Me         Me     G.sub.192                                     Me             Me         Me     G.sub.193                                     Me             Me         Me     G.sub.194                                     Me             Me         Me     G.sub.196                                     Me             Me         Me     G.sub.197                                     Me             Me         Me     G.sub.198                                     Me             Me         Me     G.sub.209                                     Me             Me         Me     G.sub.213                                     Me             Me         Me     G.sub.214                                     Me             Me         Me     G.sub.215                                     Me             Me         Me     G.sub.219                                     Me             Me         Me     G.sub.220                                     Me             Me         Me     G.sub.221                                     Me             Me         Me     G.sub.222                                     Me             Me         Me     G.sub.224                                     Me             Me         Me     G.sub.226                                     Me             Me         Me     G.sub.229                                     Me             Me         Me     G.sub.232                                     Me             Me         Me     G.sub.235                                     Me             Me         Me     G.sub.236                                     Me             Me         Me     G.sub.238                                     Me             Me         Me     G.sub.248                                     Me             Me         Me     G.sub.250                                     Me             Me         Me     G.sub.259                                     Me             Me         Me     G.sub.262                                     Me             Me         Me     G.sub. 265                                    Me             Me         Me     G.sub.267                                     Me             Me         Me     G.sub.268                                     Me             Me         Me     G.sub.269                                     Me             Me         Me     G.sub.270                                     Me             Me         Me     G.sub.271                                     Me             Me         Me     G.sub.272                                     Me             Me         Me     G.sub.273                                     Me             Me         Me     G.sub.274                                     Me             Me         Me     G.sub.275                                     Me             Me         Me     G.sub.276                                     Me             Me         Me     G.sub.277                                     Me             Me         Me     G.sub.278                                     Me             Me         Me     G.sub.280                                     Me             Me         Me     G.sub.283                                     Me             Me         Me     G.sub.286                                     Me             Me         Me     G.sub.289                                     Me             Me         Me     G.sub.292                                     Me             Me         Me     G.sub.295                                     Me             Me         Me     G.sub.296                                     Me             Me         Me     G.sub.298                                     Me             Me         Me     G.sub.299                                     Me             Me         Me     G.sub.301                                     Me             Me         Me     G.sub.302                                     Me             Me         Me     G.sub.304                                     Me             Me         Me     G.sub.305                                     Me             Me         Me     G.sub.309                                     Me             Me         Me     G.sub.310                                     Me             Me         Me     G.sub.311                                     Me             Me         Me     G.sub.316                                     Me             Me         Me     G.sub.317                                     Me             Me         Me     G.sub.319                                     Me             Me         Me     G.sub.320                                     Me             Me         Me     G.sub.328                                     Me             Me         Me     G.sub.329                                     Me             Me         Me     G.sub.334                                     Me             Me         Me     G.sub.335                                     Me             Me         Me     G.sub.343                                     Me             Me         Me     G.sub.344                                     Me             Me         Me     G.sub.346                                     Me             Me         Me     G.sub. 347                                    Me             Me         Me     G.sub.349                                     Me             Me         Me     G.sub.350                                     Me             Me         Me     G.sub.352                                     Me             Me         Me     G.sub.353                                     Me             Me         Me     G.sub.355                                     Me             Me         Me     G.sub.356                                     Me             Me         Me     G.sub.358                                     Me             Me         Me     G.sub.359                                     Me             Me         Me     G.sub.364                                     Me             Me         Me     G.sub.367                                     Me             Me         Me     G.sub.370                                     Me             Me         Me     G.sub.373                                     Me             Me         Me     G.sub.376                                     Me             Me         Me     G.sub.377                                     Me             Me         Me     G.sub.382                                     Me             Me         Me     G.sub.383                                     Me             Me         Me     G.sub.385                                     Me             Me         Me     G.sub.386                                     Me             Me         Me     G.sub.394                                     Me             Me         Me     G.sub.395                                     Me             Me         Me     G.sub.403                                     Me             Me         Me     G.sub.406                                     Me             Me         Me     G.sub.409                                     Me             Me         Me     G.sub.415                                     Me             Me         Me     G.sub.421                                     Me             Me         Me     G.sub.427                                     Me             Me         Me     G.sub.430                                     Me             Me         Me     G.sub.439                                     Me             Me         Me     G.sub.448                                     Me             Me         Me     G.sub.451                                     Me             Me         Me     G.sub.454                                     Me             Me         Me     G.sub.455                                     Me             Me         Me     G.sub.457                                     Me             Me         Me     G.sub.458                                     Me             Me         Me     G.sub.463                                     Me             Me         Me     G.sub.464                                     Me             Me         Me     G.sub.469                                     Me             Me         Me     G.sub.472                                     Me             Me         Me     G.sub.475                                     Me             Me         Me     G.sub. 478                                    Me             Me         Me     G.sub.484                                     Me             Me         Me     G.sub.498                                     Me             Me         Me     G.sub.499                                     Me             Me         Me     G.sub.500                                     Me             Me         Me     G.sub.501                                     Me             Me         Me     G.sub.503                                     Me             Me         Me     G.sub.504                                     Me             Me         Me     G.sub.505                                     Me             Me         Me     G.sub.506                                     Me             Me         Me     G.sub.507                                     Me             Me         Me     G.sub.508                                     Me             Me         Me     G.sub.509                                     Me             Me         Me     G.sub.510                                     Me             Me         Me     G.sub.511                                     Me             Me         Me     G.sub.512                                     Me             Me         Me     G.sub.513                                     Me             Me         Me     G.sub.514                                     Me             Me         Me     G.sub.515                                     Me             Me         Me     G.sub.537                                     Me             Me         Me     G.sub.538                                     Me             Me         Me     G.sub.539                                     Me             Me         Me     G.sub.543                                     Me             Me         Me     G.sub.544                                     Me             Me         Me     G.sub.545                                     Me             Me         Me     G.sub.549                                     Me             Me         Me     G.sub.550                                     Me             Me         Me     G.sub.551                                     Me             Me         Me     G.sub.555                                     Me             Me         Me     G.sub.556                                     Me             Me         Me     G.sub.557                                     Me             Me         Me     G.sub.561                                     Me             Me         Me     G.sub.562                                     Me             Me         Me     G.sub.563                                     Me             Me         Me     G.sub.567                                     Me             Me         Me     G.sub.568                                     Me             Me         Me     G.sub.569                                     Me             Me         Me     G.sub.573                                     Me             Me         Me     G.sub.574                                     Me             Me         Me     G.sub.575                                     Me             Me         Me     G.sub. 579                                    Me             Me         Me     G.sub.580                                     Me             Me         Me     G.sub.581                                     Me             Me         Me     G.sub.585                                     Me             Me         Me     G.sub.586                                     Me             Me         Me     G.sub.587                                     Me             Me         Me     G.sub.593                                     Me             Me         Me     G.sub.598                                     Me             Me         Me     G.sub.599                                     Me             Me         Me     G.sub.601                                     Me             Me         Me     G.sub.606                                     Me             Me         Me     G.sub.608                                     Me             Me         Me     G.sub.610                                     Me             Me         Me     G.sub.611                                     Me             Me         Me     G.sub.612                                     Me             Me         Me     G.sub.613                                     Me             Me         Me     G.sub.614                                     Me             Me         Me     G.sub.615                                     Me             Me         Me     G.sub.617                                     Me             Me         Me     G.sub.618                                     Me             Me         Me     G.sub.620                                     Me             Me         Me     G.sub.621                                     Me             Me         Me     G.sub.622                                     Me             Me         Me     G.sub.626                                     Me             Me         Me     G.sub.627                                     Me             Me         Me     G.sub.628                                     Me             Me         Me     G.sub.632                                     Me             Me         Me     G.sub.633                                     Me             Me         Me     G.sub.634                                     Me             Me         Me     G.sub.638                                     Me             Me         Me     G.sub.639                                     Me             Me         Me     G.sub.640                                     Me             Me         Me     G.sub.643                                     Me             Me         Et     G.sub.3                                       Me             Me         Et     G.sub.6                                       Me             Me         Et     G.sub.268                                     Me             Me         Et     G.sub.269                                     Me             Me         Et     G.sub.271                                     Me             Me         Et     G.sub.272                                     Me             Me         Et     G.sub.274                                     Me             Me         Et     G.sub. 275                                    Me             Me         Et     G.sub.277                                     Me             Me         Et     G.sub.278                                     Me             Me         Et     G.sub.355                                     Me             Me         Ph     G.sub.3                                       Me             Me         Ph     G.sub.6                                       Me             Et         Et     G.sub.3                                       Me             Et         Et     G.sub.6                                       Me             (CH.sub.2).sub.4                                                                             G.sub.3                                           Me             (CH.sub.2).sub.4                                                                             G.sub.6                                           Me             (CH.sub.2).sub.5                                                                             G.sub.3                                           Me             (CH.sub.2).sub.5                                                                             G.sub.6                                           Et             Me         Me     G.sub.3                                       Et             Me         Me     G.sub.6                                       Et             Me         Me     G.sub.268                                     Et             Me         Me     G.sub.269                                     Et             Me         Me     G.sub.271                                     Et             Me         Me     G.sub.272                                     Et             Me         Me     G.sub.274                                     Et             Me         Me     G.sub.275                                     Et             Me         Me     G.sub.277                                     Et             Me         Me     G.sub.278                                     Et             Me         Me     G.sub.355                                     Et             Me         Et     G.sub.3                                       Et             Me         Et     G.sub.6                                       Et             Me         Ph     G.sub.3                                       Et             Me         Ph     G.sub.6                                       Et             Et         Et     G.sub.3                                       Et             Et         Et     G.sub.6                                       Et             (CH.sub.2).sub.4                                                                             G.sub.3                                           Et             (CH.sub.2).sub.4                                                                             G.sub.6                                           Et             (CH.sub.2).sub.5                                                                             G.sub.3                                           Et             (CH.sub.2).sub.5                                                                             G.sub.6                                           Pr-n           Me         Me     G.sub.3                                       Pr-n           Me         Me     G.sub.6                                       Pr-i           Me         Me     G.sub.3                                       Pr-i           Me         Me     G.sub.6                                       cyc-Pr         Me         Me     G.sub.3                                       cyc-Pr         Me         Me     G.sub.6                                       cyc-Pr         Me         Me     G.sub.268                                     cyc-Pr         Me         Me     G.sub.269                                     cyc-Pr         Me         Me     G.sub.271                                     cyc-Pr         Me         Me     G.sub.272                                     cyc-Pr         Me         Me     G.sub.274                                     cyc-Pr         Me         Me     G.sub.275                                     cyc-Pr         Me         Me     G.sub.277                                     cyc-Pr         Me         Me     G.sub.278                                     cyc-Pr         Me         Me     G.sub.355                                     cyc-PrCH.sub.2 Me         Me     G.sub.3                                       cyc-PrCH.sub.2 Me         Me     G.sub.6                                       Bu-n           Me         Me     G.sub.3                                       Bu-n           Me         Me     G.sub.6                                       Bu-sec         Me         Me     G.sub.3                                       Bu-sec         Me         Me     G.sub.6                                       Bu-i           Me         Me     G.sub.3                                       Bu-i           Me         Me     G.sub.6                                       cyc-Bu         Me         Me     G.sub.3                                       cyc-Bu         Me         Me     G.sub.6                                       Bu-t           Me         Me     G.sub.3                                       Bu-t           Me         Me     G.sub.6                                       CH.sub.2CHCH.sub.2                                                                            Me         Me     G.sub.3                                       CH.sub.2CHCH.sub.2                                                                            Me         Me     G.sub.6                                       CHCCH.sub.2    Me         Me     G.sub.3                                       CHCCH.sub.2    Me         Me     G.sub.6                                       cyc-Pen        Me         Me     G.sub.3                                       cyc-Pen        Me         Me     G.sub.6                                       cyc-Hex        Me         Me     G.sub.3                                       cyc-Hex        Me         Me     G.sub.6                                       MeOCH.sub.2 CH.sub.2                                                                          Me         Me     G.sub.3                                       MeOCH.sub.2 CH.sub.2                                                                          Me         Me     G.sub.6                                       MeOCH.sub.2 (CH.sub.3)CH                                                                      Me         Me     G.sub.3                                       MeOCH.sub.2 (CH.sub.3)CH                                                                      Me         Me     G.sub.6                                       CHF.sub.2 OCH.sub.2                                                                           Me         Me     G.sub.3                                       CHF.sub.2 OCH.sub.2                                                                           Me         Me     G.sub.6                                       FCH.sub.2      Me         Me     G.sub.3                                       FCH.sub.2      Me         Me     G.sub.6                                       FCH.sub.2 CH.sub.2                                                                            Me         Me     G.sub.3                                       FCH.sub.2 CH.sub.2                                                                            Me         Me     G.sub.6                                       ClCH.sub.2 CH.sub.2                                                                           Me         Me     G.sub.3                                       ClCH.sub.2 CH.sub.2                                                                           Me         Me     G.sub.6                                       CF.sub.3 CH.sub.2                                                                             Me         Me     G.sub.3                                       CF.sub.3 CH.sub.2                                                                             Me         Me     G.sub.6                                       NCCH.sub.2     Me         Me     G.sub.3                                       NCCH.sub.2     Me         Me     G.sub.6                                       MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.3                                       MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.6                                       MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.268                                     MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.269                                     MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.271                                     MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.272                                     MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.274                                     MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.275                                     MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.277                                     MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.278                                     MeO.sub.2 CCH.sub.2                                                                           Me         Me     G.sub.355                                     MeCOCH.sub.2   Me         Me     G.sub.3                                       MeCOCH.sub.2   Me         Me     G.sub.6                                       PhCH.sub.2     Me         Me     G.sub.3                                       PhCH.sub.2     Me         Me     G.sub.6                                       Ph             Me         Me     G.sub.3                                       Ph             Me         Me     G.sub.6                                       Ph             Me         Me     G.sub.268                                     Ph             Me         Me     G.sub.269                                     Ph             Me         Me     G.sub.271                                     Ph             Me         Me     G.sub.272                                     Ph             Me         Me     G.sub.274                                     Ph             Me         Me     G.sub.275                                     Ph             Me         Me     G.sub.277                                     Ph             Me         Me     G.sub.278                                     Ph             Me         Me     G.sub.355                                     Ph-2-Me        Me         Me     G.sub.3                                       Ph-2-Me        Me         Me     G.sub.6                                       Ph-3-Me        Me         Me     G.sub.3                                       Ph-3-Me        Me         Me     G.sub.6                                       Ph-4-OMe       Me         Me     G.sub.3                                       Ph-4-OMe       Me         Me     G.sub.6                                       Ph-3-OMe       Me         Me     G.sub.3                                       Ph-3-OMe       Me         Me     G.sub.6                                       Ph-2-OMe       Me         Me     G.sub.3                                       Ph-2-OMe       Me         Me     G.sub.6                                       Ph-4-Cl        Me         Me     G.sub.3                                       Ph-4-Cl        Me         Me     G.sub.6                                       Ph-3-Cl        Me         Me     G.sub.3                                       Ph-3-Cl        Me         Me     G.sub.6                                       Ph-2-Cl        Me         Me     G.sub.3                                       Ph-2-Cl        Me         Me     G.sub.6                                       Ph-2,6-Cl.sub.2                                                                               Me         Me     G.sub.3                                       Ph-2,6-Cl.sub.2                                                                               Me         Me     G.sub.6                                       ______________________________________                                    

                  TABLE 2A                                                         ______________________________________                                          ##STR159##                                                                    R.sup.11        R.sup.12 R.sup.13  Gn                                          ______________________________________                                         Me              Me       Me        G.sub.3                                     Me              Me       Me        G.sub.6                                     Me              Me       Me        G.sub.268                                   Me              Me       Me        G.sub.269                                   Me              Me       Me        G.sub.271                                   Me              Me       Me        G.sub.272                                   Me              Me       Me        G.sub.274                                   Me              Me       Me        G.sub.275                                   Me              Me       Me        G.sub.277                                   Me              Me       Me        G.sub.278                                   Me              Me       Me        G.sub.355                                   Me              Me       Et        G.sub.3                                     Me              Me       Et        G.sub.6                                     Me              Me       Ph        G.sub.3                                     Me              Me       Ph        G.sub.6                                     Et              Me       Me        G.sub.3                                     Et              Me       Me        G.sub.6                                     Et              Me       Me        G.sub.268                                   Et              Me       Me        G.sub.269                                   Et              Me       Me        G.sub.271                                   Et              Me       Me        G.sub.272                                   Et              Me       Me        G.sub.274                                   Et              Me       Me        G.sub.275                                   Et              Me       Me        G.sub.277                                   Et              Me       Me        G.sub.278                                   Et              Me       Me        G.sub.355                                   Pr-n            Me       Me        G.sub.3                                     Pr-n            Me       Me        G.sub.6                                     Pr-i            Me       Me        G.sub.3                                     Pr-i            Me       Me        G.sub.6                                     CH.sub.2CHCH.sub.2                                                                             Me       Me        G.sub.3                                     CH.sub.2CHCH.sub.2                                                                             Me       Me        G.sub.6                                     CHCCH.sub.2     Me       Me        G.sub.3                                     CHCCH.sub.2     Me       Me        G.sub.6                                     MeOCH.sub.2     Me       Me        G.sub.3                                     MeOCH.sub.2     Me       Me        G.sub.6                                     MeSCH.sub.2     Me       Me        G.sub.3                                     MeSCH.sub.2     Me       Me        G.sub.6                                     MeO.sub.2 CCH.sub.2                                                                            Me       Me        G.sub.3                                     MeO.sub.2 CCH.sub.2                                                                            Me       Me        G.sub.6                                     Ph              Me       Me        G.sub.3                                     Ph              Me       Me        G.sub.6                                     PhCH.sub.2      Me       Me        G.sub.3                                     PhCH.sub.2      Me       Me        G.sub.6                                     ______________________________________                                    

                  TABLE 3A                                                         ______________________________________                                          ##STR160##                                                                    R.sup.11     R.sup.12   R.sup.13  Gn                                           ______________________________________                                         Me           Me         Me        G.sub.3                                      Me           Me         Me        G.sub.6                                      Me           Me         Me        G.sub.268                                    Me           Me         Me        G.sub.269                                    Me           Me         Me        G.sub.271                                    Me           Me         Me        G.sub.272                                    Me           Me         Me        G.sub.274                                    Me           Me         Me        G.sub.275                                    Me           Me         Me        G.sub.277                                    Me           Me         Me        G.sub.278                                    Me           Me         Me        G.sub.355                                    Et           Me         Me        G.sub.3                                      Et           Me         Me        G.sub.6                                      Pr-n         Me         Me        G.sub.3                                      Pr-n         Me         Me        G.sub.6                                      cyc-Pr       Me         Me        G.sub.3                                      cyc-Pr       Me         Me        G.sub.6                                      Me           Me         Et        G.sub.3                                      Me           Me         Et        G.sub.6                                      Me           Et         Me        G.sub.3                                      Me           Et         Me        G.sub.6                                      Me             (CH.sub.2).sub.3                                                                              G.sub.3                                          Me             (CH.sub.2).sub.3                                                                              G.sub.6                                          Me             (CH.sub.2).sub.4                                                                              G.sub.3                                          Me             (CH.sub.2).sub.4                                                                              G.sub.6                                          ______________________________________                                    

                  TABLE 4A                                                         ______________________________________                                          ##STR161##                                                                    R.sup.11        R.sup.12 R.sup.13  Gn                                          ______________________________________                                         Me              Me       Me        G.sub.3                                     Me              Me       Me        G.sub.6                                     Me              Me       Et        G.sub.3                                     Me              Me       Et        G.sub.6                                     Et              Me       Me        G.sub.3                                     Et              Me       Me        G.sub.6                                     Pr-n            Me       Me        G.sub.3                                     Pr-n            Me       Me        G.sub.6                                     CH.sub.2CHCH.sub.2                                                                             Me       Me        G.sub.3                                     CH.sub.2CHCH.sub.2                                                                             Me       Me        G.sub.6                                     CHCCH.sub.2     Me       Me        G.sub.3                                     CHCCH.sub.2     Me       Me        G.sub.6                                     ______________________________________                                    

                  TABLE 5A                                                         ______________________________________                                          ##STR162##                                                                    R.sup.11        R.sup.12 R.sup.13  Gn                                          ______________________________________                                         Me              Me       Me        G.sub.3                                     Me              Me       Me        G.sub.6                                     Me              Me       Et        G.sub.3                                     Me              Me       Et        G.sub.6                                     Et              Me       Me        G.sub.3                                     Et              Me       Me        G.sub.6                                     Pr-n            Me       Me        G.sub.3                                     Pr-n            Me       Me        G.sub.6                                     CH.sub.2CHCH.sub.2                                                                             Me       Me        G.sub.3                                     CH.sub.2CHCH.sub.2                                                                             Me       Me        G.sub.6                                     ______________________________________                                    

                  TABLE 6A                                                         ______________________________________                                          ##STR163##                                                                    R.sup.11       R.sup.12  R.sup.13  Gn                                          ______________________________________                                         Me             Me        Me        G.sub.3                                     Me             Me        Me        G.sub.6                                     Et             Me        Me        G.sub.3                                     Et             Me        Me        G.sub.6                                     cyc-Pr         Me        Me        G.sub.3                                     cyc-Pr         Me        Me        G.sub.6                                     CH.sub.2CHCH.sub.2                                                                            Me        Me        G.sub.3                                     CH.sub.2CHCH.sub.2                                                                            Me        Me        G.sub.6                                     CHCCH.sub.2    Me        Me        G.sub.3                                     CHCCH.sub.2    Me        Me        G.sub.6                                     Me             Me        Et        G.sub.3                                     Me             Me        Et        G.sub.6                                     Me             Et        Me        G.sub.3                                     Me             Et        Me        G.sub.6                                     ______________________________________                                    

                  TABLE 7A                                                         ______________________________________                                          ##STR164##                                                                    R.sup.21      R.sup.22                                                                               R.sup.23 R.sup.24                                                                              Gn                                       ______________________________________                                         H             H       H        H      G.sub.3                                  H             H       H        H      G.sub.6                                  Me            H       H        H      G.sub.3                                  Me            H       H        H      G.sub.6                                  Me            H       H        H      G.sub.268                                Me            H       H        H      G.sub.269                                Me            H       H        H      G.sub.271                                Me            H       H        H      G.sub.272                                Me            H       H        H      G.sub.274                                Me            H       H        H      G.sub.275                                Me            H       H        H      G.sub.277                                Me            H       H        H      G.sub.278                                Me            H       H        H      G.sub.355                                Me            H       H        Me     G.sub.3                                  Me            H       H        Me     G.sub.6                                  Me            H       H        Me     G.sub.268                                Me            H       H        Me     G.sub.269                                Me            H       H        Me     G.sub.271                                Me            H       H        Me     G.sub.272                                Me            H       H        Me     G.sub.274                                Me            H       H        Me     G.sub.275                                Me            H       H        Me     G.sub.277                                Me            H       H        Me     G.sub.278                                Me            H       H        Me     G.sub.355                                Me            H       H        Et     G.sub.3                                  Me            H       H        Et     G.sub.6                                  Me            H       Me       Me     G.sub.3                                  Me            H       Me       Me     G.sub.6                                  Et            H       H        H      G.sub.3                                  Et            H       H        H      G.sub.6                                  Et            H       H        H      G.sub.268                                Et            H       H        H      G.sub.269                                Et            H       H        H      G.sub.271                                Et            H       H        H      G.sub.272                                Et            H       H        H      G.sub.274                                Et            H       H        H      G.sub.275                                Et            H       H        H      G.sub.277                                Et            H       H        H      G.sub.278                                Et            H       H        H      G.sub.355                                Pr-n          H       H        H      G.sub.3                                  Pr-n          H       H        H      G.sub.6                                  Pr-i          H       H        H      G.sub.3                                  Pr-i          H       H        H      G.sub.6                                  Bu-n          H       H        H      G.sub.3                                  Bu-n          H       H        H      G.sub.6                                  Bu-t          H       H        H      G.sub.3                                  Bu-t          H       H        H      G.sub.6                                  CH.sub.2CHCH.sub.2                                                                           H       H        H      G.sub.3                                  CH.sub.2CHCH.sub.2                                                                           H       H        H      G.sub.6                                  CHCCH.sub.2   H       H        H      G.sub.3                                  CH CCH.sub.2  H       H        H      G.sub.6                                  MeOCH.sub.2   H       H        H      G.sub.3                                  MeOCH.sub.2   H       H        H      G.sub.6                                  MeO.sub.2 CCH.sub.2                                                                          H       H        H      G.sub.3                                  MeO.sub.2 CCH.sub.2                                                                          H       H        H      G.sub.6                                  ______________________________________                                    

                  TABLE 8A                                                         ______________________________________                                          ##STR165##                                                                    R.sup.21     R.sup.25                                                                               R.sup.26                                                                               R.sup.27                                                                             R.sup.28                                                                             Gn                                    ______________________________________                                         Me           H       H       H     H     G.sub.1                               Me           H       H       H     H     G.sub.3                               Me           H       H       H     H     G.sub.5                               Me           H       H       H     H     G.sub.6                               Me           H       H       H     H     G.sub.7                               Me           H       H       H     H     G.sub.8                               Me           H       H       H     H     G.sub.11                              Me           H       H       H     H     G.sub.12                              Me           H       H       H     H     G.sub.13                              Me           H       H       H     H     G.sub.14                              Me           H       H       H     H     G.sub.15                              Me           H       H       H     H     G.sub.16                              Me           H       H       H     H     G.sub.19                              Me           H       H       H     H     G.sub.20                              Me           H       H       H     H     G.sub.23                              Me           H       H       H     H     G.sub.25                              Me           H       H       H     H     G.sub.26                              Me           H       H       H     H     G.sub.27                              Me           H       H       H     H     G.sub.29                              Me           H       H       H     H     G.sub.31                              Me           H       H       H     H     G.sub.34                              Me           H       H       H     H     G.sub.36                              Me           H       H       H     H     G.sub.39                              Me           H       H       H     H     G.sub.41                              Me           H       H       H     H     G.sub.42                              Me           H       H       H     H     G.sub.44                              Me           H       H       H     H     G.sub.99                              Me           H       H       H     H     G.sub.100                             Me           H       H       H     H     G.sub.103                             Me           H       H       H     H     G.sub.116                             Me           H       H       H     H     G.sub.117                             Me           H       H       H     H     G.sub.120                             Me           H       H       H     H     G.sub.121                             Me           H       H       H     H     G.sub.122                             Me           H       H       H     H     G.sub.123                             Me           H       H       H     H     G.sub.124                             Me           H       H       H     H     G.sub.125                             Me           H       H       H     H     G.sub.126                             Me           H       H       H     H     G.sub.129                             Me           H       H       H     H     G.sub.132                             Me           H       H       H     H     G.sub.144                             Me           H       H       H     H     G.sub.180                             Me           H       H       H     H     G.sub.181                             Me           H       H       H     H     G.sub.189                             Me           H       H       H     H     G.sub.190                             Me           H       H       H     H     G.sub.192                             Me           H       H       H     H     G.sub. 193                            Me           H       H       H     H     G.sub.194                             Me           H       H       H     H     G.sub.196                             Me           H       H       H     H     G.sub.197                             Me           H       H       H     H     G.sub.198                             Me           H       H       H     H     G.sub.209                             Me           H       H       H     H     G.sub.213                             Me           H       H       H     H     G.sub.214                             Me           H       H       H     H     G.sub.215                             Me           H       H       H     H     G.sub.219                             Me           H       H       H     H     G.sub.220                             Me           H       H       H     H     G.sub.221                             Me           H       H       H     H     G.sub.222                             Me           H       H       H     H     G.sub.224                             Me           H       H       H     H     G.sub.226                             Me           H       H       H     H     G.sub.229                             Me           H       H       H     H     G.sub.232                             Me           H       H       H     H     G.sub.235                             Me           H       H       H     H     G.sub.236                             Me           H       H       H     H     G.sub.238                             Me           H       H       H     H     G.sub.248                             Me           H       H       H     H     G.sub.250                             Me           H       H       H     H     G.sub.259                             Me           H       H       H     H     G.sub.262                             Me           H       H       H     H     G.sub.265                             Me           H       H       H     H     G.sub.267                             Me           H       H       H     H     C.sub.268                             Me           H       H       H     H     C.sub.269                             Me           H       H       H     H     G.sub.270                             Me           H       H       H     H     G.sub.271                             Me           H       H       H     H     G.sub.272                             Me           H       H       H     H     G.sub.273                             Me           H       H       H     H     G.sub.274                             Me           H       H       H     H     G.sub.275                             Me           H       H       H     H     G.sub.276                             Me           H       H       H     H     G.sub.277                             Me           H       H       H     H     G.sub.278                             Me           H       H       H     H     G.sub.280                             Me           H       H       H     H     G.sub.283                             Me           H       H       H     H     G.sub.286                             Me           H       H       H     H     G.sub.289                             Me           H       H       H     H     G.sub.292                             Me           H       H       H     H     G.sub.295                             Me           H       H       H     H     G.sub.296                             Me           H       H       H     H     G.sub.298                             Me           H       H       H     H     G.sub.299                             Me           H       H       H     H     G.sub.301                             Me           H       H       H     H     G.sub.302                             Me           H       H       H     H     G.sub.304                             Me           H       H       H     H     G.sub.305                             Me           H       H       H     H     G.sub.309                             Me           H       H       H     H     G.sub.310                             Me           H       H       H     H     G.sub.311                             Me           H       H       H     H     G.sub.316                             Me           H       H       H     H     G.sub.317                             Me           H       H       H     H     G.sub.320                             Me           H       H       H     H     G.sub.328                             Me           H       H       H     H     G.sub.329                             Me           H       H       H     H     G.sub.334                             Me           H       H       H     H     G.sub.335                             Me           H       H       H     H     G.sub.343                             Me           H       H       H     H     G.sub.344                             Me           H       H       H     H     G.sub.346                             Me           H       H       H     H     G.sub.347                             Me           H       H       H     H     G.sub.349                             Me           H       H       H     H     G.sub.350                             Me           H       H       H     H     G.sub.352                             Me           H       H       H     H     G.sub.353                             Me           H       H       H     H     G.sub.355                             Me           H       H       H     H     G.sub.356                             Me           H       H       H     H     G.sub.358                             Me           H       H       H     H     G.sub.359                             Me           H       H       H     H     G.sub.364                             Me           H       H       H     H     G.sub.367                             Me           H       H       H     H     G.sub.370                             Me           H       H       H     H     G.sub.373                             Me           H       H       H     H     G.sub.376                             Me           H       H       H     H     G.sub.377                             Me           H       H       H     H     G.sub.382                             Me           H       H       H     H     G.sub.383                             Me           H       H       H     H     G.sub.385                             Me           H       H       H     H     G.sub.386                             Me           H       H       H     H     G.sub.394                             Me           H       H       H     H     G.sub.395                             Me           H       H       H     H     G.sub.403                             Me           H       H       H     H     G.sub.406                             Me           H       H       H     H     G.sub.409                             Me           H       H       H     H     G.sub.415                             Me           H       H       H     H     G.sub.421                             Me           H       H       H     H     G.sub.427                             Me           H       H       H     H     G.sub.430                             Me           H       H       H     H     G.sub.439                             Me           H       H       H     H     G.sub.448                             Me           H       H       H     H     G.sub.451                             Me           H       H       H     H     G.sub.454                             Me           H       H       H     H     G.sub.455                             Me           H       H       H     H     G.sub.457                             Me           H       H       H     H     G.sub.458                             Me           H       H       H     H     G.sub.463                             Me           H       H       H     H     G.sub.464                             Me           H       H       H     H     G.sub.469                             Me           H       H       H     H     G.sub.472                             Me           H       H       H     H     G.sub.475                             Me           H       H       H     H     G.sub.478                             Me           H       H       H     H     G.sub.484                             Me           H       H       H     H     G.sub.498                             Me           H       H       H     H     G.sub.499                             Me           H       H       H     H     G.sub.500                             Me           H       H       H     H     G.sub.501                             Me           H       H       H     H     G.sub.503                             Me           H       H       H     H     G.sub.504                             Me           H       H       H     H     G.sub.505                             Me           H       H       H     H     G.sub.506                             Me           H       H       H     H     G.sub.507                             Me           H       H       H     H     G.sub.508                             Me           H       H       H     H     G.sub.509                             Me           H       H       H     H     G.sub.510                             Me           H       H       H     H     G.sub.511                             Me           H       H       H     H     G.sub.512                             Me           H       H       H     H     G.sub.513                             Me           H       H       H     H     G.sub.514                             Me           H       H       H     H     G.sub.515                             Me           H       H       H     H     G.sub.537                             Me           H       H       H     H     G.sub.538                             Me           H       H       H     H     G.sub.539                             Me           H       H       H     H     G.sub.543                             Me           H       H       H     H     G.sub.544                             Me           H       H       H     H     G.sub.545                             Me           H       H       H     H     G.sub.549                             Me           H       H       H     H     G.sub.550                             Me           H       H       H     H     G.sub.551                             Me           H       H       H     H     G.sub.555                             Me           H       H       H     H     G.sub.556                             Me           H       H       H     H     G.sub.557                             Me           H       H       H     H     G.sub.561                             Me           H       H       H     H     G.sub.562                             Me           H       H       H     H     G.sub.563                             Me           H       H       H     H     G.sub.567                             Me           H       H       H     H     G.sub.568                             Me           H       H       H     H     G.sub.569                             Me           H       H       H     H     G.sub.573                             Me           H       H       H     H     G.sub.574                             Me           H       H       H     H     G.sub.575                             Me           H       H       H     H     G.sub.579                             Me           H       H       H     H     G.sub.580                             Me           H       H       H     H     G.sub.581                             Me           H       H       H     H     G.sub.585                             Me           H       H       H     H     G.sub.586                             Me           H       H       H     H     G.sub.587                             Me           H       H       H     H     G.sub.593                             Me           H       H       H     H     G.sub.598                             Me           H       H       H     H     G.sub.599                             Me           H       H       H     H     G.sub.601                             Me           H       H       H     H     G.sub.606                             Me           H       H       H     H     G.sub.608                             Me           H       H       H     H     G.sub.610                             Me           H       H       H     H     G.sub.611                             Me           H       H       H     H     G.sub.612                             Me           H       H       H     H     G.sub.613                             Me           H       H       H     H     G.sub.614                             Me           H       H       H     H     G.sub.615                             Me           H       H       H     H     G.sub.617                             Me           H       H       H     H     G.sub.618                             Me           H       H       H     H     G.sub.620                             Me           H       H       H     H     G.sub.621                             Me           H       H       H     H     G.sub.622                             Me           H       H       H     H     G.sub.626                             Me           H       H       H     H     G.sub.627                             Me           H       H       H     H     G.sub.628                             Me           H       H       H     H     G.sub.632                             Me           H       H       H     H     G.sub.633                             Me           H       H       H     H     G.sub.634                             Me           H       H       H     H     G.sub.638                             Me           H       H       H     H     G.sub.639                             Me           H       H       H     H     G.sub.640                             Me           H       H       H     H     G.sub.643                             Me           H       H       H     Me    G.sub.3                               Me           H       H       H     Me    G.sub.6                               Me           H       H       H     Me    G.sub.268                             Me           H       H       H     Me    G.sub.269                             Me           H       H       H     Me    G.sub.271                             Me           H       H       H     Me    G.sub.272                             Me           H       H       H     Me    G.sub.274                             Me           H       H       H     Me    G.sub.275                             Me           H       H       H     Me    G.sub.277                             Me           H       H       H     Me    G.sub.278                             Me           H       H       H     Me    G.sub.355                             Me           Me      H       H     H     G.sub.3                               Me           Me      H       H     H     G.sub.6                               Et           H       H       H     H     G.sub.3                               Et           H       H       H     H     G.sub.6                               Et           H       H       H     H     G.sub.268                             Et           H       H       H     H     G.sub.269                             Et           H       H       H     H     G.sub.271                             Et           H       H       H     H     G.sub.272                             Et           H       H       H     H     G.sub.274                             Et           H       H       H     H     G.sub.275                             Et           H       H       H     H     G.sub.277                             Et           H       H       H     H     G.sub.278                             Et           H       H       H     H     G.sub. 355                            Pr-n         H       H       H     H     G.sub.3                               Pr-n         H       H       H     H     G.sub.6                               CH.sub.2CHCH.sub.2                                                                          H       H       H     H     G.sub.3                               CH.sub.2CHCH.sub.2                                                                          H       H       H     H     G.sub.6                               CH CCH.sub.2 H       H       H     H     G.sub.3                               CH CCH.sub.2 H       H       H     H     G.sub.6                               ______________________________________                                    

                  TABLE 9A                                                         ______________________________________                                          ##STR166##                                                                    R.sup.21      R.sup.22                                                                               R.sup.23 R.sup.24                                                                              Gn                                       ______________________________________                                         Me            H       H        H      G.sub.3                                  Me            H       H        H      G.sub.6                                  Me            H       H        H      G.sub.268                                Me            H       H        H      G.sub.269                                Me            H       H        H      G.sub.271                                Me            H       H        H      G.sub.272                                Me            H       H        H      G.sub.274                                Me            H       H        H      G.sub.275                                Me            H       H        H      G.sub.277                                Me            H       H        H      G.sub.278                                Me            H       H        H      G.sub.355                                Me            H       H        Me     G.sub.3                                  Me            H       H        Me     G.sub.6                                  Et            H       H        H      G.sub.3                                  Et            H       H        H      G.sub.6                                  CH.sub.2CHCH.sub.2                                                                           H       H        H      G.sub.3                                  CH.sub.2CHCH.sub.2                                                                           H       H        H      G.sub.6                                  CHCCH.sub.2   H       H        H      G.sub.3                                  CHCCH.sub.2   H       H        H      G.sub.6                                  ______________________________________                                    

                  TABLE 10A                                                        ______________________________________                                          ##STR167##                                                                    R.sup.21    R.sup.25                                                                               R.sup.26                                                                               R.sup.27                                                                             R.sup.28                                                                             Gn                                     ______________________________________                                         Me          H       H       H     H     G.sub.3                                Me          H       H       H     H     G.sub.6                                Me          H       H       H     H     G.sub.268                              Me          H       H       H     H     G.sub.269                              Me          H       H       H     H     G.sub.271                              Me          H       H       H     H     G.sub.272                              Me          H       H       H     H     G.sub.274                              Me          H       H       H     H     G.sub.275                              Me          H       H       H     H     G.sub.277                              Me          H       H       H     H     G.sub.278                              Me          H       H       H     H     G.sub.355                              Et          H       H       H     H     G.sub.3                                Et          H       H       H     H     G.sub.6                                CH.sub.2CHCH.sub.2                                                                         H       H       H     H     G.sub.3                                CH.sub.2CHCH.sub.2                                                                         H       H       H     H     G.sub.6                                CH CCH.sub.2                                                                               H       H       H     H     G.sub.3                                CHCCH.sub.2 H       H       H     H     G.sub.6                                ______________________________________                                    

                  TABLE 11A                                                        ______________________________________                                          ##STR168##                                                                    R.sup.21  R.sup.22 R.sup.23  R.sup.24                                                                               Gn                                        ______________________________________                                         Me        H        H         H       G.sub.3                                   Me        H        H         H       G.sub.6                                   Me        H        H         Me      G.sub.3                                   Me        H        H         Me      G.sub.6                                   ______________________________________                                    

                  TABLE 12A                                                        ______________________________________                                          ##STR169##                                                                    R.sup.21                                                                               R.sup.25 R.sup.26 R.sup.27                                                                              R.sup.28                                                                              Gn                                     ______________________________________                                         Me      H        H        H      H      G.sub.3                                Me      H        H        H      H      G.sub.6                                Et      H        H        H      H      G.sub.3                                Et      H        H        H      H      G.sub.6                                ______________________________________                                    

                  TABLE 13A                                                        ______________________________________                                          ##STR170##                                                                    R.sup.21  R.sup.22 R.sup.23  R.sup.24                                                                               Gn                                        ______________________________________                                         Me        H        H         H       G.sub.3                                   Me        H        H         H       G.sub.6                                   Me        H        H         Me      G.sub.3                                   Me        H        H         Me      G.sub.6                                   ______________________________________                                    

                  TABLE 14A                                                        ______________________________________                                          ##STR171##                                                                    R.sup.21                                                                               R.sup.25 R.sup.26 R.sup.27                                                                              R.sup.28                                                                              Gn                                     ______________________________________                                         Me      H        H        H      H      G.sub.3                                Me      H        H        H      H      G.sub.6                                Et      H        H        H      H      G.sub.3                                Et      H        H        H      H      G.sub.6                                ______________________________________                                    

The compound of the present invention can be applied to control various weeds not only in the agricultural and horticultural fields such as upland fields, paddy fields or orchards, but also in non-agricultural fields such as play grounds, non-used vacant fields or railway sides.

The dose varies depending upon the application site, the season for application, the manner of application, the type of weeds to be controlled, the type of crop plants, etc. However, the dose is usually within a range of from 0.0001 to 10 kg per hectare, preferably from 0.005 to 5 kg per hectare, as the amount of the active ingredient.

Further, the compound of the present invention may be combined with other herbicides, various insecticides, fungicides, plant growth regulating agents and synergism agents at the time of the preparation of the formulations or at the time of the application, as the case requires.

Particularly, by the combined application with other herbicide, it can be expected to reduce the cost due to a decrease of the dose or to enlarge the herbicidal spectrum or obtain higher herbicidal effects due to a synergistic effect of the combined herbicides. In such a case, the compound of the present invention may be combined with a plurality of known herbicides. The herbicides of the type which can be used in combination with the compound of the present invention, may, for example, be compounds disclosed in Farm Chemicals Handbook (1990).

When the compound of the present invention is to be used as a herbicide, it is usually mixed with a suitable carrier, for instance, a solid carrier such as clay, talc, bentonite, diatomaceous earth or fine silica powder, or a liquid carrier such as water, an alcohol (such as isopropanol, butanol, benzyl alcohol or furfuryl alcohol), an aromatic hydrocarbon (such as toluene or xylene), an ether (such as anisole), a ketone (such as cyclohexanone or isophorone), an ester (such as butyl acetate), an acid amide (such as N-methylpyrrolidone), or a halogenated hydrocarbon (such as chlorobenzene). If desired, a surfactant, an emulsifier, a dispersing agent, a penetrating agent, a spreader, a thickener, an antifreezing agent, a coagulation preventing agent or a stabilizer may be added to prepare an optional formulation such as a liquid formulation, an emulsifiable concentrate, a wettable powder, a dry flowable, a flowable, a dust or a granule.

Now, Formulation Examples of the herbicides containing the compounds of the present invention as active ingredients, will be given. However, it should be understood that the present invention is by no means restricted to such specific Examples. In the following Formulation Examples, "parts" means "parts by weight".

    ______________________________________                                         Wettable powder                                                                ______________________________________                                         Compound of the present invention                                                                   5-80 parts                                                Solid carrier        10-85 parts                                               Surfactant           1-10 parts                                                Other                1-5 parts                                                 ______________________________________                                    

As other, a coagulation preventing agent may, for example, be mentioned.

    ______________________________________                                         Emulsifiable concentrate                                                       Compound of the present invention                                                                   1-30 parts                                                Liquid carrier       30-95 parts                                               Surfactant           5-15 parts                                                Flowable                                                                       Compound of the present invention                                                                   5-70 parts                                                Liquid carrier       15-65 parts                                               Surfactant           5-12 parts                                                Other                5-30 parts                                                ______________________________________                                    

As other, an antifreezing agent and a thickener may, for example, be mentioned.

    ______________________________________                                         Granular wettable powder (dry flowable)                                        Compound of the present invention                                                                      20-90 parts                                            Solid carrier           10-60 parts                                            Surfactant              1-20 parts                                              Granule                                                                       Compound of the present invention                                                                      0.1-10 parts                                           Solid carrier           90-99.99 parts                                         Other                   1-5 parts                                              ______________________________________                                    

FORMULATION EXAMPLE 1 Wettable powder

    ______________________________________                                         Compound No. 2 of the present invention                                                                 20 parts                                              Zeeklite A (tradename for a kaolin-type                                                                 76 parts                                              clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                               2 parts                                               nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Industry Co., Ltd.)                                                            Carplex (tradename for a coagulation-                                                                   2 parts                                               preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder.

FORMULATION EXAMPLE 2 Wettable powder

    ______________________________________                                         Compound No. 3 of the present invention                                                                 40 parts                                              Zeeklite A (tradename for a kaolin-type                                                                 54 parts                                              clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                               2 parts                                               nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Industry Co., Ltd.)                                                            Carplex (tradename for a coagulation-                                                                   4 parts                                               preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder.

FORMULATION EXAMPLE 3 Emulsifiable concentrate

    ______________________________________                                         Compound No. 5 of the present invention                                                                 5 parts                                               Xylene                   75 parts                                              N,N-dimethylformamide    15 parts                                              Sorpol 2680 (tradename for a mixture of a                                                               5 parts                                               nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Industry Co., Ltd.)                                                            ______________________________________                                    

The above ingredients are homogeneously mixed to form an emulsifiable concentrate.

FORMULATION EXAMPLE 4 Flowable

    ______________________________________                                         Compound No. 6 of the present invention                                                                   25     parts                                        Agrizole S-710 (tradename for a nonionic                                                                  10     parts                                        surfactant, manufactured by Kao Corp.)                                         Runox 1000C (tradename for an anionic                                                                     0.5    part                                         surfactant, manufactured by Toho Chemical                                      Industry Co., Ltd.)                                                            1% Rodopol water (tradename for a thickener,                                                              20     parts                                        manufactured by Rhone-Poulenc)                                                 Water                      44.5   parts                                        ______________________________________                                    

The above ingredients were homogeneously mixed to obtain a flowable.

FORMULATION EXAMPLE 5 Flowable

    ______________________________________                                         Compound No. 11 of the present invention                                                                  40     parts                                        Agrizole S-710 (tradename for a nonionic                                                                  10     parts                                        surfactant, manufactured by Kao Corp.)                                         Runox 1000C (tradename for an anionic                                                                     0.5    part                                         surfactant, manufactured by Toho Chemical                                      Industry Co., Ltd.)                                                            1% Rodopol water (tradename for a thickener,                                                              20     parts                                        manufactured by Rhone-Poulenc)                                                 Water                      29.5   parts                                        ______________________________________                                    

The above ingredients were homogeneously mixed to obtain a flowable.

FORMULATION EXAMPLE 6 Granular wettable powder (dry flowable)

    ______________________________________                                         Compound No. 12 of the present invention                                                                  75     parts                                        Isoban No. 1 (tradename for an anionic                                                                    10     parts                                        surfactant, manufactured by Kuraray Isoprene                                   Chemical Co., Ltd.)                                                            Vanirex N (tradename for an anionic                                                                       5      parts                                        surfactant, manufactured by Sanyo Kokusaku                                     Pulp Co., Ltd.)                                                                Carplex #80 (tradename for fine silica powder,                                                            10     parts                                        manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are uniformly mixed and pulverized to form a dry flowable.

FORMULATION EXAMPLE 7 Granule

    ______________________________________                                         Compound No. 13 of the present invention                                                               1      part                                            Bentonite               55     parts                                           Talc                    44     parts                                           ______________________________________                                    

The above ingredients were homogeneously mixed and pulverized, and after an addition of a small amount of water, the mixture was stirred, mixed and granulated by an extrusion-type granulating machine, followed by drying to obtain a granule.

FORMULATION EXAMPLE 8 Wettable powder

    ______________________________________                                         Compound No. 14 of the present invention                                                                20 parts                                              Zeeklite A (tradename for a kaolin-type                                                                 76 parts                                              clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                               2 parts                                               nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Industry Co., Ltd.)                                                            Carplex (tradename for a coagulation-                                                                   2 parts                                               preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder.

FORMULATION EXAMPLE 9 Wettable powder

    ______________________________________                                         Compound No. 15 of the present invention                                                               40 parts                                               Zeeklite A (tradename for a kaolin-type                                                                54 parts                                               clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                              2 parts                                                nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Industry Co., Ltd.)                                                            Carplex (tradename for a coagulation-                                                                  4 parts                                                preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder.

FORMULATION EXAMPLE 10 Emulsifiable concentrate

    ______________________________________                                         Compound No. 31 of the present invention                                                                5 parts                                               Xylene                   75 parts                                              N,N-dimethylformamide    15 parts                                              Sorpol 2680 (tradename for a mixture of a                                                               5 parts                                               nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Industry Co., Ltd.)                                                            ______________________________________                                    

The above ingredients are homogeneously mixed to form an emulsifiable concentrate.

FORMULATION EXAMPLE 11 Flowable

    ______________________________________                                         Compound No. 35 of the present invention                                                                  25     parts                                        Agrizole S-710 (tradename for a nonionic                                                                  10     parts                                        surfactant, manufactured by Kao Corp.)                                         Runox 1000C (tradename for an anionic                                                                     0.5    part                                         surfactant, manufactured by Toho Chemical                                      Industry Co., Ltd.)                                                            1% Rodopol water (tradename for a thickener,                                                              20     parts                                        manufactured by Rhone-Poulenc)                                                 Water                      44.5   parts                                        ______________________________________                                    

The above ingredients were homogeneously mixed to obtain a flowable.

FORMULATION EXAMPLE 12 Flowable

    ______________________________________                                         Compound No. 42 of the present invention                                                                  40     parts                                        Agrizole S-710 (tradename for a nonionic                                                                  10     parts                                        surfactant, manufactured by Kao Corp.)                                         Runox 1000C (tradename for an anionic                                                                     0.5    part                                         surfactant, manufactured by Toho Chemical                                      Industry Co., Ltd.)                                                            1% Rodopol water (tradename for a thickener,                                                              20     parts                                        manufactured by Rhone-Poulenc)                                                 Water                      44.5   parts                                        ______________________________________                                    

The above ingredients were homogeneously mixed to obtain a flowable.

FORMULATION EXAMPLE 13 Granular wettable powder (dry flowable)

    ______________________________________                                         Compound No. 47 of the present invention                                                                  75 parts                                            Isoban No. 1 (tradename for an anionic                                                                    10 parts                                            surfactant, manufactured by Kuraray Isoprene                                   Chemical Co., Ltd.)                                                            Vanirex N (tradename for an anionic                                                                       5 parts                                             surfactnt, manufactured by Sanyo Kokusaku                                      Pulp Co., Ltd.)                                                                Carplex #80 (tradename for fine silica powder,                                                            10 parts                                            manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are uniformly mixed and pulverized to form a dry flowable.

FORMULATION EXAMPLE 14 Granule

    ______________________________________                                         Compound No. 53 of the present invention                                                                1      part                                           Bentonite                55     parts                                          Talc                     44     parts                                          ______________________________________                                    

The above ingredients were homogeneously mixed and pulverized, and after an addition of a small amount of water, the mixture was stirred, mixed and granulated by an extrusion-type granulating machine, followed by drying to obtain a granule.

In use, the above wettable powder, emulsifiable concentrate, flowable or granular wettable powder is diluted with water from 50 to 1,000 times and applied so that the active ingredient will be from 0.0001 to 10 kg per hectare.

Now, the herbicidal activities of the compounds of the present invention will be described in detail with reference to the following Test Examples.

TEST EXAMPLE 1 Test on the herbicidal effects in soil treatment

A plastic box having a length of 15 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvial soil, and seeds of Echinochloa crus-galli, Digitaria adscendens, Cyperus microiria, Solanum nigrum, Galinsoga ciliata, Rorippa indica, orvza sativa, Zea mays, Triticum aestivum, Glycine max and Gossypium herbaceum were sown, and the soil was covered thereon, and then a herbicide solution was applied by a small spray onto the surface of the soil uniformly so that the active ingredient was distributed at a predetermined concentration. The herbicide solution was prepared by diluting the formulation as described in the foregoing Formulation Examples with water and applied onto the entire soil surface. Three weeks after the application of the herbicidal solution, the herbicidal effects against each weed and the phytotoxicities against each crop plant were determined on the basis of the following standard ratings. The results are shown in Table 15.

Standard ratinqs:

5: Growth control rate of more than 90% (almost completely withered)

4: Growth control rate of from 70 to 90%

3: Growth control rate of from 40 to 70%

2: Growth control rate of from 20 to 40%

1: Growth control rate of from 5 to 20%

0: Growth control rate of less than 5% (almost non-effective)

The above growth control rates were calculated by the following equation: ##EQU1## where T: Weight of the weed grown above the soil surface of the treated area

N: Weight of the weed grown above the soil surface of the non-treated area

TEST EXAMPLE 2 Test on the herbicidal effects in foliage treatment

A plastic box having a length of 15 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvial soil, and seeds of Echinochloa crus-galli, Digitaria adscendens, Cyperus microiria, Solanum nigrum, Galinsoga ciliata, Rorippa indica, oryza sativa, Zea mays, Triticum aestivum, Glycine max, Gossypium herbaceum and Beta vulgaris were spot-wisely sown. When the various weeds and crop plants grew to the 2 or 3 leaf stage, a herbicidal solution was uniformly sprayed on the foliages so that the active ingredient was applied in a predetermined concentration.

The herbicidal solution was prepared by diluting the formulation as described in the above Formulation Examples with water and applied onto the entire surface of the foliages of the weeds and the crop plants by a small spray. Three weeks after the application of the herbicide solution, the herbicidal effects against each weed and the phytotoxicities against each crop plant were determined on the basis of the standard ratings described in Test Example 1. The results are shown in Table 16.

In each Table, Compound Nos. correspond to Compound Nos. in the Examples, and symbols have the following meanings.

Dose: Dose of active ingredient (kg/ha)

N: Echinochloa crus-galli (barnyardgrass)

M: Digitaria adscendens (large crabgrass)

K: Cyperus microiria (annual sedge)

H: Solanum nigrum (black nightshade)

D: Galinsoga ciliata (hairy galinsoga)

I Rorippa indica (fieldcress)

R: Oryza sativa (rice)

T: Zea mays (corn)

S: Glycine max (soybean)

C: Gossypium herbaceum (cotton)

B: Beta vulgaris (sugar beet)

                  TABLE 15                                                         ______________________________________                                         Comp. Dose                                                                                                  No. (kg/ha) N M K H D I R T W S C                 ______________________________________                                          1    0.16     1     2   2   4   5   5   0   0   0   3                                                      2                                                                               0.32 2 3 3 5 5 5 0 0 0 4 3                                                     0.63 3 4 4 5 5 5 2 1 1 5 4                                                     2 0.16 2 3 3 5 5 5 3 0 0 2 3                                                   0.32 4 4 4 5 5 5 4 1 1 3 4                                                     0.63 5 5 5 5 5 5 5 2 4 4 5                                                     3 0.16 2 2 2 5 5 5 0 0 0 2 2                                                   0.32 3 4 4 5 5 5 1 0 1 3 3                                                     0.63 4 5 5 5 5 5 3 1 3 4 4                                                     4 0.16 1 1 1 4 5 5 1 0 0 1 1                                                   0.32 2 2 2 5 5 5 2 0 0 2 2                                                     0.63 3 3 3 5 5 5 4 1 1 3 4                                                     5 0.16 3 3 3 5 5 5 0 0 0 2 2                                                   0.32 4 3 4 5 5 5 1 1 1 3 3                                                     0.63 5 4 5 5 5 5 2 3 3 4 4                                                     6 0.16 2 2 1 5 5 5 3 0 0 2 3                                                   0.32 4 4 2 5 5 5 4 0 1 3 4                                                     0.63 5 5 3 5 5 5 5 2 4 4 5                                                     7 0.63 3 4 4 5 5 5 3 0 0 2 2                                                   8 0.16 1 2 2 4 5 5 3 0 0 2 2                                                   0.32 2 2 2 5 5 5 4 0 0 3 3                                                     0.63 3 3 3 5 5 5 5 1 2 3 4                                                     9 0.16 0 0 0 3 5 5 0 0 0 0 0                                                   0.32 1 1 1 4 5 5 0 0 0 1 1                                                     0.63 2 2 3 5 5 5 0 0 0 2 2                                                    10 0.16 0 1 0 3 5 5 0 0 0 1 0                                                   0.32 1 2 1 4 5 5 1 0 0 2 1                                                     0.63 2 3 2 5 5 5 2 0 0 3 3                                                    11 0.16 4 4 4 5 5 5 0 0 0 3 3                                                   0.32 5 5 4 5 5 5 1 0 0 4 3                                                     0.63 5 5 5 5 5 5 4 0 1 4 4                                                    14 0.04 1 2 1 5 5 5 2 0 0 0 0                                                   0.08 2 4 2 5 5 5 3 0 0 1 1                                                     0.16 3 5 4 5 5 5 3 1 2 4 2                                                    15 0.04 1 2 1 4 5 5 0 0 0 1 0                                                   0.08 2 3 2 5 5 5 0 0 0 2 1                                                     0.16 3 4 3 5 5 5 0 0 0 2 3                                                    16 0.63 1 3 3 4 5 5 1 0 0 1 0                                                  17 0.63 3 4 3 5 5 5 0 0 0 4 2                                                  19 0.16 0 1 1 5 4 5 0 0 0 0 0                                                   0.32 1 1 2 5 5 5 0 0 0 1 1                                                     0.63 2 3 3 5 5 5 0 0 0 2 2                                                    20 0.16 2 1 1 5 4 5 0 0 0 2 1                                                   0.32 3 1 2 5 5 5 0 0 0 3 2                                                     0.63 4 2 3 5 5 5 2 0 0 4 4                                                    21 0.16 3 3 4 5 5 5 2 0 1 2 2                                                   0.32 4 4 5 5 5 5 3 0 2 3 3                                                     0.63 5 5 5 5 5 5 4 1 3 4 4                                                    22 0.16 2 3 4 5 5 5 4 0 4 0 2                                                   0.32 4 4 5 5 5 5 5 1 5 1 3                                                     0.63 5 5 5 5 5 5 5 2 5 3 4                                                    23 0.63 1 2 3 5 5 5 0 0 0 0 2                                                  27 0.63 2 3 2 5 5 5 3 0 3 4 3                                                  28 0.63 2 3 3 5 5 5 2 0 4 4 4                                                  32 0.63 1 2 1 5 5 5 0 0 1 2 1                                                  33 0.16 1 1 0 5 5 4 0 0 0 3 0                                                   0.32 3 4 1 5 5 5 2 0 1 4 1                                                     0.63 5 5 3 5 5 5 4 1 3 5 2                                                    34 0.63 1 2 2 4 5 5 3 0 1 4 4                                                  35 0.63 1 2 1 4 5 5 0 1 0 3 3                                                  42 0.63 3 4 3 5 5 5 5 3 3 4 3                                                  43 0.16 2 3 3 4 5 5 3 0 0 1 2                                                   0.32 3 4 3 5 5 5 4 1 0 2 3                                                     0.63 4 4 4 5 5 5 4 2 0 4 4                                                    47 0.63 4 5 3 4 5 4 4 1 1 0 0                                                  48 0.16 0 1 2 4 4 5 0 0 0 1 1                                                   0.32 1 2 3 5 5 5 0 0 0 2 2                                                     0.63 2 4 4 5 5 5 1 0 0 3 2                                                    49 0.16 2 4 1 4 5 5 3 0 2 2 3                                                   0.32 3 5 2 5 5 5 4 0 3 3 3                                                     0.63 4 5 3 5 5 5 5 1 4 4 4                                                    52 0.16 2 3 2 5 5 5 4 0 2 4 4                                                   0.32 3 4 3 5 5 5 5 1 3 5 5                                                     0.63 3 4 3 5 5 5 5 2 3 5 5                                                    53 0.16 2 4 2 5 5 5 5 0 4 5 4                                                   0.32 4 5 3 5 5 5 5 1 5 5 5                                                     0.63 5 5 4 5 5 5 5 3 5 5 5                                                    55 0.16 1 1 2 4 5 5 2 0 0 0 0                                                   0.32 2 3 3 5 5 5 3 0 1 1 1                                                     0.63 4 5 4 5 5 5 4 0 3 4 3                       ______________________________________                                    

                  TABLE 16                                                         ______________________________________                                               Dose                                                                                                Comp.                                                                              (kg/                                                                       No. ha) N M K H D I R T W S C B                     ______________________________________                                          1    0.16   1     0   0   5   5   5   0   0   0   5                                                      5   5                                                                              0.32 2 1 1 5 5 5 0 0 0 5 5 5                                                   0.63 3 2 3 5 5 5 1 1 1 5 5 5                                                2  0.16 3 1 1 5 5 5 2 0 0 4 5 5                                                   0.32 4 2 2 5 5 5 3 0 0 5 5 5                                                   0.63 5 3 3 5 5 5 4 1 1 5 5 5                                                3  0.16 3 1 1 5 5 5 0 0 0 4 3 5                                                   0.32 4 2 2 5 5 5 0 0 0 5 4 5                                                   0.63 5 3 3 5 5 5 1 1 1 5 5 5                                                4  0.16 2 1 1 5 5 5 0 0 0 4 4 5                                                   0.32 2 2 2 5 5 5 1 0 0 5 5 5                                                   0.63 3 3 3 5 5 5 3 1 1 5 5 5                                                5  0.16 3 1 1 5 5 5 2 0 0 3 4 5                                                   0.32 4 2 2 5 5 5 3 1 0 4 5 5                                                   0.63 5 4 3 5 5 5 4 2 2 5 5 5                                                6  0.16 3 2 1 5 5 5 2 0 0 3 4 5                                                   0.32 4 3 2 5 5 5 3 1 0 4 5 5                                                   0.63 5 4 3 5 5 5 4 2 1 4 5 5                                                7  0.63 2 1 2 5 5 5 1 0 0 4 3 5                                                8  0.16 2 1 1 5 5 5 2 0 0 2 3 4                                                   0.32 3 2 2 5 5 5 2 0 0 3 4 5                                                   0.63 5 3 3 5 5 5 3 1 0 4 4 5                                                9  0.16 0 0 0 5 5 5 0 0 0 4 2 4                                                   0.32 1 1 1 5 5 5 0 0 0 5 3 5                                                   0.63 3 2 2 5 5 5 0 1 0 5 4 5                                               10  0.16 1 0 0 5 5 5 0 0 0 5 2 4                                                   0.32 2 1 1 5 5 5 0 0 0 5 3 5                                                   0.63 4 2 2 5 5 5 0 0 0 5 4 5                                               11  0.16 3 2 2 5 5 5 1 0 0 4 4 5                                                   0.32 4 3 3 5 5 5 2 0 0 5 5 5                                                   0.63 5 4 3 5 5 5 3 1 1 5 5 5                                               14  0.04 0 0 0 5 5 5 0 0 0 2 2 5                                                   0.08 1 1 1 5 5 5 1 0 0 3 4 5                                                   0.16 2 1 2 5 5 5 2 0 0 5 5 5                                               15  0.04 1 1 0 5 5 5 0 0 0 4 3 5                                                   0.08 2 2 1 5 5 5 0 0 0 5 4 5                                                   0.16 3 3 2 5 5 5 0 0 0 5 5 5                                               16  0.16 0 0 0 5 5 5 0 0 0 2 1 4                                                   0.32 1 1 1 5 5 5 0 0 0 3 2 5                                                   0.63 2 2 2 5 5 5 0 0 0 4 3 5                                               17  0.16 1 0 1 5 5 5 0 0 0 5 3 3                                                   0.32 1 1 1 5 5 5 0 0 0 5 4 4                                                   0.63 2 2 2 5 5 5 0 0 0 5 5 5                                               18  0.63 2 1 2 5 5 5 0 0 0 4 2 2                                               19  0.16 1 0 1 5 5 5 0 0 0 2 2 4                                                   0.32 1 1 1 5 5 5 0 0 0 3 3 5                                                   0.63 2 2 2 5 5 5 1 1 0 4 4 5                                               20  0.16 0 0 1 5 5 4 0 0 0 4 3 4                                                   0.32 1 1 1 5 5 5 0 0 0 4 4 5                                                   0.63 2 2 2 5 5 5 1 1 0 5 5 5                                               21  0.16 1 1 1 5 5 5 2 0 0 5 4 5                                                   0.32 2 2 1 5 5 5 2 0 0 5 5 5                                                   0.63 3 3 2 5 5 5 3 1 0 5 5 5                                               22  0.16 1 1 1 5 5 5 1 0 0 1 5 5                                                   0.32 2 2 2 5 5 5 2 0 0 2 5 5                                                   0.63 3 4 3 5 5 5 3 1 1 3 5 5                                               23  0.16 0 0 1 5 5 5 0 0 0 1 2 2                                                   0.32 1 1 2 5 5 5 0 0 0 2 3 3                                                   0.63 2 2 3 5 5 5 0 0 0 3 4 3                                               24  0.16 0 0 0 5 5 5 0 0 0 2 3 4                                                   0.32 1 1 1 5 5 5 0 0 0 2 4 4                                                   0.63 1 2 2 5 5 5 0 0 0 3 5 5                                               26  0.63 3 2 2 4 5 5 3 0 0 5 3 4                                               27  0.16 2 2 0 5 5 5 2 0 0 5 2 5                                                   0.32 3 2 1 5 5 5 3 0 1 5 3 5                                                   0.63 3 3 2 5 5 5 4 1 2 5 3 5                                               28  0.16 1 1 1 5 5 5 0 0 0 5 2 5                                                   0.32 2 2 2 5 5 5 1 0 1 5 3 5                                                   0.63 3 3 3 5 5 5 2 1 3 5 4 5                                               29  0.63 2 1 1 4 5 5 2 2 1 5 2 5                                               31  0.16 0 0 0 4 5 5 0 0 0 4 3 3                                                   0.32 1 1 1 5 5 5 0 0 0 5 4 5                                                   0.63 2 2 2 5 5 5 1 0 0 5 5 5                                               32  0.16 0 0 0 5 5 5 0 0 0 4 2 4                                                   0.32 1 1 1 5 5 5 0 0 0 5 2 5                                                   0.63 3 2 2 5 5 5 1 1 1 5 3 5                                               33  0.04 0 0 0 5 5 5 0 0 0 5 1 3                                                   0.08 1 1 1 5 5 5 0 0 0 5 2 4                                                   0.16 2 2 3 5 5 5 1 1 0 5 2 4                                               34  0.04 0 0 0 4 5 5 0 0 0 4 2 2                                                   0.08 0 0 0 5 5 5 0 0 0 5 3 3                                                   0.16 1 1 1 5 5 5 0 0 1 5 4 5                                               35  0.16 1 1 0 5 5 5 0 0 0 5 2 4                                                   0.32 2 2 1 5 5 5 0 1 0 5 3 5                                                   0.63 3 3 2 5 5 5 2 2 1 5 4 5                                               36  0.16 0 0 0 3 4 5 0 0 0 4 0 1                                                   0.32 1 1 0 5 5 5 0 0 0 4 0 2                                                   0.63 2 2 1 5 5 5 0 0 0 5 1 3                                               37  0.04 0 0 0 4 5 5 0 0 0 4 1 3                                                   0.08 0 0 0 5 5 5 0 0 0 5 2 3                                                   0.16 1 1 1 5 5 5 0 0 0 5 2 4                                               38  0.63 3 2 1 5 5 5 1 1 2 4 3 4                                               42  0.16 0 0 0 5 5 5 1 0 0 4 3 4                                                   0.32 1 1 1 5 5 5 2 1 0 5 4 5                                                   0.63 2 3 2 5 5 5 3 3 0 5 5 5                                               43  0.04 0 0 0 5 5 5 0 0 0 4 3 4                                                   0.08 0 0 0 5 5 5 1 0 0 5 4 5                                                   0.16 1 1 1 5 5 5 2 0 0 5 4 5                                               47  0.04 0 0 0 5 5 5 0 0 0 4 3 1                                                   0.08 1 1 1 5 5 5 0 0 0 5 4 2                                                   0.16 2 2 2 5 5 5 1 0 0 5 4 4                                               48  0.16 0 0 1 5 5 5 0 0 0 3 4 5                                                   0.32 1 1 2 5 5 5 0 0 0 4 5 5                                                   0.63 2 3 3 5 5 5 1 0 0 5 5 5                                               49  0.16 2 1 0 5 5 5 0 0 0 5 5 5                                                   0.32 3 2 1 5 5 5 0 0 0 5 5 5                                                   0.63 4 3 2 5 5 5 1 1 1 5 5 5                                               50  0.63 2 2 1 5 5 5 1 0 0 2 3 4                                               52  0.16 3 1 1 5 5 5 3 1 0 5 5 5                                                   0.32 4 2 2 5 5 5 4 2 1 5 5 5                                                   0.63 5 3 3 5 5 5 4 3 2 5 5 5                                               53  0.16 4 3 2 5 5 5 2 1 0 5 5 5                                                   0.32 5 4 3 5 5 5 3 2 1 5 5 5                                                   0.63 5 5 4 5 5 5 4 4 3 5 5 5                                               55  0.16 2 1 1 4 5 5 0 0 0 3 2 3                                                   0.32 3 2 2 5 5 5 1 0 0 4 3 4                                                   0.63 4 3 4 5 5 5 2 0 1 5 4 4                    ______________________________________                                     

We claim:
 1. A sulfamidosulfonamide derivative of the formula (1) and an agriculturally suitable salt thereof: ##STR172## Wherein Q is ##STR173## whereinR¹¹ is a hydrogen atom, a C₁₋₆ alkyl group, a C₃₋₇ cycloalkyl group, a C₁₋₆ alkyl group substituted by a C₃₋₇ cycloalkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ mono- or poly-halogenoalkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylthio group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylsulfonyl group, a C₁₋₆ mono- or polyhalogenoalkyl group, a C₁₋₆ alkyl group substituted by a cyano group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylcarbonyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a nitro group, a C₁₋₆ alkyl group, a C.sub. 1-6 alkoxy group and a C₁₋₆ alkoxycarbonyl group);R¹² is a hydrogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group and a C₁₋₆ alkoxycarbonyl group); R¹³ is a hydrogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group and a nitro group); or, R¹² and R¹³ form, together with the nitrogen atom to which they are bonded, a saturated 5-7-membered heterocyclic group; or, R¹² and R¹³ form, together With the oxygen atom and the nitrogen atom to which they are bonded, a saturated 5-7-membered heterocyclic group; R²¹ ; is a hydrogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ mono- or poly-halogenoalkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylthio group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylsulfonyl group, a C₁₋₆ mono- or poly-halogenoalkyl group, a C₁₋₆ alkyl group Substituted by a cyano group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylcarbonyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group and a nitro group); R²² is a hydrogen atom or a C₁₋₆ alkyl group; R²³ is a hydrogen atom or a C₁₋₆ alkyl group; R²⁴ is a hydrogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a halogen atom, a C₁₋₆ mono- or poly-halogenoalkyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxy group, a C₁₋₆ alkyl group substituted by a C₂₋₆ alkenyloxy group, a C₁₋₆ alkyl group substituted by a C₂₋₆ alkynyloxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ mono- or poly-halogenoalkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylthio group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylsulfonyl group, a C₁₋₆ alkyl group substituted by a cyano group, a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkylcarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylcarbonyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group and a nitro group); R²⁵ is a hydrogen atom or a C₁₋₆ alkyl group; R²⁶ is a hydrogen atom or a C₁₋₆ alkyl group; R²⁷ is a hydrogen atom or a C₁₋₆ alkyl group; R²⁸ is a hydrogen atom, a halogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₆ mono- or poly-halogenoalkyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxy group, a C₁₋₆ alkyl group substituted by a C₂₋₆ alkenyloxy group, a C₁₋₆ alkyl group substituted by a C₂₋₆ alkynyloxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylthio group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylsulfonyl group, a C₁₋₆ alkyl group substituted by a cyano group, a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkylcarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylcarbonyl group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group and a nitro group); X is an oxygen atom or a sulfur atom; G is ##STR174## wherein each of a, b, c and d, which are independent from one another, is a hydrogen atom, a C₁₋₆ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₆ alkyl group mono- or poly-substituted by a halogen atom, a C₁₋₆ alkoxy group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylthio group, a C₁₋₆ alkyl group substituted by a C₁₋₆ alkylsulfonyl group, a C₁₋₆ alkylthio group, a C₁₋₆ alkylcarbonyl group, a C₃₋₇ cycloalkyl group, a C₃₋₇ cycloalkenyl group, a cyano group, a nitro group, a phenyl group or a benzyl group (provided that such a phenyl group or a benzyl group may be substituted by one or more substituents selected from the group consisting of a halogen atom, a trifluoromethyl group, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkoxycarbonyl group and a nitro group), a 5- or 6-membered heterocyclic group (provided that such a heterocyclic group contains from 1 to 3 hetero atoms selected from the group consisting of nitrogen atoms, oxygen atoms and sulfur atoms in the ring, or contains a sulfonyl group, and such a heterocyclic group may be substituted by one or more substituents selected from the group consisting of a C₁₋₆ alkyl group, a C.sub. 1-6 alkoxy group, a halogen atom, a trifluoromethyl group, a nitro group and a C₁₋₆ alkoxycarbonyl group), a naphthyl group, a benzene-condensed heterocyclic group (provided that such a benzene-condensed heterocyclic group contains 1 or 2 hetero atoms selected from the group consisting of nitrogen atoms, oxygen atoms and sulfur atoms, and such a benzene-condensed heterocyclic group may be substituted by one or more substituents selected from the group consisting of a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a halogen atom, a trifluoromethyl group, a nitro group and a C₁₋₆ alkoxycarbonyl group).
 2. A selective herbicide containing one or more compounds defined in claim 1 as active ingredients.
 3. A herbicidal composition comprising a herbicidally effective amount of one or more compounds defined in claim 1 and an agricultural adjuvant.
 4. A herbicidal composition comprising a herbicidally effective amount of one or more compounds of formula I ##STR175## wherein Y is a member selected from the group consisting of phenyl, substituted phenyl which may be substituted with F, Cl, or OCH₃, and thienyl,Z is hydrogen or methyl, Q' is ##STR176## and an agricultural adjuvant
 5. A herbicidal composition comprising a herbicidally effective amount of one or more compounds of formula I as defined in claim 4, wherein Q' is ##STR177## and an agricultural adjuvant.
 6. A herbicidal composition comprising a herbicidally effective amount of one or more compounds of formula I as defined in claim 4, wherein Q' is ##STR178## and an agricultural adjuvant.
 7. A herbicidal composition comprising a herbicidally effective amount of a compound of formula I as defined in claim 5, wherein Y is phenyl, Z is methyl, and an agricultural adjuvant. 